Výsledky vyhledávání - "Mark H Whitnall"

Akademický článek

The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates.

Autor: Vadim I Krivokrysenko, Ilia A Toshkov, Anatoli S Gleiberman, Peter Krasnov, Inna Shyshynova, Ivan Bespalov, Ratan K Maitra, Natalya V Narizhneva, Vijay K Singh, Mark H Whitnall, Andrei A Purmal, Alexander N Shakhov, Andrei V Gudkov, Elena Feinstein

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0135388 (2015)

There are currently no approved medical radiation countermeasures (MRC) to reduce the lethality of high-dose total body ionizing irradiation expected in nuclear emergencies. An ideal MRC would be effective even when administered well after radiation

Externí odkaz: https://doaj.org/article/6865a28f972e46fe8ca473ec1865cf65

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Akademický článek

Hematological changes as prognostic indicators of survival: similarities between Gottingen minipigs, humans, and other large animal models.

Autor: Maria Moroni, Eric Lombardini, Rudolph Salber, Mehdi Kazemzedeh, Vitaly Nagy, Cara Olsen, Mark H Whitnall

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e25210 (2011)

The animal efficacy rule addressing development of drugs for selected disease categories has pointed out the need to develop alternative large animal models. Based on this rule, the pathophysiology of the disease in the animal model must be well char

Externí odkaz: https://doaj.org/article/062755110b794fc3b8b9700075484094

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Akademický článek

δ-tocotrienol protects mouse and human hematopoietic progenitors from γ-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling

Autor: Xiang Hong Li, Dadin Fu, Nabil H. Latif, Conor P. Mullaney, Patrick H. Ney, Steven R. Mog, Mark H. Whitnall, Venkataraman Srinivasan, Mang Xiao

Publikováno v: Haematologica, Vol 95, Iss 12 (2010)

Background Exposure to γ-radiation causes rapid hematopoietic cell apoptosis and bone marrow suppression. However, there are no approved radiation countermeasures for the acute radiation syndrome. In this study, we demonstrated that natural δ-tocot

Externí odkaz: https://doaj.org/article/f0e1f024b1ef4a1ea5fc54dddeb6a8e5

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Bone Marrow Endothelial Cells Influence Function and Phenotype of Hematopoietic Stem and Progenitor Cells after Mixed Neutron/Gamma Radiation

Autor: Graça Almeida-Porada, Arthur Gross, Mark H. Whitnall, Daniel Noutai, Opeyemi Fadiyimu, Rudolph E. Salber, Lynnette H. Cary, Yared Kidane

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 20, Iss 7, p 1795 (2019)
Volume 20
Issue 7

The bone marrow (BM) microenvironment plays a crucial role in the maintenance and regeneration of hematopoietic stem (HSC) and progenitor cells (HSPC). In particular, the vascular niche is responsible for regulating HSC maintenance, differentiation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46f1ada7d0183ad6c2729f1e8aa4e33
http://europepmc.org/articles/PMC6480930

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Interactions between Endothelial Cells and T Cells Modulate Responses to Mixed Neutron/Gamma Radiation

Autor: Lynnette H. Cary, Mark H. Whitnall, Daniel Noutai, Barbara F. Ngudiankama, Margaret S. Williams, Rudolph E. Salber

Publikováno v: Radiation Research. 181:592-604

Detonation of an improvised nuclear device near a population center would cause significant casualties from the acute radiation syndrome (ARS) due to exposure to mixed neutron/gamma fields (MF). The pathophysiology of ARS involves inflammation, micro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d12d39204fd6c1ebf8af43455bc9719
https://doi.org/10.1667/rr13550.1

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Delta-Tocotrienol Protects Mice from Radiation-Induced Gastrointestinal Injury

Autor: Dadin Fu, Mang Xiao, Thomas B. Elliott, Vilmar Villa, Cam T. Ha, Mark H. Whitnall, Michael R. Landauer, Sanchita P. Ghosh, Xiang Hong Li, David L. Bolduc

Publikováno v: Radiation Research. 180:649-657

We recently demonstrated that natural delta-tocotrienol (DT3) significantly enhanced survival in total-body irradiated (TBI) mice, and protected mouse bone marrow cells from radiation-induced damage through Erk activation-associated mTOR survival pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16ac8baf5bcd12e363115b81dfed606
https://doi.org/10.1667/rr13398.1

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The Gottingen Minipig Is a Model of the Hematopoietic Acute Radiation Syndrome: G-Colony Stimulating Factor Stimulates Hematopoiesis and Enhances Survival From Lethal Total-Body γ-Irradiation

Autor: Cara H. Olsen, Christine Christensen, Mark H. Whitnall, Rebecca K. Holt, Barbara F. Ngudiankama, Rossitsa Owens, Eric D. Lombardini, Maria Moroni

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 86:986-992

Purpose We are characterizing the Gottingen minipig as an additional large animal model for advanced drug testing for the acute radiation syndrome (ARS) to enhance the discovery and development of novel radiation countermeasures. Among the advantages

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf7d15f7727e33f375fcdab16b7b911c
https://doi.org/10.1016/j.ijrobp.2013.04.041

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Evaluation of the Gamma-H2AX Assay for Radiation Biodosimetry in a Swine Model

Autor: Mark H. Whitnall, Christophe E. Redon, Daisuke Maeda, Maria Moroni, William M. Bonner

Publikováno v: International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 14119-14135 (2013)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 14; Issue 7; Pages: 14119-14135

There is a paucity of large animal models to study both the extent and the health risk of ionizing radiation exposure in humans. One promising candidate for such a model is the minipig. Here, we evaluate the minipig for its potential in γ-H2AX-based

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8891b6fd25bbf2ad7a6e8b8984d5e96e
https://doi.org/10.3390/ijms140714119

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5-AED enhances survival of irradiated mice in a G-CSF-dependent manner, stimulates innate immune cell function, reduces radiation-induced DNA damage and induces genes that modulate cell cycle progression and apoptosis

Autor: Tzu-Cheg Kao, Juong G. Rhee, Mark H. Whitnall, Marcy B. Grace, William E. Jackson, Vijay K. Singh

Publikováno v: Journal of Radiation Research

The steroid androst-5-ene-3ß,17ß-diol (5-androstenediol, 5-AED) elevates circulating granulocytes and platelets in animals and humans, and enhances survival during the acute radiation syndrome (ARS) in mice and non-human primates. 5-AED promotes su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::398e9f7e623505226f03e46d7df9f210
https://doi.org/10.1093/jrr/rrs060

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Role of radiation-induced granulocyte colony-stimulating factor in recovery from whole body gamma-irradiation

Autor: Oluseyi O. Fatanmi, Mark H. Whitnall, Vijay K. Singh, Pankaj Singh

Publikováno v: Cytokine. 58:406-414

The purpose of this study was to further elucidate the radioprotective role of granulocyte colony-stimulating factor (G-CSF) induced in response to irradiation. The induction of G-CSF and interleukin-6 (IL-6) in response to radiation exposure was eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdd417db361af69a5e8edaca75cae49
https://doi.org/10.1016/j.cyto.2012.03.011

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