Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mark Gimbel"'
Autor:
Alexey Youssef, Nawara Kasso, Antonio Sergio Torloni, Michael Stanek, Tomislav Dragovich, Mark Gimbel, Fade Mahmoud
Publikováno v:
Case Reports in Hematology, Vol 2018 (2018)
Ipilimumab is a monoclonal antibody that enhances the efficacy of the immune system by targeting a cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), which is a protein receptor that downregulates the immune system. Nivolumab is also a humanized m
Externí odkaz:
https://doaj.org/article/082df3821aff478f95976351792430a2
Autor:
Tomislav Dragovich, Ramez Awad, Naveen Yarlagadda, Mark Gimbel, Sunilkumar Kakadia, Madappa N. Kundranda, Jiaxin Niu, Lida A. Mina, Fade Mahmoud, Boris G. Naraev
Publikováno v:
OncoTargets and therapy
Approximately 50% of melanomas harbor an activating BRAF mutation. Combined BRAF and MEK inhibitors such as dabrafenib and trametinib, vemurafenib and cobimetinib, and encorafenib and binimetinib are US Food and Drug Administration (FDA)-approved to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3635f700b2a75b692fdd86bafdff3265
https://doi.org/10.2147/ott.s182721
https://doi.org/10.2147/ott.s182721
Autor:
Melinda Morris, Philip B. Paty, Mark Gimbel, Shoshana Rosenberg, Sajid A. Khan, Zhaoshi Zeng, Kamran Idrees, Fangyong Li, Michael P. LaQuaglia, Geliang Gan, Jinru Shia
Publikováno v:
Journal of pediatric surgery. 51(11)
Colorectal cancer (CRC) diagnosed before age 30 years is a fatal disease whose biology remains poorly understood. To understand its pathogenesis, we compared molecular and clinical data in surgically treated early-age onset and adult onset patients.C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884e74fb77861be0f1e0cedd3ac93d4b
https://pubmed.ncbi.nlm.nih.gov/27558481
https://pubmed.ncbi.nlm.nih.gov/27558481
Autor:
Sajid A. Khan, Garrett M. Nash, Zhaoshi Zeng, Ann Forslund, Philip B. Paty, Jinru Shia, Francis Barany, Mark Gimbel, Shoshana Rosenberg, Li-Xuan Qin, Iyare Esemuede
Publikováno v:
Annals of Surgical Oncology. 17:3370-3378
In colorectal cancer (CRC), microsatellite instability (MSI) is a valuable marker of defective DNA mismatch repair that identifies cancers with distinct phenotypic properties, including favorable survival. However, the optimal assay for MSI status is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d145a0262a4b16572cc6257ffb318a
https://doi.org/10.1245/s10434-010-1147-4
https://doi.org/10.1245/s10434-010-1147-4
Autor:
Mark Gimbel, Francis Barany, Philip B. Paty, Jurg Ott, Zhaoshi Zeng, Garrett M. Nash, Mackevin I. Ndubuisi, Alfred M. Cohen, Daniel R. Nathanson
Publikováno v:
Annals of Surgical Oncology. 17:416-424
We examined two genetic markers established early in colorectal tumor development, microsatellite instability (MSI) and mutation of the KRAS proto-oncogene, to see if these genetic changes influence metastatic disease progression and survival.MSI and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f845ce290a0aec4ef0209c124dabf6
https://doi.org/10.1245/s10434-009-0713-0
https://doi.org/10.1245/s10434-009-0713-0
Autor:
Yuka Yamaguchi, Mark Gimbel, Ann Forslund, Zhaoshi Zeng, Chin-Tung Chen, Matthew D’Alessio, Sajid A. Khan, Eleanor Kuntz, Philip B. Paty, Alfred T. Culliford, Martin R. Weiser, Garrett M. Nash, Francis Barany
Publikováno v:
Cancer Letters. 265:258-269
The c-Met proto-oncogene encodes a receptor tyrosine kinase (TK) that promotes invasive tumor growth and metastasis. Recent studies show that the presence of c-Met gene amplification is predictive for selective c-Met TK inhibitors in gastric cancer a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e9199c876504ceb1388cec0e71588c
https://doi.org/10.1016/j.canlet.2008.02.049
https://doi.org/10.1016/j.canlet.2008.02.049
Autor:
Mark Gimbel, Zhaoshi Zeng, Mackevin I. Ndubuisi, Jinru Shia, Daniel R. Nathanson, Garrett M. Nash, Philip B. Paty, Nancy E. Kemeny
Publikováno v:
Annals of Surgical Oncology
Observational studies of patients with primary colorectal cancer have identified KRAS mutation as a marker of poor prognosis. To examine more directly whether KRAS mutations are associated with accelerated metastatic progression, we evaluated KRAS mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a81b0401c41521a627c9d3adf506466
https://pubmed.ncbi.nlm.nih.gov/19936842
https://pubmed.ncbi.nlm.nih.gov/19936842
Autor:
Philip B. Paty, Mark Gimbel
Publikováno v:
Clinical colorectal cancer. 4(1)
Local excision of rectal cancer is appealing because of its technical ease and excellent functional results, but concern over inadequate pathologic staging and inferior treatment outcomes when compared with radical surgery remain a major hurdle for i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77940959bffc00c02349be1122c06753
https://pubmed.ncbi.nlm.nih.gov/15207017
https://pubmed.ncbi.nlm.nih.gov/15207017
Autor:
Jinru Shia, Francis Barany, Y. Yamaguchi, Garrett M. Nash, Daniel R. Nathanson, Mackevin I. Ndubuisi, Alfred T. Culliford, Philip B. Paty, Mark Gimbel, Zhaoshi Zeng
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 21(16)
Purpose: In a series of hereditary nonpolyposis colorectal cancer (HNPCC) patients, we evaluated the sensitivities of the individual microsatellites recommended by the National Cancer Institute (NCI) consensus workshop for detection of high-frequency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217d445576eca800944595483d0df3ff
https://pubmed.ncbi.nlm.nih.gov/12915601
https://pubmed.ncbi.nlm.nih.gov/12915601
Publikováno v:
Breast cancer research and treatment. 57(2)
We have previously established a model for postmenopausal, hormone‐dependent breast cancer in nude mice which is responsive to both antiestrogens and aromatase inhibitors. In this model, MCF‐7 human breast carcinoma cells transfected with the aro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01646a3435b61499ca6bc8c7f569762
https://pubmed.ncbi.nlm.nih.gov/10598045
https://pubmed.ncbi.nlm.nih.gov/10598045