Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Mark H. Watson"'
Autor:
William Z. Potter, Alzheimer’s Disease Neuroimaging Initiative, Laetitia Cortes, Mark H. Watson, Daniel Chelsky, Susan Baker, Nandini Raghavan, Daniel S. Spellman, Kelly L. Umaña, Clifford R. Jack, Ondrej Libiger, Rosa M. Canet‐Avilés, Michael C. Biarnes, Yannick-André Breton, Leslie M. Shaw, Angus C. Nairn
Publikováno v:
Alzheimers Dement
Introduction Biomarkers that reflect pathologic processes affecting neuronal function during preclinical and early stages of Alzheimer's disease (AD) are needed to aid drug development. Methods A targeted, stable isotope, quantitative mass spectromet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11592cef2afb777517e0bc5355fbea6
https://europepmc.org/articles/PMC9222372/
https://europepmc.org/articles/PMC9222372/
Autor:
Leslie M. Shaw, Rosa M. Canet‐Avilés, Daniel Chelsky, Angus C. Nairn, Clifford R. Jack, Daniel S Spellman, Nandini Raghavan, Yannick-André Breton, William Z. Potter, Laetitia Cortes, Ondrej Libiger, Mark H. Watson, Susan Baker, Kelly L. Umaña
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5de6d6a2bde87bfed51678be2bcb2d7f
https://doi.org/10.1002/alz.047605
https://doi.org/10.1002/alz.047605
Autor:
Bonnie L. Bertolaet, Gilles Divita, Meira Wolff, Steven I. Reed, Mark H. Watson, Martha Henze, Duncan J. Clarke
Publikováno v:
Nature Structural Biology. 8:417-422
Rad23 is a highly conserved protein involved in nucleotide excision repair (NER) that associates with the proteasome via its N-terminus. Its C-terminal ubiquitin-associated (UBA) domain is evolutionarily conserved from yeast to humans. However, the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::034466d317c78ec504f30e03d2d9b050
https://doi.org/10.1038/87575
https://doi.org/10.1038/87575
Autor:
Wilhelm Krek, Heimo Strohmaier, Adrian L. Smith, Steven I. Reed, Aimee K. Ryan, Charles Spruck, Mark H. Watson
Publikováno v:
Molecular Cell. 7:639-650
The Cks/Suc1 proteins associate with CDK/cyclin complexes, but their precise function(s) is not well defined. Here we demonstrate that Cks1 directs the ubiquitin-mediated proteolysis of the CDK-bound substrate p27Kip1 by the protein ubiquitin ligase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1bba6fd7c322405f4698ffdc21cd6f
https://doi.org/10.1016/s1097-2765(01)00210-6
https://doi.org/10.1016/s1097-2765(01)00210-6
Autor:
Vincent Moncollin, Bonnie L. Bertolaet, Duncan J. Clarke, Peter K. Kaiser, Mark H. Watson, Eric Bailly, Steven I. Reed
Publikováno v:
Genes & Development. 13:1190-1202
Cell cycle-specific proteolysis is critical for proper execution of mitosis in all eukaryotes. Ubiquitination and subsequent proteolysis of the mitotic regulators Clb2 and Pds1 depend on the cyclosome/APC and the 26S proteasome. We report here that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8494800a6abeab894911330522b1214d
https://doi.org/10.1101/gad.13.9.1190
https://doi.org/10.1101/gad.13.9.1190
Autor:
Richard J. Ulevitch, Richard I. Tapping, Shuang Huang, Mark H. Watson, Jiing Dwan Lee, Yutaka Kato
Publikováno v:
Nature. 395:713-716
Epidermal growth factor (EGF) induces cell proliferation in a variety of cell types by binding to a prototype transmembrane tyrosine kinase receptor. Ligation of this receptor by EGF activates Erk1 and Erk2, members of the mitogen-activated protein (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23679936207d2a3d49a39e6024cab9af
https://doi.org/10.1038/27234
https://doi.org/10.1038/27234
Autor:
Mark H. Watson, Michael J. Hickey, Yves Bourne, William D. Holmes, John A. Tainer, Warren J. Rocque, Steven I. Reed
Publikováno v:
Cell. 84:863-874
The 2.6 Angstrom crystal structure for human cyclin-dependent kinase 2(CDK2) in complex with CksHs1, a human homolog of essential yeast cell cycle-regulatory proteins suc1 and Cks1, reveals that CksHs1 binds via all four beta strands to the kinase C-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07bfa328277bfec27bddc3301474983
https://doi.org/10.1016/s0092-8674(00)81065-x
https://doi.org/10.1016/s0092-8674(00)81065-x
Publikováno v:
Journal of Hypertension. 11:483-490
OBJECTIVE The present investigation was undertaken to determine whether p34cdc2, a cell-cycle regulatory kinase, is involved in the manifestation of the altered proliferation evident in fibroblasts isolated from spontaneously hypertensive rats (SHR).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d306dcc85876a6c7e18a44a7564aebe
https://doi.org/10.1097/00004872-199305000-00003
https://doi.org/10.1097/00004872-199305000-00003
Publikováno v:
Journal of Biological Chemistry. 267:22853-22859
Smooth muscle caldesmon was phosphorylated in vitro by sea star p44mpk up to 2.0 mol of phosphate/mol of protein at both Ser and Thr residues. The phosphorylation sites were contained mainly in the COOH-terminal 10-kDa cyanogen bromide fragment which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb14dc8707df52d32e3a23250498ba6f
https://doi.org/10.1016/s0021-9258(18)50025-9
https://doi.org/10.1016/s0021-9258(18)50025-9
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1121:41-46
The interaction between chicken gizzard calponin and tropomyosin was examined using viscosity, light scattering, electron microscopy and affinity chromatography. At neutral pH, 10 mM NaCl and in the absence of Mg2+, calponin induced tropomyosin filam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42857acb56948cbe0fdeedb295dfe57
https://doi.org/10.1016/0167-4838(92)90334-a
https://doi.org/10.1016/0167-4838(92)90334-a