Host response to influenza infections in human blood: association of influenza severity with host genetics and transcriptomic response

Autor: Klaus Schughart, Amber M. Smith, Ephraim L. Tsalik, Stephen C. Threlkeld, Subhashini Sellers, William A. Fischer, Jens Schreiber, Eva Lücke, Markus Cornberg, Jennifer Debarry, Christopher W. Woods, Micah T. McClain, Mark Heise

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionInfluenza virus infections are a major global health problem. Influenza can result in mild/moderate disease or progress to more severe disease, leading to high morbidity and mortality. Severity is thought to be primarily driven by immunop

Externí odkaz: https://doaj.org/article/da5c678977964239adaadc4fd7821957

Virology under the Microscope—a Call for Rational Discourse

Autor: Felicia Goodrum, Anice C. Lowen, Seema Lakdawala, James Alwine, Arturo Casadevall, Michael J. Imperiale, Walter Atwood, Daphne Avgousti, Joel Baines, Bruce Banfield, Lawrence Banks, Sumita Bhaduri-McIntosh, Deepta Bhattacharya, Daniel Blanco-Melo, David Bloom, Adrianus Boon, Steeve Boulant, Curtis Brandt, Andrew Broadbent, Christopher Brooke, Craig Cameron, Samuel Campos, Patrizia Caposio, Gary Chan, Anna Cliffe, John Coffin, Kathleen Collins, Blossom Damania, Matthew Daugherty, Kari Debbink, James DeCaprio, Terence Dermody, Jimmy Dikeakos, Daniel DiMaio, Rhoel Dinglasan, W. Paul Duprex, Rebecca Dutch, Nels Elde, Michael Emerman, Lynn Enquist, Bentley Fane, Ana Fernandez-Sesma, Michelle Flenniken, Lori Frappier, Matthew Frieman, Klaus Frueh, Michaela Gack, Marta Gaglia, Tom Gallagher, Denise Galloway, Adolfo García-Sastre, Adam Geballe, Britt Glaunsinger, Stephen Goff, Alexander Greninger, Meaghan Hancock, Eva Harris, Nicholas Heaton, Mark Heise, Ekaterina Heldwein, Brenda Hogue, Stacy Horner, Edward Hutchinson, Joseph Hyser, William Jackson, Robert Kalejta, Jeremy Kamil, Stephanie Karst, Frank Kirchhoff, David Knipe, Timothy Kowalik, Michael Lagunoff, Laimonis Laimins, Ryan Langlois, Adam Lauring, Benhur Lee, David Leib, Shan-Lu Liu, Richard Longnecker, Carolina Lopez, Micah Luftig, Jennifer Lund, Balaji Manicassamy, Grant McFadden, Michael McIntosh, Andrew Mehle, W. Allen Miller, Ian Mohr, Cary Moody, Nathaniel Moorman, Anne Moscona, Bryan Mounce, Joshua Munger, Karl Münger, Eain Murphy, Mojgan Naghavi, Jay Nelson, Christopher Neufeldt, Janko Nikolich, Christine O'Connor, Akira Ono, Walter Orenstein, David Ornelles, Jing-hsiung Ou, John Parker, Colin Parrish, Andrew Pekosz, Philip Pellett, Julie Pfeiffer, Richard Plemper, Stephen Polyak, John Purdy, Dohun Pyeon, Miguel Quinones-Mateu, Rolf Renne, Charles Rice, John Schoggins, Richard Roller, Charles Russell, Rozanne Sandri-Goldin, Martin Sapp, Luis Schang, Scott Schmid, Stacey Schultz-Cherry, Bert Semler, Thomas Shenk, Guido Silvestri, Viviana Simon, Gregory Smith, Jason Smith, Katherine Spindler, Megan Stanifer, Kanta Subbarao, Wesley Sundquist, Mehul Suthar, Troy Sutton, Andrew Tai, Vera Tarakanova, Benjamin tenOever, Scott Tibbetts, Stephen Tompkins, Zsolt Toth, Koenraad van Doorslaer, Marco Vignuzzi, Nicholas Wallace, Derek Walsh, Michael Weekes, Jason Weinberg, Matthew Weitzman, Sandra Weller, Sean Whelan, Elizabeth White, Bryan Williams, Christiane Wobus, Scott Wong, Andrew Yurochko

Publikováno v: mSphere, Vol 8, Iss 2 (2023)

ABSTRACT Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines an

Externí odkaz: https://doaj.org/article/88d633fd96714f98a0ed8b9526e9581b

CSL112 (Apolipoprotein A-I [Human]) Strongly Enhances Plasma Apoa-I and Cholesterol Efflux Capacity in Post-Acute Myocardial Infarction Patients: A PK/PD Substudy of the AEGIS-I Trial

Autor: C. Michael Gibson MS, MD, Syed Hassan A. Kazmi MD, Serge Korjian MD, Gerald Chi MD, Adam T. Phillips MD, Sahar Memar Montazerin MD, Danielle Duffy MD, Bo Zheng PhD, Mark Heise PhD, Charles Liss MS, Lawrence I. Deckelbaum MD, Samuel D. Wright PhD, Andreas Gille MD, PhD

Publikováno v: Journal of Cardiovascular Pharmacology and Therapeutics, Vol 27 (2022)

Introduction: Cholesterol efflux capacity (CEC) is impaired following acute myocardial infarction (AMI). CSL112 is an intravenous preparation of human plasma-derived apoA-I formulated with phosphatidylcholine (PC). CSL112 is intended to improve CEC a

Externí odkaz: https://doaj.org/article/43aa47289dd347168bc134341711e1bc

Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection.

Autor: Qibin Geng, Wanbo Tai, Victoria K Baxter, Juan Shi, Yushun Wan, Xiujuan Zhang, Stephanie A Montgomery, Sharon A Taft-Benz, Elizabeth J Anderson, Audrey C Knight, Kenneth H Dinnon, Sarah R Leist, Ralph S Baric, Jian Shang, Sung-Wook Hong, Aleksandra Drelich, Chien-Te K Tseng, Marc Jenkins, Mark Heise, Lanying Du, Fang Li

Publikováno v: PLoS Pathogens, Vol 17, Iss 9, p e1009897 (2021)

The key to battling the COVID-19 pandemic and its potential aftermath is to develop a variety of vaccines that are efficacious and safe, elicit lasting immunity, and cover a range of SARS-CoV-2 variants. Recombinant viral receptor-binding domains (RB

Externí odkaz: https://doaj.org/article/b352f3bd2b6c4435b8d94622e85b8927

478 Translation of a therapeutic neoantigen vaccine workflow to SARS-CoV-2 vaccine development

Autor: Benjamin Vincent, Timothy O’Donnell, Maria Sambade, Julia Kodysh, Steven Vensko, Wolfgang Beck, Christof Smith, Sarah Entwistle, Caryn Willis, Jason Garness, Eric Routh, Kelly Olsen, Brandon Carpenter, Kaylee Gentry, Maria Fadri, Misha Fini, Amber Washington, Carsten Haber, Kirsten Heiss, Volker Stadler, Erik Garrison, Oliver Grant, Robert Woods, Mark Heise, Alexander Rubinsteyn

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Externí odkaz: https://doaj.org/article/9975b5795bbd45349adb1107b50c0243