Renewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies

Autor: Siddharthan Chandran, Mark Head, Alison Green, Richard Knight, Diane Ritchie, Paul A. De Sousa

Publikováno v: De Sousa, P A, Ritchie, D, Green, A, Chandran, S, Knight, R & Head, M W 2018, ' Renewed assessment of the risk of emergent advanced cell therapies to transmit neuroproteinopathies ', Acta Neuropathologica . https://doi.org/10.1007/s00401-018-1941-9
Acta Neuropathologica

The inadvertent transmission of long incubating, untreatable and fatal neurodegenerative prionopathies, notably iatrogenic Creutzfeldt–Jakob disease, following transplantation of cadaver-derived corneas, pituitary growth, hormones and dura mater, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec42998eb64d15c4d697aee2c6c76640
https://www.pure.ed.ac.uk/ws/files/77432124/Sousa2018_Article_RenewedAssessmentOfTheRiskOfEm.pdf

Rapid amplification of prions from variant Creutzfeldt-Jakob disease cerebrospinal fluid:Detection of vCJD prions in human CSF samples

Autor: Alison Green, Marcelo A. Barria, Richard Knight, Andrew J Lee, Mark Head

Publikováno v: Barria, M A, Lee, A J, Green, A J, Knight, R & Head, M W 2018, ' Rapid amplification of prions from variant Creutzfeldt-Jakob disease cerebrospinal fluid : Detection of vCJD prions in human CSF samples ', Journal of Pathology: Clinical Research . https://doi.org/10.1002/cjp2.90

Human prion diseases constitute a group of infectious and invariably fatal neurodegenerative disorders associated with misfolding of the prion protein. Variant Creutzfeldt-Jakob disease (vCJD) is a zoonotic prion disease linked to oral exposure to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6c217d9cf1fbd1dc9c8cfd8f6d77dc
https://www.pure.ed.ac.uk/ws/files/53400141/Barria_et_al_2018_The_Journal_of_Pathology_Clinical_Research.pdf

Amyloid-β accumulation in the CNS in human growth hormone recipients in the UK

Autor: Patrick F. Chinnery, James W. Ironside, Margaret Le Grice, Wei Wei, Suzanne Lowrie, Michael J. Keogh, Helen Yull, Diane Ritchie, Peter Adlard, Rosemary J. Jackson, Kimberley Burns, Alexander Peden, Mark Head

Publikováno v: Acta Neuropathologica
Ritchie, D L, Adlard, P, Peden, A H, Lowrie, S, Le Grice, M, Burns, K, Jackson, R J, Yull, H, Keogh, M J, Wei, W, Chinnery, P F, Head, M W & Ironside, J W 2017, ' Amyloid-β accumulation in the CNS in human growth hormone recipients in the UK ', Acta Neuropathologica, vol. 134, no. 2, pp. 221–240 . https://doi.org/10.1007/s00401-017-1703-0

Human-to-human transmission of Creutzfeldt–Jakob disease (CJD) has occurred through medical procedures resulting in iatrogenic CJD (iCJD). One of the commonest causes of iCJD was the use of human pituitary-derived growth hormone (hGH) to treat prim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bae69a1fe3919d7bc8d1d125c5ef5d0
https://pubmed.ncbi.nlm.nih.gov/28349199

Variant CJD

Autor: Aileen Boyle, Mark Head, Sandra McCutcheon, James W. Ironside, Robert G. Will, Jean Manson, Richard Knight, Abigail B. Diack

Publikováno v: Diack, A B, Head, M W, McCutcheon, S, Boyle, A, Knight, R, Ironside, J W, Manson, J C & Will, R G 2014, ' Variant CJD : 18 years of research and surveillance ', Prion, vol. 8, no. 4, pp. 286-295 . https://doi.org/10.4161/pri.29237

It is now 18 years since the first identification of a case of vCJD in the UK. Since that time there has been much speculation over how vCJD might impact on human health. To date there have been 177 cases reports in the UK and a further 51 cases worl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de0b8e3ac85a6d6f9c3cec3b82b779e
https://doi.org/10.4161/pri.29237

Human Tonsil-Derived Follicular Dendritic-Like Cells are Refractory to Human Prion Infection in Vitro and Traffic Disease-Associated Prion Protein to Lysosomes

Autor: James W. Ironside, Mark Head, Zuzana Krejciova, Jean Manson, Paul A. De Sousa

Publikováno v: Krejciova, Z, De Sousa, P, Manson, J, Ironside, J W & Head, M W 2014, ' Human Tonsil-Derived Follicular Dendritic-Like Cells are Refractory to Human Prion Infection in Vitro and Traffic Disease-Associated Prion Protein to Lysosomes ', American Journal of Pathology, vol. 184, no. 1, pp. 64-70 . https://doi.org/10.1016/j.ajpath.2013.09.013

The molecular mechanisms involved in human cellular susceptibility to prion infection remain poorly defined. This is due, in part, to the absence of any well characterized and relevant cultured human cells susceptible to infection with human prions,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532f53550e9e046587ea458f9a393854
https://doi.org/10.1016/j.ajpath.2013.09.013