Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Mark Hibberd"'
1
The Effect of Food on the Pharmacokinetics of the Potassium-Competitive Acid Blocker Vonoprazan
Autor: Eckhard Leifke, Mark Hibberd, Colin W. Howden, Darcy J. Mulford
Publikováno v: Clinical pharmacology in drug development. 11(2)
Herein, we report a food-effect study of vonoprazan, an oral potassium-competitive acid blocker. In a phase 1, randomized, open-label, crossover study, healthy subjects received a single 20-mg dose of vonoprazan either following an overnight fast or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e8c573ac0e8d224184d7628244e896
https://pubmed.ncbi.nlm.nih.gov/34431240
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2
Population pharmacokinetic–pharmacodynamic modelling of the relationship between testosterone and prostate specific antigen in patients with prostate cancer during treatment with leuprorelin
Autor: Nelleke Snelder, Nolan Wood, Kirsten R. Bergmann, Henk-Jan Drenth, Graham Scott, Mark Hibberd
Publikováno v: Br J Clin Pharmacol
Aims This investigation aimed to quantitatively characterize the relationship between the gonadotropin-releasing hormone agonist leuprorelin, testosterone (T) and prostate specific antigen (PSA) concentrations over time, to aid identification of a ta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c795721c4c4a1fdf73b252f4ff38661a
https://europepmc.org/articles/PMC6533438/
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4
Randomised clinical trial: safety, tolerability, pharmacokinetics and pharmacodynamics of repeated doses of TAK-438 (vonoprazan), a novel potassium-competitive acid blocker, in healthy male subjects
Autor: K. Ashida, Mark Hibberd, Jenkins Richard, Yuuichi Sakurai, Akira Nishimura, Tomoki Yoneyama, S. Warrington, Helen Jenkins, Hiroyuki Okamoto, Y. Ogama
Publikováno v: Alimentary Pharmacology & Therapeutics
Background TAK-438 (vonoprazan) is a potassium-competitive acid blocker that reversibly inhibits gastric H+, K+-ATPase. Aim To evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of TAK-438 in healthy Japanese and non-Japanese me
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5efcd0ff1aa4c07516c0e0541c5bfdd
https://doi.org/10.1111/apt.13121
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5
Atmospheric mercury emissions in Australia from anthropogenic, natural and recycled sources
Autor: Anthony Morrison, Sunhee Lee, Peter F. Nelson, Hugh Malfroy, Martin Cope, Mark Hibberd, John L. McGregor, C. P. Meyer
Publikováno v: Atmospheric Environment. 62:291-302
The United Nations Environment Programme (UNEP) has begun a process of developing a legally binding instrument to manage emissions of mercury from anthropogenic sources. The UNEP Governing Council has concluded that there is sufficient evidence of si
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5dd25a1b789d7cba5398b2520080d3b
https://doi.org/10.1016/j.atmosenv.2012.07.067
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8
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Rising TAK-438 (Vonoprazan) Doses in Healthy Male Japanese/non-Japanese Subjects
Autor: Hiroyuki Okamoto, Jenkins Richard, Helen Jenkins, Tomoki Yoneyama, Jorg Taubel, Mark Hibberd, Akira Nishimura, Kiyoshi Ashida, Shin Irie, Yuuichi Sakurai, Gale Kennedy
Publikováno v: Clinical and Translational Gastroenterology
OBJECTIVES: To evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of TAK-438 (vonoprazan, a potassium-competitive acid blocker) in healthy male subjects. METHODS: In two phase I, randomized, double-blind, placebo-controlled, single
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59d32879b32eca866f9731caa6a0a4e
https://doi.org/10.1038/ctg.2015.18
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