Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Mark J, DiNubile"'
Autor:
Nicole Noren Hooten, Nicolle A. Mode, Edward Kowalik, Victor Omoniyi, Alan B. Zonderman, Ngozi Ezike, Mark J. DiNubile, Susan L. Levinson, Michele K. Evans
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-10 (2023)
Abstract Background The growing epidemic of the inflammation-related metabolic disease, type 2 diabetes mellitus, presents a challenge to improve our understanding of potential mechanisms or biomarkers to prevent or better control this age-associated
Externí odkaz:
https://doaj.org/article/adb485c651df4871839784531ae297ab
Autor:
Julie V. Catteeuw, Mark J. DiNubile
Publikováno v:
Clinical Infection in Practice, Vol 12, Iss , Pp 100088- (2021)
Life-threatening COVID-19 pneumonia follows an exaggerated immune response to SARS-CoV-2. pGSN levels fall after SARS-CoV-2 infection. Rhu-pGSN improves outcomes in models of inflammation. In an intubated patient with critical COVID-19 pneumonia and
Externí odkaz:
https://doaj.org/article/f361f34ded704185b8bfaf2dc9d061c7
Autor:
Michael S. Abers, Ottavia M. Delmonte, Emily E. Ricotta, Jonathan Fintzi, Danielle L. Fink, Adriana A. Almeida de Jesus, Kol A. Zarember, Sara Alehashemi, Vasileios Oikonomou, Jigar V. Desai, Scott W. Canna, Bita Shakoory, Kerry Dobbs, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Francesco Castelli, Camillo Rossi, Duilio Brugnoni, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angio’, Paolo Bonfanti, Riccardo Castagnoli, Daniela Montagna, Amelia Licari, Gian Luigi Marseglia, Emily F. Gliniewicz, Elana Shaw, Dana E. Kahle, Andre T. Rastegar, Michael Stack, Katherine Myint-Hpu, Susan L. Levinson, Mark J. DiNubile, Daniel W. Chertow, Peter D. Burbelo, Jeffrey I. Cohen, Katherine R. Calvo, John S. Tsang, NIAID COVID-19 Consortium, Helen C. Su, John I. Gallin, Douglas B. Kuhns, Raphaela Goldbach-Mansky, Michail S. Lionakis, Luigi D. Notarangelo
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19). However, the utility of specific immune-based biomarkers to predict clinical outc
Externí odkaz:
https://doaj.org/article/feaeec76ff49437f8d320c0de85e7c30
Autor:
Stephen R. Thom, Veena M. Bhopale, Awadhesh K. Arya, Deepa Ruhela, Abid R. Bhat, Nandita Mitra, Ole Hoffstad, D. Scot Malay, Ziad K. Mirza, John C. Lantis, Hadar A. Lev-Tov, Robert S. Kirsner, Ru-Ching Hsia, Susan L. Levinson, Mark J. DiNubile, David J. Margolis
Publikováno v:
ImmunoHorizons. 7:71-80
The proinflammatory state associated with diabetes mellitus (DM) remains poorly understood. We found patients with DM have 3- to 14-fold elevations of blood-borne microparticles (MPs) that bind phalloidin (Ph; Ph positive [+] MPs), indicating the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6569d4284337aad8a2a36564f6130aa
https://doi.org/10.4049/immunohorizons.2200099
https://doi.org/10.4049/immunohorizons.2200099
Autor:
Fleur P Paling, Karina Olsen, Kristin Ohneberg, Martin Wolkewitz, Vance G Fowler, Mark J DiNubile, Hasan S Jafri, Frangiscos Sifakis, Marc J M Bonten, Stephan J Harbarth, Jan A J W Kluytmans
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193445 (2018)
Identifying patients undergoing cardiothoracic surgery at high risk of Staphylococcus aureus surgical site infection (SSI) is a prerequisite for implementing effective preventive interventions. The objective of this study was to develop a risk predic
Externí odkaz:
https://doaj.org/article/c85c0c00de904f37a8bfbecb516dc0f6
Publikováno v:
Open forum infectious diseases. 9(8)
Background Excessive inflammation contributes to the morbidity and mortality of severe coronavirus disease 2019 (COVID-19) pneumonia. Recombinant human plasma gelsolin (rhu-pGSN) improves disease outcomes in diverse experimental models of infectious
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c96ed9d08161ea692cd702876064d1
https://pubmed.ncbi.nlm.nih.gov/35928505
https://pubmed.ncbi.nlm.nih.gov/35928505
Background Biomarkers are needed for frailty, a common phenotype often associated with muscle loss in older people. Plasma gelsolin (pGSN) is a protein largely synthesized and secreted by skeletal muscle. Aims To investigate whether pGSN could be a b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25efecd6402b13f54b2bf1a691d9582f
http://hdl.handle.net/10138/345171
http://hdl.handle.net/10138/345171
Autor:
Kol A. Zarember, John I. Gallin, Douglas B. Kuhns, Hanna S Hong, Harry L. Malech, Gal Wald, Robert J. Noveck, Emily F. Gliniewicz, John Audley, Thomas P. Stossel, Susan L Levinson, Mark J. DiNubile, Anthony F. Suffredini, Elizabeth M. Kang
Publikováno v:
Inflammation. 44:270-277
Plasma gelsolin (pGSN) is the secreted isoform of an intracellular actin remodeling protein found in high concentrations in human plasma. Clinical studies demonstrate reduced pGSN concentrations in several disease states, including severe trauma, bur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d314f2f8472e7f7296198651b7df2fe
https://doi.org/10.1007/s10753-020-01330-w
https://doi.org/10.1007/s10753-020-01330-w
Publikováno v:
Aging clinical and experimental research. 34(5)
Biomarkers are needed for frailty, a common phenotype often associated with muscle loss in older people. Plasma gelsolin (pGSN) is a protein largely synthesized and secreted by skeletal muscle.To investigate whether pGSN could be a biomarker of the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::408fbf81f6453418464206aaf7b792be
https://pubmed.ncbi.nlm.nih.gov/35169987
https://pubmed.ncbi.nlm.nih.gov/35169987
Autor:
Mark J. DiNubile, Quan Lu, Zhiping Yang, Susan L Levinson, Alice Bedugnis, Thomas P. Stossel, Lester Kobzik
Publikováno v:
J Infect Dis
Therapy to enhance host immune defenses may improve outcomes in serious infections, especially for antibiotic-resistant pathogens. Recombinant human plasma gelsolin (rhu-pGSN), a normally circulating protein, has beneficial effects in diverse preclin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5b360656c544283749053a4b4c17ae
https://doi.org/10.1093/infdis/jiz353
https://doi.org/10.1093/infdis/jiz353