Zobrazeno 1 - 10
of 455
pro vyhledávání: '"Mark H, Ginsberg"'
Autor:
Ying Li, Romuald Girard, Abhinav Srinath, Diana Vera Cruz, Cezary Ciszewski, Chang Chen, Rhonda Lightle, Sharbel Romanos, Je Yeong Sone, Thomas Moore, Dorothy DeBiasse, Agnieszka Stadnik, Justine J. Lee, Robert Shenkar, Janne Koskimäki, Miguel A. Lopez-Ramirez, Douglas A. Marchuk, Mark H. Ginsberg, Mark L. Kahn, Changbin Shi, Issam A. Awad
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Cerebral cavernous malformation (CCM) is a hemorrhagic neurovascular disease with no currently available therapeutics. Prior evidence suggests that different cell types may play a role in CCM pathogenesis. The contribution of each cell type
Externí odkaz:
https://doaj.org/article/05cc7d1857bb4df3a29deb810717fcd3
Autor:
Hao Sun, Ho-Sup Lee, Sarah Hyun-Ji Kim, Mikhael Fernandes de Lima, Alexandre R. Gingras, Qinyi Du, Wilma McLaughlin, Jailail Ablack, Miguel A. Lopez-Ramirez, Frederic Lagarrigue, Zhichao Fan, John T. Chang, Derek VanDyke, Jamie B. Spangler, Mark H. Ginsberg
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112996- (2023)
Summary: Canonical interleukin-2 (IL-2) signaling via the high-affinity CD25-containing IL-2 receptor-Janus kinase (JAK)1,3-signal transducer and activator of transcription 5 (STAT5) pathway is essential for development and maintenance of CD4+CD25HiF
Externí odkaz:
https://doaj.org/article/198f78c69d0e49c48b1f20948a0bc3fb
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Integrins regulate the adhesion and migration of blood cells to ensure the proper positioning of these cells in the environment. Integrins detect physical and chemical stimuli in the extracellular matrix and regulate signaling pathways in blood cells
Externí odkaz:
https://doaj.org/article/fbb807f45f0349aab643773832440d90
Autor:
Kyle Spinler, Jeevisha Bajaj, Takahiro Ito, Bryan Zimdahl, Michael Hamilton, Armin Ahmadi, Claire S. Koechlein, Nikki Lytle, Hyog Young Kwon, Ferdous Anower-E-Khuda, Hao Sun, Allen Blevins, Joi Weeks, Marcie Kritzik, Jan Karlseder, Mark H. Ginsberg, Pyong Woo Park, Jeffrey D. Esko, Tannishtha Reya
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Identifying leukaemia stem cells (LSC) and defining how they drive tumourigenesis might aid in the treatment of disease. Here, the authors show that a reporter Musashi 2 can serve as a platform to effectively identify leukemic stem cells and it is us
Externí odkaz:
https://doaj.org/article/9cff1956974c4fd4bec74dfa1770589a
Autor:
Hao Sun, Wun Kuk, Jesús Rivera-Nieves, Miguel Alejandro Lopez-Ramirez, Lars Eckmann, Mark H. Ginsberg
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 369-385 (2020)
Background & Aims: Integrin α4β7 mediates lymphocyte trafficking to the gut and gut-associated lymphoid tissues, a process critical for recruitment of effector lymphocytes from the circulation to the gut mucosa in inflammatory bowel disease (IBD) a
Externí odkaz:
https://doaj.org/article/a61a7763d7044b87872bab3838b45c32
Autor:
Wenqing Li, Virginia Tran, Iftach Shaked, Belinda Xue, Thomas Moore, Rhonda Lightle, David Kleinfeld, Issam A Awad, Mark H Ginsberg
Publikováno v:
eLife, Vol 10 (2021)
Mosaic inactivation of CCM2 in humans causes cerebral cavernous malformations (CCMs) containing adjacent dilated blood-filled multi-cavernous lesions. We used CRISPR-Cas9 mutagenesis to induce mosaic inactivation of zebrafish ccm2 resulting in a nove
Externí odkaz:
https://doaj.org/article/85d99cab3cea493b919621e96939fdf1
Inefficient T-cell homing to tissues limits adoptive T-cell immunotherapy of solid tumors. αLβ2 and α4β1 integrins mediate trafficking of T cells into tissues via engagement of ICAM-1 and VCAM-1, respectively. Inhibiting protein kinase A (PKA)–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510bd34a8a8da59e5edffafa53470e9b
https://doi.org/10.1158/2326-6066.c.6548767.v1
https://doi.org/10.1158/2326-6066.c.6548767.v1
Supplemental Figure 1. Generation of the α4(S998A) mouse. Supplemental Figure 2. (A) Hematological analysis. B) Na?ve lymphoid organ lymphocyte subsets. C) Humoral immune response. Supplemental Figure 3. Intrinsic homing advantage of α4(S998A) sple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00007e429848815cc39a835f4f0b3a91
https://doi.org/10.1158/2326-6066.22538392.v1
https://doi.org/10.1158/2326-6066.22538392.v1
Supplementary Methods from PEA-15 Inhibits Tumor Cell Invasion by Binding to Extracellular Signal-Regulated Kinase 1/2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4f6b2a9557501bc7879ee62f20b875
https://doi.org/10.1158/0008-5472.22366169.v1
https://doi.org/10.1158/0008-5472.22366169.v1
Supplementary Figure 1 from PEA-15 Inhibits Tumor Cell Invasion by Binding to Extracellular Signal-Regulated Kinase 1/2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9087c2dafa41369321abdb71e0491f31
https://doi.org/10.1158/0008-5472.22366172.v1
https://doi.org/10.1158/0008-5472.22366172.v1