Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Mark Hochstrasser"'
Autor:
Gabriel Ruiz-Romero, María Dolores Berdún, Mark Hochstrasser, Silvia Salas-Pino, Rafael R. Daga
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111095- (2024)
Summary: In addition to the degradation of cell-cycle proteins, short-lived, damaged, or unfolded proteins are constantly cleared from cells by the proteasome. During proliferation, the proteasome localizes to the nucleus and cytoplasm; however, the
Externí odkaz:
https://doaj.org/article/bb7d26f9b8074939a6a339c47b330b6a
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract In eukaryotes, the ubiquitin–proteasome system is an essential pathway for protein degradation and cellular homeostasis. 26S proteasomes concentrate in the nucleus of budding yeast Saccharomyces cerevisiae due to the essential import adapt
Externí odkaz:
https://doaj.org/article/ced8a9f864954f5894d1fa701d04b1ee
Autor:
Tolga T. Ölmez, David F. Moreno, Ping Liu, Zane M. Johnson, Madeline M. McGinnis, Benjamin P. Tu, Mark Hochstrasser, Murat Acar
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Application of microfluidic platforms facilitated high-precision measurements of yeast replicative lifespan (RLS); however, comparative quantification of lifespan across strain libraries has been missing. Here we microfluidically measure the
Externí odkaz:
https://doaj.org/article/a62e18541d164310a8f2f49075b01fb6
Autor:
Haofeng Wang, Yunjie Xiao, Xia Chen, Mengwen Zhang, Guangxin Sun, Feng Wang, Lin Wang, Hanxiao Zhang, Xiaoyu Zhang, Xin Yang, Wenling Li, Yi Wei, Deqiang Yao, Bing Zhang, Jun Li, Wen Cui, Fenghua Wang, Cheng Chen, Wei Shen, Dan Su, Fang Bai, Jinhai Huang, Sheng Ye, Lei Zhang, Xiaoyun Ji, Wei Wang, Zefang Wang, Mark Hochstrasser, Haitao Yang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Wolbachia induced cytoplasmic incompatibility (CI) is caused by linked pairs of genes named cifA and cifB. Here, authors show that the residues at interfaces of the CidA-CidB complex is crucial for their binding and contribute to the diversity of CI.
Externí odkaz:
https://doaj.org/article/5351223854f14543a1a92277551c3456
Elements of the ERAD ubiquitin ligase Doa10 regulating sequential poly-ubiquitylation of its targets
Autor:
Adrian B. Mehrtash, Mark Hochstrasser
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105351- (2022)
Summary: In ER-associated degradation (ERAD), misfolded ER proteins are degraded by the proteasome after undergoing ubiquitylation. Yeast Doa10 (human MARCHF6/TEB4) is a membrane-embedded E3 ubiquitin ligase that functions with E2s Ubc6 and Ubc7. Ubc
Externí odkaz:
https://doaj.org/article/e27971feecf64196b012d15ce2889e35
Publikováno v:
PLoS Biology, Vol 20, Iss 6, p e3001501 (2022)
Protein ubiquitylation is an important posttranslational modification affecting a wide range of cellular processes. Due to the low abundance of ubiquitylated species in biological samples, considerable effort has been spent on methods to purify and d
Externí odkaz:
https://doaj.org/article/4d747f9c9c3347bbbb87cd87a87d79c8
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 6, Pp 931-939 (2020)
Stress response: how cells wrestle with SUMO disruption Cellular stress caused by disrupting attachment of the ubiquitous small ubiquitin-like modifier (SUMO) proteins, which are present in most organisms and regulate numerous DNA processes and stres
Externí odkaz:
https://doaj.org/article/e284bab50fa64d9ab5b52117e9c0a65e
Autor:
Jason M. Berk, Christopher Lim, Judith A. Ronau, Apala Chaudhuri, Hongli Chen, John F. Beckmann, J. Patrick Loria, Yong Xiong, Mark Hochstrasser
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Many pathogens manipulate ubiquitin-mediated signaling to evade host cell defense. Here, the authors characterize the structure and enzymatic activity of a deubiquitylase domain from the causative pathogen of scrub typhus, providing evidence for a di
Externí odkaz:
https://doaj.org/article/e72272f032014c63830d698e467f3709
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Wolbachia is an obligate intracellular bacterium that can alter reproduction of its arthropod hosts, often through a mechanism called cytoplasmic incompatibility (CI). In CI, uninfected females fertilized by infected males yield few offsprin
Externí odkaz:
https://doaj.org/article/f63de31552244b41918ce379d85f1128
Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease
Autor:
Hong-Yeoul Ryu, Francesc López-Giráldez, James Knight, Soo Seok Hwang, Christina Renner, Stefan G. Kreft, Mark Hochstrasser
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Transient aneuploidy enables cells to survive sudden environmental changes before longterm cellular adaptations are established. Here, the authors show that yeast cells respond to the acute loss of Ulp2 SUMO protease by rapid induction of aneuploidy,
Externí odkaz:
https://doaj.org/article/fa07ec2c498048edae01417a7f9d5564