Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mark H. Pausch"'
Autor:
Christina N. DiMarco, Anthony L. Gotter, Alan T. Savitz, Joanne Stevens, Joseph G. Bruno, Tamara D. Cabalu, John J. Renger, Jason W. Skudlarek, Pamela L. Tannenbaum, Paul J. Coleman, Scott D. Kuduk, Joseph Brunner, Susan L. Garson, Christopher J. Winrow, Julie A. O'Brien, Charles M. Harrell, Mark H. Pausch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:2488-2492
Antagonism of orexin receptors has shown clinical efficacy as a novel paradigm for the treatment of insomnia and related disorders. Herein, molecules related to the dual orexin receptor antagonist filorexant were transformed into compounds that were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acadb1d22021c26105aca8a6acbc634
https://doi.org/10.1016/j.bmcl.2015.04.066
https://doi.org/10.1016/j.bmcl.2015.04.066
Autor:
Steven M. Grauer, Peter J. Atkinson, Michael A. Olsen, Cody Kelley, Deborah L. Smith, Margaret Lai, Guoming Zhang, Feng Liu, Sharon Rosenzweig-Lipson, Chad E. Beyer, Michael Popiolek, Adam M. Gilbert, Mark Day, Karen L. Marquis, Radka Graf, Rachel Navarra, Claudine Pulicicchio, Farhana Pruthi, Xavier Z. Khawaja, Evguenia Kouranova, Sheree F. Logue, Tom A. Comery, Caitlin Wantuch, Mark H. Pausch, Nicholas J. Brandon
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 327:827-839
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor subtype 5 (mGlu5) enhance N-methyl-d-aspartate receptor function and may represent a novel approach for the treatment of schizophrenia. ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7619d349d85d8c5594fdd5c791082951
https://doi.org/10.1124/jpet.108.136580
https://doi.org/10.1124/jpet.108.136580
Autor:
Eugene Tseng, Ying Sun, Maria Blatcher, Jeremy Johnson, Lynn Zhang, Noel Taylor, Sreekumar Raman Kodangattil, Janet E. Paulsen, Stan P. Nawoschik, Brian Bates, David C. Kopsco, Angela Kramer, Hui Min Chen, Qin Shan, Mark H. Pausch
Publikováno v:
Brain Research. 1087:1-14
This report describes the identification and characterization of the murine orphan GPCR, Gpr101. Both human and murine genes were localized to chromosome X. Similar to its human ortholog, murine Gpr101 mRNA was detected predominantly in the brain wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68aa573964a7f769dbd226062e205f70
https://doi.org/10.1016/j.brainres.2006.02.123
https://doi.org/10.1016/j.brainres.2006.02.123
Publikováno v:
Bioinformatics. 20:3490-3499
Motivation: Determining the coupling specificity of G-protein coupled receptors (GPCRs) is important for understanding the biology of this class of pharmacologically important proteins. Currently available in silico methods for predicting GPCR–G-pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3d9f6da79c63e82d4821db765554d2
https://doi.org/10.1093/bioinformatics/bth434
https://doi.org/10.1093/bioinformatics/bth434
Publikováno v:
Journal of Biological Chemistry. 278:47466-47476
G protein-coupled receptor kinases (GRKs) specifically bind and phosphorylate the agonist-occupied form of G protein-coupled receptors. To further characterize the mechanism of GRK/receptor interaction, we developed a yeast-based bioassay using strai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::782c82cedf9e4a611cfa06ec7ec3e108
https://doi.org/10.1074/jbc.m308257200
https://doi.org/10.1074/jbc.m308257200
Publikováno v:
Journal of Neurochemistry. 77:1327-1337
The goal of this study was to functionally express the three G(q)-coupled muscarinic receptor subtypes, M(1), M(3) and M(5), in yeast (Saccharomyces cerevisiae). Transformation of yeast with expression constructs coding for the full-length receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a4c07838d314854755310f0f5623d75
https://doi.org/10.1046/j.1471-4159.2001.00344.x
https://doi.org/10.1046/j.1471-4159.2001.00344.x
Autor:
Danielle Raufaste, Clarice Schmidt, Mark H. Pausch, Evi Kostenis, Claudine Serradeil-Le Gal, Jürgen Wess, Mark E. Dumont, Isolde Erlenbach
Publikováno v:
Journal of Biological Chemistry. 276:29382-29392
To facilitate structure-function relationship studies of the V2 vasopressin receptor, a prototypical G(s)-coupled receptor, we generated V2 receptor-expressing yeast strains (Saccharomyces cerevisiae) that required arginine vasopressin-dependent rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a918fc607f94d3eb5bcf6fde33a5b66c
https://doi.org/10.1074/jbc.m103203200
https://doi.org/10.1074/jbc.m103203200
Publikováno v:
Molecular and Cellular Biology. 15:6188-6195
A detailed analysis of structural and functional aspects of G-protein-coupled receptors, as well as discovery of novel pharmacophores that exert their effects on members of this class of receptors, will be facilitated by development of a yeast-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88dec5f7d2c84393e96cb9eb50395aeb
https://doi.org/10.1128/mcb.15.11.6188
https://doi.org/10.1128/mcb.15.11.6188
Autor:
Pranab K. Chanda, Eckart D. Gundelfinger, John F. Ross, Stephen J. Moss, Mark H. Pausch, Michael Popiolek, Erik I. Charych, Nicholas J. Brandon
Publikováno v:
The Journal of biological chemistry. 286(33)
Schizophrenia is a highly heritable neuropsychiatric disorder affecting ∼1% of the world's population. Linkage and association studies have identified multiple candidate schizophrenia susceptibility genes whose functions converge on the glutamaterg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22df65c67226db264a0f5131cec3c70
https://pubmed.ncbi.nlm.nih.gov/21700703
https://pubmed.ncbi.nlm.nih.gov/21700703
Autor:
Jean Zhang, Ping Zhou, Tikva Carrick, Albert J. Robichaud, Rolf Feenstra, Jan-Hendrik Reinders, Dianne Kowal, Chris G. Kruse, Martina A.W. van der Neut, Yinfa Yan, David P. Rotella, Mark H. Pausch, Margaret Lai, Karen L. Marquis
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(9)
A dihydroquinolinone moiety was found to be a potent serotonin reuptake inhibitor pharmacophore when combined with certain amines. This fragment was coupled with selected D2 ligands to prepare a series of dual acting compounds with attractive in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5166982a958128acf3a0153c1b0e0b45
https://pubmed.ncbi.nlm.nih.gov/20347298
https://pubmed.ncbi.nlm.nih.gov/20347298