Genetic analysis of a novel tubulin mutation that redirects synaptic vesicle targeting and causes neurite degeneration in C. elegans.

Autor: Jiun-Min Hsu, Chun-Hao Chen, Yen-Chih Chen, Kent L McDonald, Mark Gurling, Albert Lee, Gian Garriga, Chun-Liang Pan

Publikováno v: PLoS Genetics, Vol 10, Iss 11, p e1004715 (2014)

Neuronal cargos are differentially targeted to either axons or dendrites, and this polarized cargo targeting critically depends on the interaction between microtubules and molecular motors. From a forward mutagenesis screen, we identified a gain-of-f

Externí odkaz: https://doaj.org/article/89434cdcff1844b693cd0c4d71180402

Precise and Heritable Genome Editing in Evolutionarily Diverse Nematodes Using TALENs and CRISPR/Cas9 to Engineer Insertions and Deletions

Autor: Edward J. Ralston, Qian Bian, Caitlin M. Schartner, Catherine S. Pickle, Mark Gurling, Jennifer A. Doudna, Te Wen Lo, Barbara J Meyer, Steven Lin

Publikováno v: Lo, TW; Pickle, CS; Lin, S; Ralston, EJ; Gurling, M; Schartner, CM; et al.(2013). Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions. Genetics, 195(2), 331-348. doi: 10.1534/genetics.113.155382. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/268787zz

Exploitation of custom-designed nucleases to induce DNA double-strand breaks (DSBs) at genomic locations of choice has transformed our ability to edit genomes, regardless of their complexity. DSBs can trigger either error-prone repair pathways that i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde63efb1a69deb51bc28eb8c1e664f1
https://doi.org/10.1534/genetics.113.155382

The DEP domain-containing protein TOE-2 promotes apoptosis in the Q lineage of C. elegans through two distinct mechanisms

Autor: Karla Talavera, Mark Gurling, Gian Garriga

Publikováno v: Development (Cambridge, England). 141(13)

Neuroblast divisions in the nematode Caenorhabditis elegans often give rise to a larger neuron and a smaller cell that dies. We have previously identified genes that, when mutated, result in neuroblast divisions that generate daughter cells that are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8bda89094a8a6d889121814be682935
https://pubmed.ncbi.nlm.nih.gov/24961802

A cell cycle regulatory gene contributes to zebrafish somitogenesis

Autor: Katherine S. Brown, Mark Gurling, Sharon L. Amacher

Publikováno v: Developmental Biology. 306:438

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593b64eb50a11be096c13dc18aa251dd
https://doi.org/10.1016/j.ydbio.2007.03.484