Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Mark H. Whitnall"'
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 14119-14135 (2013)
There is a paucity of large animal models to study both the extent and the health risk of ionizing radiation exposure in humans. One promising candidate for such a model is the minipig. Here, we evaluate the minipig for its potential in γ-H2AX-based
Externí odkaz:
https://doaj.org/article/c19b604707bc409baeeefa913f60202d
Autor:
Xiang Hong Li, Dadin Fu, Nabil H. Latif, Conor P. Mullaney, Patrick H. Ney, Steven R. Mog, Mark H. Whitnall, Venkataraman Srinivasan, Mang Xiao
Publikováno v:
Haematologica, Vol 95, Iss 12 (2010)
Background Exposure to γ-radiation causes rapid hematopoietic cell apoptosis and bone marrow suppression. However, there are no approved radiation countermeasures for the acute radiation syndrome. In this study, we demonstrated that natural δ-tocot
Externí odkaz:
https://doaj.org/article/f0e1f024b1ef4a1ea5fc54dddeb6a8e5
Autor:
Maria Moroni, Eric Lombardini, Rudolph Salber, Mehdi Kazemzedeh, Vitaly Nagy, Cara Olsen, Mark H Whitnall
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25210 (2011)
The animal efficacy rule addressing development of drugs for selected disease categories has pointed out the need to develop alternative large animal models. Based on this rule, the pathophysiology of the disease in the animal model must be well char
Externí odkaz:
https://doaj.org/article/062755110b794fc3b8b9700075484094
Autor:
Graça Almeida-Porada, Arthur Gross, Mark H. Whitnall, Daniel Noutai, Opeyemi Fadiyimu, Rudolph E. Salber, Lynnette H. Cary, Yared Kidane
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1795 (2019)
Volume 20
Issue 7
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1795 (2019)
Volume 20
Issue 7
The bone marrow (BM) microenvironment plays a crucial role in the maintenance and regeneration of hematopoietic stem (HSC) and progenitor cells (HSPC). In particular, the vascular niche is responsible for regulating HSC maintenance, differentiation,
Autor:
Lynnette H. Cary, Mark H. Whitnall, Daniel Noutai, Barbara F. Ngudiankama, Margaret S. Williams, Rudolph E. Salber
Publikováno v:
Radiation Research. 181:592-604
Detonation of an improvised nuclear device near a population center would cause significant casualties from the acute radiation syndrome (ARS) due to exposure to mixed neutron/gamma fields (MF). The pathophysiology of ARS involves inflammation, micro
Autor:
Dadin Fu, Mang Xiao, Thomas B. Elliott, Vilmar Villa, Cam T. Ha, Mark H. Whitnall, Michael R. Landauer, Sanchita P. Ghosh, Xiang Hong Li, David L. Bolduc
Publikováno v:
Radiation Research. 180:649-657
We recently demonstrated that natural delta-tocotrienol (DT3) significantly enhanced survival in total-body irradiated (TBI) mice, and protected mouse bone marrow cells from radiation-induced damage through Erk activation-associated mTOR survival pat
Autor:
Cara H. Olsen, Christine Christensen, Mark H. Whitnall, Rebecca K. Holt, Barbara F. Ngudiankama, Rossitsa Owens, Eric D. Lombardini, Maria Moroni
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 86:986-992
Purpose We are characterizing the Gottingen minipig as an additional large animal model for advanced drug testing for the acute radiation syndrome (ARS) to enhance the discovery and development of novel radiation countermeasures. Among the advantages
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 14119-14135 (2013)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 14; Issue 7; Pages: 14119-14135
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 14; Issue 7; Pages: 14119-14135
There is a paucity of large animal models to study both the extent and the health risk of ionizing radiation exposure in humans. One promising candidate for such a model is the minipig. Here, we evaluate the minipig for its potential in γ-H2AX-based
Autor:
Tzu-Cheg Kao, Juong G. Rhee, Mark H. Whitnall, Marcy B. Grace, William E. Jackson, Vijay K. Singh
Publikováno v:
Journal of Radiation Research
The steroid androst-5-ene-3ß,17ß-diol (5-androstenediol, 5-AED) elevates circulating granulocytes and platelets in animals and humans, and enhances survival during the acute radiation syndrome (ARS) in mice and non-human primates. 5-AED promotes su
Publikováno v:
Cytokine. 58:406-414
The purpose of this study was to further elucidate the radioprotective role of granulocyte colony-stimulating factor (G-CSF) induced in response to irradiation. The induction of G-CSF and interleukin-6 (IL-6) in response to radiation exposure was eva