Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mark H. L. Lambermon"'
Publikováno v:
Bioconjugate Chemistry. 19:1127-1131
In order to modify proteins in a controlled way, new functionalities need to be introduced in a defined manner. One way to accomplish this is by the incorporation of a non-natural amino acid of which the side chain can selectively be reacted to other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e076e747915df94233e4fed8bae9516
https://doi.org/10.1021/bc800019v
https://doi.org/10.1021/bc800019v
Autor:
Brian J. Cox, Brenton R. Graveley, Susan McCracken, Antonio Pineda-Lucena, John A. L. Bowman, Ying Lu, Cheryl H. Arrowsmith, Benjamin J. Blencowe, Blair R. Szymczyna, Mark H. L. Lambermon
Publikováno v:
Genes & Development. 17:461-475
The PWI motif is a highly conserved domain of unknown function in the SRm160 splicing and 3′-end cleavage-stimulatory factor, as well as in several other known or putative pre-mRNA processing components. We show here that the PWI motif is a new typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fe43c13f8c2c1d214d516160e0d964
https://doi.org/10.1101/gad.1060403
https://doi.org/10.1101/gad.1060403
Autor:
Michael Przybylski, David Westaway, Christopher Janus, Paul E. Fraser, Janet French, Amie L. Phinney, Mark H. L. Lambermon, Xiaodan Tian, Patrick Horne, Roxana Cecal, Audrey A. Darabie, Michael Brown, Marilena Manea, Meredith E. Kierstead, P. St. George-Hyslop, Howard T.J. Mount, M A Chishti, JoAnne McLaurin
Publikováno v:
Nature Medicine. 8:1263-1269
Immunization of transgenic mouse models of Alzheimer disease using amyloid-beta peptide (Abeta) reduces both the Alzheimer disease-like neuropathology and the spatial memory impairments of these mice. However, a therapeutic trial of immunization with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd97e74f50eecb658239ebbe3d567db6
https://doi.org/10.1038/nm790
https://doi.org/10.1038/nm790
Publikováno v:
Molecular and Cellular Biology. 22:148-160
Individual steps in the processing of pre-mRNA, including 5′-end cap formation, splicing, and 3′-end processing (cleavage and polyadenylation) are highly integrated and can influence one another. In addition, prior splicing can influence downstre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2039f59e285ab4241fbc5ba59ebd3b7
https://doi.org/10.1128/mcb.22.1.148-160.2002
https://doi.org/10.1128/mcb.22.1.148-160.2002
Autor:
Rob L.H. Nelissen, Jacqueline M. T. Klein Gunnewiek, Walther J. van Venrooij, Mark H. L. Lambermon
Publikováno v:
Gene. 184:273-278
Genes for the snRNP proteins U1-70K, U1-A, Sm-B′/B, Sm-D1 and Sm-E have been isolated from various metazoan species. The genes for Sm-D1 and Sm-E, which were isolated from a murine and human source respectively, appear to belong to a multigene fami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f323dfb7c35b5524872726e23eaf25
https://doi.org/10.1016/s0378-1119(96)00612-9
https://doi.org/10.1016/s0378-1119(96)00612-9
Publikováno v:
Journal of neurochemistry. 95(6)
Alzheimer's disease is characterized by amyloid deposits in the parenchyma and vasculature of the brain. The plaques are mainly composed of amyloid beta (Abeta) peptides ending in residues 40 and 42. Novel longer Abeta peptides were found in brain ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda37c9e7912026a55c17df3e5eb0ac7
https://pubmed.ncbi.nlm.nih.gov/16300644
https://pubmed.ncbi.nlm.nih.gov/16300644
Autor:
Audrey A. Darabie, Amie L. Phinney, Sydney S.N. Wong, Howard T.J. Mount, Jo Anne McLaurin, Peter St George-Hyslop, Michael Brown, Fusheng Chen, Mark H. L. Lambermon, Melissa F. Lan, Paul E. Fraser, Meredith E. Kierstead, Julian E. Cousins, Cheryl A. Hawkes, Janet French, David Westaway
Publikováno v:
Nature medicine. 12(7)
When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid beta peptide (Abeta) into high-molecular-weight oligomers in the brain and ameliorate several Alzheimer disease-like phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd1d493af6488541d5317d164b3489eb
https://pubmed.ncbi.nlm.nih.gov/16767098
https://pubmed.ncbi.nlm.nih.gov/16767098
Autor:
Mark H. L. Lambermon, Witold Filipowicz, Dominika A. Wieczorek Kirk, Marcel Dupasquier, Zdravko J. Lorković, Yu Fu
Nicotiana plumbaginifolia UBP1 is an hnRNP-like protein associated with the poly(A)(+) RNA in the cell nucleus. Consistent with a role in pre-mRNA processing, overexpression of UBP1 in N. plumabaginifolia protoplasts enhances the splicing of suboptim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efec4cf0f9e141896a3f85919fbb4940
https://europepmc.org/articles/PMC133861/
https://europepmc.org/articles/PMC133861/
Autor:
Maja Hemmings-Mieszczak, Ulrich Klahre, Gordon G. Simpson, Witold Filipowicz, Mark H. L. Lambermon, Dominika A. Wieczorek Kirk
Efficient splicing of higher plant pre-mRNAs depends on AU- or U-rich sequences in introns. Moreover, AU-rich sequences present in 3'-untranslated regions (3'-UTRs) may play a role in 3' end processing of plant mRNAs. Here, we describe the cloning an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4590f7d8495f7f72f2eb4c1d9f673213
https://europepmc.org/articles/PMC310232/
https://europepmc.org/articles/PMC310232/
Publikováno v:
Trends in plant science. 5(4)
Most plant mRNAs are synthesized as precursors containing one or more intervening sequences (introns) that are removed during the process of splicing. The basic mechanism of spliceosome assembly and intron excision is similar in all eukaryotes. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7259b2bae941ec0c2f1f22a4da0d6b6d
https://pubmed.ncbi.nlm.nih.gov/10740297
https://pubmed.ncbi.nlm.nih.gov/10740297