Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Mark J, Evans"'
Autor:
Elaine M. Quinet, Michael D. Basso, Anita R. Halpern, David W. Yates, Robert J. Steffan, Valerie Clerin, Christine Resmini, James C. Keith, Thomas J. Berrodin, Irene Feingold, Wenyan Zhong, Helen B. Hartman, Mark J. Evans, Stephen J. Gardell, Elizabeth DiBlasio-Smith, William M. Mounts, Edward R. LaVallie, Jay Wrobel, Ponnal Nambi, George P. Vlasuk
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 12, Pp 2358-2370 (2009)
Liver X receptors (LXRs) are ligand-activated transcription factors that coordinate regulation of gene expression involved in several cellular functions but most notably cholesterol homeostasis encompassing cholesterol transport, catabolism, and abso
Externí odkaz:
https://doaj.org/article/ec0b71a6e2bf4790a3a5a3256e00f5d7
Autor:
Helen B. Hartman, Stephen J. Gardell, Chris J. Petucci, Shuguang Wang, Julie A. Krueger, Mark J. Evans
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 6, Pp 1090-1100 (2009)
The role of farnesoid X receptor (FXR) in the development of atherosclerosis has been unclear. Here, LDL receptor (LDLR−/−) or apolipoprotein E (apoE−/−) female or male mice were fed a Western diet and treated with a potent synthetic FXR agon
Externí odkaz:
https://doaj.org/article/25903fc888d44ef2b42266170edbcffd
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 2, Pp 193-203 (2009)
Multiple studies suggest increased conversion of cholesterol to bile acids by cholesterol 7α-hydroxylase (CYP7A1) protects against dyslipidemia and atherosclerosis. CYP7A1 expression is repressed by the sequential activity of two nuclear hormone rec
Externí odkaz:
https://doaj.org/article/475bde1e6e214a42a9451bcdcd691085
Autor:
Baihua Hu, Elaine Quinet, Irene Feingold, Igor Goljer, Thomas J. Berrodin, Mark J. Evans, James W Jetter, Jay Wrobel, Rayomand J. Unwalla, Michael D Basso, Annika Goos Nilsson, Anna Wilhelmsson
Publikováno v:
Journal of Medicinal Chemistry. 53:3296-3304
A series of phenyl sulfone substituted quinoxaline were prepared and the lead compound 13 (WYE-672) was shown to be a tissue selective LXR Agonist. Compound 13 demonstrated partial agonism for LXRbeta in kidney HEK-293 cells but did not activate Gal4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2418668e8e39d3a6194f3f8fbfab8dc3
https://doi.org/10.1021/jm100034x
https://doi.org/10.1021/jm100034x
Autor:
Baihua Hu, Rayomand J. Unwalla, Mark J. Evans, Jay E. Wrobel, Annika Goos-Nilsson, Anna Wilhelmsson, Michael D. Collini, Irene Feingold, Ron Bernotas, Ponnal Nambi, Elaine Quinet
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:689-693
A series of quinoline-3-carboxamide containing sulfones was prepared and found to have good binding affinity for LXRbeta and moderate binding selectivity over LXRalpha. The 8-Cl quinoline analog 33 with a high TPSA score, displayed 34-fold binding se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e8a4ec47fed1470799b19a5824da510
https://doi.org/10.1016/j.bmcl.2009.11.062
https://doi.org/10.1016/j.bmcl.2009.11.062
Autor:
Mark J. Evans, Stephen J. Gardell
Publikováno v:
Clinical Lipidology. 4:587-594
The farnesoid X receptor (FXR) is a nuclear hormone receptor that binds bile acids and regulates bile acid physiology. Bile acids are important in the regulation of plasma cholesterol levels both because bile acids are essential for absorption of cho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eca6aa99a50dd06dcb687452eccdd1f
https://doi.org/10.2217/clp.09.51
https://doi.org/10.2217/clp.09.51
Autor:
Mark J. Evans, Paige Erin Mahaney, Jay E. Wrobel, Matthew L. Crawley, Ray Unwalla, Kim Callain Younghee, John F. Mehlmann, Joseph T. Lundquist, Douglas C. Harnish
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5289-5292
Pyrrole[2,3-d]azepines have been identified as potent agonists of the farnesoid X receptor (FXR). Based on the planar X-ray crystal structure of WAY-362450 1 in the ligand binding domain and molecular modeling studies, non-planar reduced compounds we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87fc54b4c31896488fb9960b3d992553
https://doi.org/10.1016/j.bmcl.2009.07.148
https://doi.org/10.1016/j.bmcl.2009.07.148
Autor:
Stephen J. Gardell, Mark J. Evans, Chris Petucci, Shuguang Wang, Julie A. Krueger, Helen B. Hartman
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 6, Pp 1090-1100 (2009)
The role of farnesoid X receptor (FXR) in the development of atherosclerosis has been unclear. Here, LDL receptor (LDLR(-/-)) or apolipoprotein E (apoE(-/-)) female or male mice were fed a Western diet and treated with a potent synthetic FXR agonist,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a78eeed91ed4e5c856d4dbfc2c80d0f0
https://doi.org/10.1194/jlr.m800619-jlr200
https://doi.org/10.1194/jlr.m800619-jlr200
Autor:
Lisa Borges-Marcucci, Christine Huard, KehDih Lai, George P. Vlasuk, Douglas C. Harnish, Stephen J. Gardell, Mark J. Evans, Paige E. Mahaney, Julie A. Krueger, Shuguang Wang, Robert V. Martinez
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G543-G552
The nuclear hormone receptor farnesoid X receptor (FXR) plays a critical role in the regulation of bile acid, triglyceride (TG), and cholesterol homeostasis. WAY-362450 (FXR-450/XL335) is a potent synthetic FXR agonist as characterized in luciferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4b88e8a098fdd5710036af27194aeb
https://doi.org/10.1152/ajpgi.90585.2008
https://doi.org/10.1152/ajpgi.90585.2008
Publikováno v:
Occupational Ergonomics. 7:183-199
The most severe direct motion induced effect on the ability of an individual to work in a moving environment probably occurs in gross body tasks requiring balance and co-ordination, be it the crew trying to undertake their task effectively or the pas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::064cfe7163dfb5a8ddb9eb35ec13cbf8
https://doi.org/10.3233/oer-2007-7304
https://doi.org/10.3233/oer-2007-7304