Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Mark G, Midei"'
Autor:
Plamena R. Angelova, Kristin M. Andruska, Mark G. Midei, Mario Barilani, Paldeep Atwal, Oliver Tucher, Peter Milner, Frederic Heerinckx, Mikhail S. Shchepinov
Publikováno v:
Antioxidants, Vol 10, Iss 7, p 1021 (2021)
Progressive supranuclear palsy (PSP) is a progressive movement disorder associated with lipid peroxidation and intracerebral accumulation of tau. RT001 is a deuterium reinforced isotopologue of linoleic acid that prevents lipid peroxidation (LPO) thr
Externí odkaz:
https://doaj.org/article/e8659cfd4ff74cf387d8f09a350c6e5a
Autor:
Megan Yerton, Allison Winter, Anthony Kostov, Cassandra Lieberman, Dario Gelevski, Harli Weber, Michael Doyle, Geli Kane, Neil Parikh, Katherine M. Burke, Margot Rohrer, Taylor Stirrat, Margaret Bruno, Alison Hochman, Sarah Luppino, Jennifer Scalia, Debra Skoniecki, Derek D'Agostino, Ervin Sinani, Hong Yu, Alexander V. Sherman, Suma Babu, James D. Berry, Mark G. Midei, Peter G. Milner, Merit E. Cudkowicz, Sabrina Paganoni
Publikováno v:
Musclenerve. 66(4)
Lipid peroxidation is thought to play a biologically important role in motor neuron death in amyotrophic lateral sclerosis (ALS). 11,11 Di-deuterated linoleic ethyl ester (RT001) prevents lipid peroxidation in cellular and mitochondrial membranes. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf4763c25732f28449b3303b9da260b
https://pubmed.ncbi.nlm.nih.gov/35765222
https://pubmed.ncbi.nlm.nih.gov/35765222
Autor:
Mark G. Midei, Lex van der Ploeg, Mikhail S. Shchepinov, Paldeep S. Atwal, Frederic Heerinckx, Peter Milner, Karsten Schmidt, Genevieve James, Robert Fielding, J. Thomas Brenna
Publikováno v:
Journal of Pharmaceutical Sciences. 109:3496-3503
RT001 is the di-deutero isotopologue of linoleic acid ethyl ester (D2-LA). Resistance to oxidative damage at the carbon-deuterium bond depends upon the concentration of D2-LA as a percentage of total LA. We report here on the plasma and red cell (RBC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2202a0c3ff3cf9582f6ed0b24dc5481d
https://doi.org/10.1016/j.xphs.2020.08.019
https://doi.org/10.1016/j.xphs.2020.08.019
Autor:
Mark G. Midei, Paldeep S. Atwal, Mario Barilani, Kristin M. Andruska, Oliver Tucher, Plamena R. Angelova, Frederic Heerinckx, Mikhail S. Shchepinov, Peter Milner
Publikováno v:
Antioxidants
Volume 10
Issue 7
Antioxidants, Vol 10, Iss 1021, p 1021 (2021)
Volume 10
Issue 7
Antioxidants, Vol 10, Iss 1021, p 1021 (2021)
Background: Progressive supranuclear palsy (PSP) is a progressive movement disorder associated with lipid peroxidation and intracerebral accumulation of tau. RT001 is a deuterium reinforced isotopologue of linoleic acid that prevents lipid peroxidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92e02d2b5af2fb8d82ed58935319d67
Autor:
Greg Ayers, Jean-Philippe Couderc, Randy Brown, Philip T. Sager, Mark G. Midei, William Daly, A. John Camm, Georg Ferber, Borje Darpo
Publikováno v:
Journal of clinical pharmacologyReferences. 61(12)
Perhexiline has been used to treat hypertrophic cardiomyopathy. In addition to its effect on carnitine-palmitoyltransferase-1, it has mixed ion channel effects through inhibition of several cardiac ion currents. Effects on cardiac ion channels expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a3254a357e685a981d11fc4c5f1137
https://pubmed.ncbi.nlm.nih.gov/34214210
https://pubmed.ncbi.nlm.nih.gov/34214210
Autor:
Darius J. Adams, Peter G. Milner, Frederic Heerinckx, Mark G. Midei, Paldeep S. Atwal, Alex J. Fay
Publikováno v:
Orphanet journal of rare diseases, vol 15, iss 1
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-9 (2020)
Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-9 (2020)
Orphanet Journal of Rare Diseases
Background INAD is an autosomal recessive neurogenetic disorder caused by biallelic pathogenic variants in PLA2G6. The downstream enzyme, iPLA2, plays a critical role in cell membrane homeostasis by helping to regulate levels of phospholipids. The cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10a360422cab597eba3f486e5a8a7f3
https://doi.org/10.1186/s13023-020-01479-5
https://doi.org/10.1186/s13023-020-01479-5
Autor:
Fowzan S. Alkuraya, Peter Milner, Paldeep S. Atwal, Fadie D. Altuame, Mark G. Midei, Mohammad A. Al-Muhaizea, Gretchen Kissel Foskett, Mais Hashem, Sarah Endemann, Muddathir H. Hamad, Mustafa A. Salih
Publikováno v:
Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-12 (2020)
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-12 (2020)
Background Infantile neuroaxonal dystrophy (INAD) is a rapidly progressive neurodegenerative disorder of early onset causing premature death. It results from biallelic pathogenic variants in PLA2G6, which encodes a calcium-independent phospholipase A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154b04703e7353be85f4597d78252433
https://doi.org/10.21203/rs.2.19797/v2
https://doi.org/10.21203/rs.2.19797/v2
Publikováno v:
Trends in molecular medicine. 26(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9a2d0f05e249e7c9b5c03fea044c13
https://pubmed.ncbi.nlm.nih.gov/31727544
https://pubmed.ncbi.nlm.nih.gov/31727544
Pharmacokinetics and pharmacodynamics of tecarfarin, a novel vitamin K antagonist oral anticoagulant
Autor:
David J. Ellis, Mark G. Midei, Daniel M. Canafax, Daniel Combs, Detlef Albrecht, Pascal Druzgala, Peter G. Milner
Publikováno v:
Thrombosis and Haemostasis. 117:706-717
SummaryTecarfarin is a vitamin K antagonist (VKA) with reduced propensity for drug interactions. To evaluate the pharmacokinetic (PK), pharmacodynamic (PD), and safety of tecarfarin, we performed single ascending dose (SAD) (n=66), multiple ascending
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de71481c7bb51e1d155b037bec4c2ef6
https://doi.org/10.1160/th16-08-0623
https://doi.org/10.1160/th16-08-0623
Autor:
Mikhail S. Shchepinov, Peter G. Milner, Christina Flora, Robert J. Molinari, Darius J. Adams, Mark G. Midei, Frederic Heerinckx, Paldeep S. Atwal, Sarah Endemann, Jahannaz Dastgir
Publikováno v:
JIMD Reports
JIMD Reports, Vol 54, Iss 1, Pp 54-60 (2020)
JIMD Reports, Vol 54, Iss 1, Pp 54-60 (2020)
Background Infantile neuroaxonal dystrophy (INAD) is a rare, autosomal recessive disease due to defects in PLA2G6 and is associated with lipid peroxidation. RT001 is a di‐deuterated form of linoleic acid that protects lipids from oxidative damage.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e40edd220f3ecdc8a4ca30a24319e3a4
https://pubmed.ncbi.nlm.nih.gov/32685351
https://pubmed.ncbi.nlm.nih.gov/32685351