Výsledky vyhledávání - "Mark J, Benvenga"

Akademický článek

Metabotropic Glutamate2 Receptors Play a Key Role in Modulating Head Twitches Induced by a Serotonergic Hallucinogen in Mice

Autor: Mark J. Benvenga, Stephen F. Chaney, Melvyn Baez, Thomas C. Britton, William J. Hornback, James A. Monn, Gerard J. Marek

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

There is substantial evidence that glutamate can modulate the effects of 5-hydroxytryptamine2A (5-HT2A) receptor activation through stimulation of metabotropic glutamate2/3 (mGlu2/3) receptors in the prefrontal cortex. Here we show that constitutive

Externí odkaz: https://doaj.org/article/9f965940a60d4dd5ac6205b068ebae96

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Akademický článek

LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy

Autor: Thomas Edward Fitch, Mark J Benvenga, Cynthia D Jesudason, Charity eZink, Amy B Vandergriff, Michelle eMenezes, Douglas A Schober, Linda M Rorick-Kehn

Publikováno v: Frontiers in Neuroscience, Vol 8 (2014)

We describe a novel, potent and selective orexin-2 (OX2)/hypocretin-2 receptor antagonist with in vivo activity in an animal model predictive of antidepressant-like efficacy. N-biphenyl-2-yl-4-fluoro-N-(1H-imidazol-2-ylmethyl)benzenesulfonamide HCl (

Externí odkaz: https://doaj.org/article/c842bba9e61d4eb8b6fd10b90297f0f5

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Metabotropic Glutamate

Autor: Mark J, Benvenga, Stephen F, Chaney, Melvyn, Baez, Thomas C, Britton, William J, Hornback, James A, Monn, Gerard J, Marek

Publikováno v: Frontiers in Pharmacology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6c0af9b23c7f0343c501750daec48ed5
https://pubmed.ncbi.nlm.nih.gov/29599719

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The 5-Hydroxytryptamine2A Receptor Antagonist R-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) Attenuates Impulsivity after Both Drug-Induced Disruption (Dizocilpine) and Enhancement (Antidepressant Drugs) of Differential-Reinforcement-of-Low-Rate 72-s Behavior in the Rat

Autor: Patrick L. Love, Paul A. Ardayfio, John T. Catlow, Mark J. Benvenga, Stephen F. Chaney, Steven P. Swanson, Gerard J. Marek

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 327:891-897

Previous work has suggested that N-methyl-d-aspartate (NMDA) receptor antagonism and 5-hydroxytryptamine (5-HT)(2A) receptor blockade may enhance and attenuate, respectively, certain types of impulsivity mediated by corticothalamostriatal circuits. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824e91454d9be3849159cd7a5ec0e700
https://doi.org/10.1124/jpet.108.143370

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SAR and biological evaluation of novel trans-3,4-dimethyl-4-arylpiperidine derivatives as opioid antagonists

Autor: Miles Goodman Siegel, Peggy L. Surface, Nuria Diaz, Jamie H. McKinzie, Ryan Favors, Mark J. Benvenga, Joseph M. Woodland, Michael A. Statnick, Nita J. Patel, Elizabeth Marie Thomas, Paul J. Emmerson, Steven C. Peters, Michael Mangold, Charles H. Mitch, Harlan E. Shannon, Steven James Quimby

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:3844-3848

The phenolic hydroxy group of opiate-derived ligands is of known importance for biological activity. We have developed a SAR study around LY255582 by comparing the effect of the hydroxy group in the 2- and 4-position of the phenyl ring. Also, we have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ea787b47f788df64ec21427693cc2e
https://doi.org/10.1016/j.bmcl.2005.05.123

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LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy

Autor: Charity Zink, Cynthia Darshini Jesudason, Thomas E. Fitch, Mark J. Benvenga, Michelle M Menezes, Amy B Vandergriff, Linda M. Rorick-Kehn, Douglas A. Schober

Publikováno v: Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 8 (2014)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69fd8fda8bf3ab96960feb75c8f41bd5
http://europepmc.org/articles/PMC3904085

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Disinhibitory effects of LY354740, a new mGluR2 agonist, on behaviors suppressed by electric shock in rats and pigeons

Autor: J. David Leander, Mark J. Benvenga, James A. Monn, Carl D Overshiner

Publikováno v: Drug Development Research. 47:37-44

Compounds which affect glutamate transmission are reported as anxiolytic in a number of animal models. In the present studies, we evaluated the anxiolytic effect of a new mGluR2 agonist, LY354740, in rats and pigeons. LY354740 was evaluated in three

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22eba5c8c4da595a5a1a875284942c31
https://doi.org/10.1002/(sici)1098-2299(199905)47:1<37::aid-ddr5>3.0.co

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Pharmacological profile of LY301317, a potent and selective 5-HT1A agonist

Autor: David O. Calligaro, David L. Nelson, Susan K. Hemrick-Luecke, Mary C. Wolff, James B. Lucot, Jaswant Singh Gidda, Mark J. Benvenga, Carl D Overshiner, Ray W. Fuller, J. David Leander

Publikováno v: Drug Development Research. 40:17-34

LY301317 ((4r)-(-)-4-(dipropylamino)-6-(5-oxazolinyl)-1,3,4,5-tetrahydrobenz[c,d]indole) has high affinity for the 5-HT 1A receptor and weak affinity for the 5-HT 1D and histamine-H 1 receptors. No significant affinity was found for the other amine r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0bb0ec346877982d25b12a9dca01e52
https://doi.org/10.1002/(sici)1098-2299(199701)40:1<17::aid-ddr2>3.0.co

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