Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Mark H Perrone"'
Publikováno v:
Mediators of Inflammation, Vol 2, Iss 1, Pp 85-92 (1993)
Using The globally ischaemic isolated guinea-pig heart we conducted studies to assess the role of activated neutrophils (PMNs) and the role of the endothelium in reperfusion injury. Reperfusion injury was induced by a 20 min period of global ischaemi
Externí odkaz:
https://doaj.org/article/fe62955377a44caba7bb94c73fa435fd
Autor:
Mark H. Perrone, Bruno X. Boutouyrie, Kenneth L. Clark, Linda Merkel, Michael F. Kelley, Peter N. Zannikos
Publikováno v:
Cardiovascular Drug Reviews. 18:183-210
The discovery that the endogenous autocoid adenosine plays a role in the ability of the myocardium to protect itself against ischemia has prompted a significant effort to identify stable cardioprotective adenosine agonists. This review summarizes cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1f04ac2526fbd3683d69d8c63365bb9
https://doi.org/10.1111/j.1527-3466.2000.tb00043.x
https://doi.org/10.1111/j.1527-3466.2000.tb00043.x
Autor:
Robert J. Leadley, Charles J Kasiewski, Ross Bentley, Suzanne R Morgan, Sam S. Rebello, Valeria Chu, Mark H Perrone
Publikováno v:
British Journal of Pharmacology. 133:1190-1198
We compared the antithrombotic efficacy of a potent factor Xa inhibitor, FXV673, to heparin and RPR109891, a GPIIb/IIIa antagonist, when used as adjunctive therapy in a canine model of rt-PA-induced coronary thrombolysis. Thrombus formation was induc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d27dcbba5981af603c48fbb8b0621af
https://doi.org/10.1038/sj.bjp.0704182
https://doi.org/10.1038/sj.bjp.0704182
Publikováno v:
European Journal of Pharmacology. 387:101-105
The aim of the study was to probe if acute administration of [1S-[1a, 2b,3b, 4a(S*)]]-4-[7-[[2-(3-chloro-2-thienyl)-1-methylpropyl]amino]-3H-imida zo[4,5-b] pyridin-3-yl] cyclopentane carboxamide (AMP 579) could provide a delayed protection against m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369834d19ff17cdb219e801553ac12cd
https://doi.org/10.1016/s0014-2999(99)00804-3
https://doi.org/10.1016/s0014-2999(99)00804-3
Autor:
Karen Brown, W. Ewing, Ross G. Bentley, Mark H. Perrone, Christopher L. Heran, Robert J. Leadley, Jeffrey S. Bostwick, Charles Kasiewski, Suzanne R Morgan, Spada Alfred P, Dunwiddie Christopher T, Valeria Chu, Phillip Moxey, Pauls Henry W
Publikováno v:
Journal of Cardiovascular Pharmacology. 34:791-799
These studies were designed to examine the pharmacodynamic profile and antithrombotic efficacy of RPR120844, a competitive inhibitor of coagulation factor Xa, with a K(i) of 7 nM against human factor Xa. In vitro, RPR120844 doubled activated partial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8cc715a3e27f800ed520f0de408258
https://doi.org/10.1097/00005344-199912000-00004
https://doi.org/10.1097/00005344-199912000-00004
Autor:
Alfred P. Spada, Robert J. Leadley, Jonathan S. Mason, Dennis J. Colussi, Ewing William R, Mark H. Perrone, Karen D. Brown, Michael R. Becker, Don D. Cha, Daniel M. Green, Ross Bentley, Henry W. Pauls, Christopher T. Dunwiddie, Jean-Pierre Guilloteau, Y.M. Choi-Sledeski, Sebastien Maignan, Mason Helen J, Vincent E. Manetta, Charles Kasiewski, Valeria Chu, Roderick S. Davis, Suzanne Morgan, Daniel L. Cheney, Jeff Bostwick
Publikováno v:
Journal of Medicinal Chemistry. 42:3557-3571
The discovery of a series of non-peptide factor Xa (FXa) inhibitors incorporating 3-(S)-amino-2-pyrrolidinone as a central template is described. After identifying compound 4, improvements in in vitro potency involved modifications of the liphophilic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2009f497bb352b54bc0c7e881834e15b
https://doi.org/10.1021/jm990040h
https://doi.org/10.1021/jm990040h
Autor:
Robert J. Leadley, Charles Kasiewski, Tara Wentz, Glenda E. Bilder, Jeffery Bostwick, Mark H. Perrone, Saul J. Needle, Betsey O’Conner, Christopher T. Dunwiddie, Lisa Byan, Kenneth Page, Helen Galczenski, Linda Merkel, Persons Paul E, Myers Michael R, Alfred P. Spada, Amin Dilip, Cuong Ly
Publikováno v:
Circulation. 99:3292-3299
Background —Platelet-derived growth factor (PDGF), a purported mediator of arterial response to injury, stimulates proliferation, chemotaxis, and matrix production by activation of its membrane receptor tyrosine kinase. Because these activities und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d180846942468a5df5011431ca5416
https://doi.org/10.1161/01.cir.99.25.3292
https://doi.org/10.1161/01.cir.99.25.3292
Autor:
Doan Kim-Anh Thi, Michael Jaye, Daniel J. Rader, Kevin J. Lynch, Dawn Marchadier, Mark H. Perrone, Amin Dilip, Cyrille Maugeais, Krawiec John A, South Victoria J
Publikováno v:
Nature Genetics. 21:424-428
High-density lipoprotein (HDL) cholesterol levels are inversely associated with risk of atherosclerotic cardiovascular disease. At least 50% of the variation in HDL cholesterol levels is genetically determined, but the genes responsible for variation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8247814a23299312cdae49a8c37b7c0
https://doi.org/10.1038/7766
https://doi.org/10.1038/7766
Autor:
Ewing William R, Robert J. Leadley, Alfred P. Spada, Mark H. Perrone, Christopher T. Dunwiddie, S. Morgan, Henry W. Pauls, Valeria Chu, Jeffrey S. Bostwick, Karen D. Brown, Ross Bentley
Publikováno v:
Thrombosis and Haemostasis. 81:157-160
SummaryThe in vivo antithrombotic activity of RPR120844, a novel synthetic coagulation factor Xa (fXa) inhibitor (Ki = 7 nM), was assessed by its ability to inhibit thrombus formation in a damaged segment of the rabbit jugular vein. Intravenous dose-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1ed83ecb09809b17f08abe7f2ff8cfa
https://doi.org/10.1055/s-0037-1614434
https://doi.org/10.1055/s-0037-1614434
Autor:
Alfred P. Spada, Mark H. Perrone, Fink Cynthia A, Kenneth L. Clark, Bryan F. Cox, Michael F. Jarvis, Glenn J. Smits, Camilo J. Rojas, Linda Merkel
Publikováno v:
Drug Development Research. 45:30-43
AMP 579 1S-[1α,2β,3β,4α(S*)]-4-[7-[[1 -[(3-chloro-2-thienyl)methyl]propylamino]-3H-imidazo[4,5-b]pyridin-3-yl]-N-ethyl-2,3-dihydroxy cyclopentanecarboxamide) is a novel cardioprotective adenosine agonist with the following order of affinity at ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b531c0d378a3a96c5bc770ecb2d6a74
https://doi.org/10.1002/(sici)1098-2299(199809)45:1<30::aid-ddr5>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199809)45:1<30::aid-ddr5>3.0.co