Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Mark Groudine"'
Autor:
Jessica M. Halow, Rachel Byron, Megan S. Hogan, Raquel Ordoñez, Mark Groudine, M. A. Bender, John A. Stamatoyannopoulos, Matthew T. Maurano
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The functional consequences of variation in human regulatory DNA depend on the local chromatin environment and the cell/tissue context. Here the authors use highly diverged hybrid mice to study genetic effects on DNA accessibility in vivo across mult
Externí odkaz:
https://doaj.org/article/1d484e6b9c4d452395c7af6a519b4e6c
Autor:
Amy R Strom, Ronald J Biggs, Edward J Banigan, Xiaotao Wang, Katherine Chiu, Cameron Herman, Jimena Collado, Feng Yue, Joan C Ritland Politz, Leah J Tait, David Scalzo, Agnes Telling, Mark Groudine, Clifford P Brangwynne, John F Marko, Andrew D Stephens
Publikováno v:
eLife, Vol 10 (2021)
Chromatin, which consists of DNA and associated proteins, contains genetic information and is a mechanical component of the nucleus. Heterochromatic histone methylation controls nucleus and chromosome stiffness, but the contribution of heterochromati
Externí odkaz:
https://doaj.org/article/7e515497572943718908128a28128049
Autor:
Brianna J. Klein, Lianhua Piao, Yuanxin Xi, Hector Rincon-Arano, Scott B. Rothbart, Danni Peng, Hong Wen, Connie Larson, Xi Zhang, Xia Zheng, Michael A. Cortazar, Pedro V. Peña, Anthony Mangan, David L. Bentley, Brian D. Strahl, Mark Groudine, Wei Li, Xiaobing Shi, Tatiana G. Kutateladze
Publikováno v:
Cell Reports, Vol 6, Iss 2, Pp 325-335 (2014)
The histone lysine demethylase KDM5B regulates gene transcription and cell differentiation and is implicated in carcinogenesis. It contains multiple conserved chromatin-associated domains, including three PHD fingers of unknown function. Here, we sho
Externí odkaz:
https://doaj.org/article/6020e060ae4b4bf5bff415985c40207c
Autor:
Jovylyn Gatchalian, Agnes Fütterer, Scott B. Rothbart, Qiong Tong, Hector Rincon-Arano, Ainhoa Sánchez de Diego, Mark Groudine, Brian D. Strahl, Carlos Martínez-A, Karel H.M. van Wely, Tatiana G. Kutateladze
Publikováno v:
Cell Reports, Vol 4, Iss 1, Pp 148-158 (2013)
Death Inducer Obliterator 3 (Dido3) is implicated in the maintenance of stem cell genomic stability and tumorigenesis. Here, we show that Dido3 regulates the expression of stemness genes in embryonic stem cells through its plant homeodomain (PHD) fin
Externí odkaz:
https://doaj.org/article/54365761417545339b51bba8fc3cdc90
Publikováno v:
eLife, Vol 3 (2014)
RNA polymerase II (PolII) transcribes RNA within a chromatin context, with nucleosomes acting as barriers to transcription. Despite these barriers, transcription through chromatin in vivo is highly efficient, suggesting the existence of factors that
Externí odkaz:
https://doaj.org/article/b64502bcfc46458b9a82d68ba89a43a6
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 6, p e1002543 (2012)
Externí odkaz:
https://doaj.org/article/39f20a021d3243b79d717a074fca9b9b
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
The nuclei of differentiating cells exhibit several fundamental principles of self‐organization. They are composed of many dynamical units connected physically and functionally to each other—a complex network—and the different parts of the syst
Externí odkaz:
https://doaj.org/article/ce526fab2b10415481440f37aab9d0a1
Autor:
Steven T Kosak, David Scalzo, Sam V Alworth, Fusheng Li, Stephanie Palmer, Tariq Enver, James S J Lee, Mark Groudine
Publikováno v:
PLoS Biology, Vol 5, Iss 11, p e309 (2007)
Gene loci are found in nuclear subcompartments that are related to their expression status. For instance, silent genes are often localized to heterochromatin and the nuclear periphery, whereas active genes tend to be found in the nuclear center. Evid
Externí odkaz:
https://doaj.org/article/6fbbb082d8a840d5b2ff70558f20e746
Publikováno v:
PLoS Genetics, Vol 3, Iss 2, p e27 (2007)
The promoter regions of approximately 40% of genes in the human genome are embedded in CpG islands, CpG-rich regions that frequently extend on the order of one kb 3' of the transcription start site (TSS) region. CpGs 3' of the TSS of actively transcr
Externí odkaz:
https://doaj.org/article/b627f06793954db0abec4926ac76183a
Autor:
Joan C. Ritland Politz, Katherine Chiu, Mark Groudine, Feng Yue, Clifford P. Brangwynne, Xiaotao Wang, Andrew D. Stephens, David Scalzo, Ronald J Biggs, Leah J Tait, Edward J. Banigan, Amy R. Strom, John F. Marko, Agnes Telling, Cameron Herman, Jimena Collado
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Chromatin, which consists of DNA and associated proteins, contains genetic information and is a mechanical component of the nucleus. Heterochromatic histone methylation controls nucleus and chromosome stiffness, but the contribution of heterochromati