Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Mark G Alexandrow"'
Autor:
Philip G Wong, Sherry L Winter, Elena Zaika, Thinh V Cao, Umut Oguz, John M Koomen, Joyce L Hamlin, Mark G Alexandrow
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17533 (2011)
Little is known about mammalian preRC stoichiometry, the number of preRCs on chromosomes, and how this relates to replicon size and usage. We show here that, on average, each 100-kb of the mammalian genome contains a preRC composed of approximately o
Externí odkaz:
https://doaj.org/article/de18e5b1d85143e8874f041b4eb79e3a
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5462 (2009)
BACKGROUND: Control of the onset of DNA synthesis in mammalian cells requires the coordinated assembly and activation of the pre-Replication Complex. In order to understand the regulatory events controlling preRC dynamics, we have investigated how th
Externí odkaz:
https://doaj.org/article/90af07b7cbf4499bbd3b7fadb8f35638
Autor:
Darcy L. Welch, Brooke L. Fridley, Ling Cen, Jamie K. Teer, Sean J. Yoder, Fredrik Pettersson, Liping Xu, Chia-Ho Cheng, Yonghong Zhang, Mark G. Alexandrow, Shengyan Xiang, Mark Robertson-Tessi, Joel S. Brown, Jonathan Metts, Andrew S. Brohl, Damon R. Reed
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Osteosarcoma is the most common bone sarcoma in children and young adults. While universally delivered, chemotherapy only benefits roughly half of patients with localized disease. Increasingly, intratumoral heterogeneity is recognized as a s
Externí odkaz:
https://doaj.org/article/f7513fb0926f4a94b84dd06a5b81bbee
Publikováno v:
Oncogene
The replicative Cdc45-MCM-GINS (CMG) helicase is a large protein complex that functions in the DNA melting and unwinding steps as a component of replisomes during DNA replication in mammalian cells. Although the CMG performs this important role in ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422061f6908e59f426fe01a6fb063804
https://europepmc.org/articles/PMC9948756/
https://europepmc.org/articles/PMC9948756/
Autor:
Michael S. Isakoff, Robert A. Gatenby, Damon R. Reed, Rikesh J Makanji, David M. Loeb, Brooke L. Fridley, Mariyah Pressley, Jonathan Metts, Mark G. Alexandrow, Lars M. Wagner, Joel S. Brown, Ryan D. Roberts, Masanori Hayashi, Matteo Trucco
Publikováno v:
Cancer
Lessons from extinction can be used in trials designed to pursue a cure for cancer. When cancer cannot be cured, similar strategies may be unwise, and strategies that leverage the adaptations of cancer to therapy should be considered.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac80cc64ff6ff788003743dc8e125c21
https://doi.org/10.1002/cncr.32777
https://doi.org/10.1002/cncr.32777
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-15 (2019)
Communications Biology
Communications Biology
Myc-driven tumorigenesis involves a non-transcriptional role for Myc in over-activating replication origins. We show here that the mechanism underlying this process involves a direct role for Myc in activation of Cdc45-MCM-GINS (CMG) helicases at Myc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e3923dd0f06c753fbf70153fead97b
http://link.springer.com/article/10.1038/s42003-019-0353-2
http://link.springer.com/article/10.1038/s42003-019-0353-2
Autor:
Jessica A. Reusch, January M. Watters, Katerina Vrzalikova, Michelle Maurin, Lou-Ella M.M. Alexander, Paul Murray, Kenneth L. Wright, Mark G. Alexandrow, Brook S. Nepon-Sixt
Publikováno v:
Molecular Immunology. 91:8-16
B cell activation is dependent on a large increase in transcriptional output followed by focused expression on secreted immunoglobulin as the cell transitions to an antibody producing plasma cell. The rapid transcriptional induction is facilitated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49512ceec8d463f757aac995f0ba2eb1
https://doi.org/10.1016/j.molimm.2017.08.016
https://doi.org/10.1016/j.molimm.2017.08.016
Autor:
Jessica A. Reusch, Paul Murray, Michelle Maurin, January M. Watters, Brook S. Nepon-Sixt, Katerina Vrzalikova, Mark G. Alexandrow, Kenneth L. Wright, Lou-Ella M.M. Alexander
Publikováno v:
Data in Brief
Data in Brief, Vol 15, Iss, Pp 222-227 (2017)
Data in Brief, Vol 15, Iss, Pp 222-227 (2017)
The data presented here are related to the research article entitled âSelective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survivalâ (Alexander et al., 2017) [1]. The cited research arti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789884ad4a36a7124e62a5fa14cdd5c9
http://europepmc.org/articles/PMC5633249
http://europepmc.org/articles/PMC5633249
Autor:
Gregory Diorio, Michael J. Schell, Nagi B. Kumar, Jed W. Fahey, Wade Sexton, Andrew Leone, Mark G. Alexandrow
Publikováno v:
Oncotarget
// Andrew Leone 1 , Gregory Diorio 1 , Wade Sexton 1 , Michael Schell 2 , Mark Alexandrow 3 , Jed W. Fahey 4 and Nagi B. Kumar 5 1 Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Inc., Tampa, FL, USA 2 Biostatistics and Bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8293fe19492b61b83737fe0942766dad
http://europepmc.org/articles/PMC5471065
http://europepmc.org/articles/PMC5471065
Publikováno v:
Bio Protoc
Chromatin consists of compacted DNA in complex with proteins and contributes to the organization of DNA and its stability. Furthermore, chromatin plays key roles in regulating cellular processes such as DNA replication, transcription, DNA repair, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1256abc518e06ef20653cbbc02da2c43
https://europepmc.org/articles/PMC7854364/
https://europepmc.org/articles/PMC7854364/