Výsledky vyhledávání - "Mark I. Furman"

Whole Blood Analysis of Leukocyte-Platelet Aggregates

Autor: Alan D. Michelson, Andrew L. Frelinger, Mark I. Furman, Marc R. Barnard, Lori A. Krueger

Publikováno v: Current Protocols in Cytometry

In inflammatory and thrombotic syndromes, platelets aggregate with circulating leukocytes, especially monocytes and neutrophils. This leukocyte-platelet aggregate formation is initiated primarily through platelet surface expression of P-selectin (CD6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e72b733a6cc0711fee4cf68fb486ecc
https://doi.org/10.1002/cpcy.8

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The Influence of Intermittent Hypoxemia on Platelet Activation in Obese Patients with Obstructive Sleep Apnea

Autor: Mark I. Furman, Alan D. Michelson, Marc R. Barnard, Shilpa Rahangdale, Victor Novack, Atul Malhotra, Andrew L. Frelinger, KE Stevenson, Susie Yim Yeh

Publikováno v: Journal of Clinical Sleep Medicine. :172-178

Objectives:Literature regarding platelet function in obstructive sleep apnea (OSA) has considerable limitations. Given the central role of platelets in atherothrombosis and the known cardiovascular...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7910f4e73ec6ba0ef6cce282d3cbcf04
https://doi.org/10.5664/jcsm.28105

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Heparin-associated anti-Xa activity and platelet-derived prothrombotic and proinflammatory biomarkers in moderate to high-risk patients with acute coronary syndrome

Autor: Hongqiu Yang, Mark I. Furman, Craig J. Reist, Kenneth W. Mahaffey, Richard C. Becker, Neal S. Kleiman, John L. Petersen, A. Michael Lincoff, Ali J. Marian, Stanley L. Hazen

Publikováno v: Journal of Thrombosis and Thrombolysis. 31:146-153

Heparin compounds, to include fractionated and unfractionated preparations, exert both antithrombotic and antiinflammatory effects through combined inhibition of factor Xa and thrombin. The contribution of modulated platelet activity in vivo is less

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91095f774f54df46475dc45e21a1f175
https://doi.org/10.1007/s11239-010-0532-y

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Association of Cyclooxygenase-1-Dependent and -Independent Platelet Function Assays With Adverse Clinical Outcomes in Aspirin-Treated Patients Presenting for Cardiac Catheterization

Autor: Andrew L. Frelinger, YouFu Li, Marc R. Barnard, Marsha L. Fox, Mark I. Furman, Douglas J. Christie, Matthew D. Linden, Alan D. Michelson

Publikováno v: Circulation. 120:2586-2596

Background— Poor clinical outcome in aspirin-treated patients has been termed aspirin resistance and may result from inadequate inhibition of platelet cyclooxygenase-1 (COX-1) by aspirin. The objectives of this study were to determine prospectively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683dd041a7f1299038560959abb9439f
https://doi.org/10.1161/circulationaha.109.900589

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Mortality following placement of drug-eluting and bare-metal stents for ST-segment elevation acute myocardial infarction in the Global Registry of Acute Coronary Events

Autor: Alvaro Avezum, Frans Van de Werf, Keith A.A. Fox, Kim A. Eagle, Joel M. Gore, Phillippe Gabriel Steg, Shaun G. Goodman, Mark I. Furman, Gilles Montalescot, Wei Huang

Publikováno v: European Heart Journal. 30:321-329

Aims To assess mortality after drug-eluting stent (DES) or bare-metal stent (BMS) for ST-segment elevation myocardial infarction (STEMI). Methods and results In this multinational registry, 5093 STEMI patients received a stent: 1313 (26%) a DES and 3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17c14326af8b2899ad0184f460499aa
https://doi.org/10.1093/eurheartj/ehn604

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The active metabolite of prasugrel inhibits adenosine diphosphate- and collagen-stimulated platelet procoagulant activities

Autor: YouFu Li, Marc R. Barnard, Joseph A. Jakubowski, Inge Tarnow, Alan D. Michelson, Mark I. Furman, Marsha L. Fox, Matthew D. Linden, Kenneth J. Winters, Atsuhiro Sugidachi, Andrew L. Frelinger

Publikováno v: Journal of Thrombosis and Haemostasis. 6:359-365

Summary. Background: Prasugrel is a novel antiplatelet prodrug of the same thienopyridine class as clopidogrel and ticlopidine. Metabolism of prasugrel generates the active metabolite R-138727, an antagonist of the platelet P2Y12 adenosine diphosphat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed30d29752db995e147e7a1ebe2c24a9
https://doi.org/10.1111/j.1538-7836.2007.02838.x

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Investigating the Mechanisms of Hyporesponse to Antiplatelet Approaches

Autor: Christopher P. Cannon, Stephen D. Wiviott, Mark I. Furman, Eric R. Bates, Paul A. Gurbel, Deepak L. Bhatt, Peter B. Berger, Dominick J. Angiolillo, Eric D. Peterson, Eugene Braunwald, Alan D. Michelson

Publikováno v: Clinical Cardiology. 31:I21-I27

Hyporesponsiveness, or resistance, to antiplatelet therapy may be a major contributor to poorer outcomes among cardiac patients and may be attributed to an array of mechanisms—both modifiable and unmodifiable. Recent evidence has uncovered clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6eb46ed93e95478755e9e4d75a6b87a
https://doi.org/10.1002/clc.20360

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’Postconditioning’ the human heart: Multiple balloon inflations during primary angioplasty may confer cardioprotection

Autor: Craig S. Smith, Karin Przyklenk, Chad E. Darling, Patrick B. Solari, Mark I. Furman

Publikováno v: Basic Research in Cardiology. 102:274-278

Growing evidence from experimental models suggests that relief of myocardial ischemia in a stuttering manner (i.e., 'postconditioning' [PostC] with brief cycles of reperfusion-reocclusion) limits infarct size. However, the potential clinical efficacy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76cad4dbb37e7f6a558832e18c49663
https://doi.org/10.1007/s00395-007-0643-6

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