Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Mark G, Bures"'
Autor:
Joseph D. Ho, Michelle C. Vargas, Jing Wang, Junliang Hao, Shane Atwell, James A. Monn, Sheela Ashok, Mark G. Bures, Qi Chen, Jeffery M. Schkeryantz
Publikováno v:
Journal of Medicinal Chemistry. 61:10040-10052
( S)-3,4-Dicarboxyphenylglycine (DCPG) was first reported in 2001 as a potent orthosteric agonist with high subtype selectivity for the mGlu8 receptor, but the structural basis for its high selectivity is not well understood. We have solved a cocryst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33be9a640f18a032be5e1bd51cd0d5b7
https://doi.org/10.1021/acs.jmedchem.8b01120
https://doi.org/10.1021/acs.jmedchem.8b01120
Autor:
Charles H. Mitch, Aiping Zhang, Mercedes Carpintero, Bradley Condon, C. Groshong, Shane Atwell, John W. Koss, Carl D Overshiner, Jeffrey M. Schkeryantz, Stephon C. Smith, Mark G. Bures, James E. Matt, S.R. Wasserman, Adam M. Fivush, Wesley Seidel, Carlos Jaramillo, K. Conners, David W. Bedwell, Jeffrey M. Witkin, Maria-Jesus Blanco, Daniel Ray Mayhugh, Steven James Quimby, Bruce A. Dressman, Keith A. Wafford, John T. Catlow, Allie Edward Tripp, Paul L. Ornstein, Mario Barberis, José Francisco Soriano, Steven Swanson, Beverly A. Heinz, Jon A. Erickson, Xia Li, Iain MacEwan, Thomas C. Britton, James A. Monn, Susana García-Cerrada, Jing Wang, Mark Donald Chappell, Eric George Tromiczak, Renhua Li, José Eugenio de Diego, Christine Sougias, Tatiana Natali Vetman, Xushan Wang, Stephen Antonysamy
Publikováno v:
Journal of Medicinal Chemistry. 59:10974-10993
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::812f4203afd8777afc4ec3e0d87f74f0
https://doi.org/10.1021/acs.jmedchem.6b01119
https://doi.org/10.1021/acs.jmedchem.6b01119
Publikováno v:
Methods. 93:41-50
Protein function prediction is an active area of research in computational biology. Function prediction can help biologists make hypotheses for characterization of genes and help interpret biological assays, and thus is a productive area for collabor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::933a0b72a67045b7e3cb13a7ad3102da
https://doi.org/10.1016/j.ymeth.2015.09.026
https://doi.org/10.1016/j.ymeth.2015.09.026
Autor:
David L. McKinzie, Bin Liu, Christian C. Felder, G. Stuart Gregory, Marla L. Watt, Robert E. Stratford, Carrie H. Croy, Hoogestraat Paul J, Jennifer R. Allen, James Andrew Jamison, Zhigang Rao, David A. Evans, William W. Turner, Frank P. Bymaster, Stephen Hitchcock, Mark G. Bures, Marvin M. Hansen, Fese M. Okha-Mokube
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4158-4163
The observation that cholinergic deafferentation of circuits projecting from forebrain basal nuclei to frontal and hippocampal circuits occurs in Alzheimer's disease has led to drug-targeting of muscarinic M1 receptors to alleviate cognitive symptoms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::460bbb7f85712e78446c74ee34c30d7f
https://doi.org/10.1016/j.bmcl.2015.08.011
https://doi.org/10.1016/j.bmcl.2015.08.011
Autor:
Mark G. Bures, David Edward Tupper, Joan H. Carter, James A. Monn, David L. McKinzie, Marijane Russell, Lourdes Prieto, Steven S. Henry, Reinhard Matthew Robert, Alicia Marcos, Lesley Walton, Christopher David Beadle, Bryan G. Johnson, Brian G. Getman, John T. Catlow, Frances Lu, Xushan Wang, Lorena Taboada, S. Richard Baker, Beverly A. Heinz, Helene Rudyk, David B. Shaw, Jaime Blanco, Carlos Lamas, Steven Swanson, David K. Clawson, Junliang Hao, Carlos Montero, Teresa Man, Shane Atwell, Barry Peter Clark, Jing Wang
Publikováno v:
Journal of Medicinal Chemistry. 58:7526-7548
Identification of orthosteric mGlu(2/3) receptor agonists capable of discriminating between individual mGlu2 and mGlu3 subtypes has been highly challenging owing to the glutamate-site sequence homology between these proteins. Herein we detail the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d4b305d2ec1acea2f3d473c73251c1
https://doi.org/10.1021/acs.jmedchem.5b01124
https://doi.org/10.1021/acs.jmedchem.5b01124
Publikováno v:
Molecules (Basel, Switzerland)
Molecules, Vol 20, Iss 7, Pp 12841-12862 (2015)
Molecules
Volume 20
Issue 7
Pages 12841-12862
Molecules, Vol 20, Iss 7, Pp 12841-12862 (2015)
Molecules
Volume 20
Issue 7
Pages 12841-12862
Virtual screening has been widely used in the drug discovery process. Ligand-based virtual screening (LBVS) methods compare a library of compounds with a known active ligand. Two notable advantages of LBVS methods are that they do not require structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e79b7a39b4ba8a637295837415b0cb
http://europepmc.org/articles/PMC5005041
http://europepmc.org/articles/PMC5005041
Autor:
Junliang Hao, Matt R. Reinhard, Barry Peter Clark, Jaime Blanco, Concepción Pedregal, Shane Atwell, Michael P. Johnson, Paul Goldsmith, Carlos Montero, Rosa Maria A. Simmons, James A. Monn, Steven Swanson, Chuanxi Xiang, Bryan G. Johnson, Frances Lu, Lorena Taboada, Teresa Man, David K. Clawson, Marijane Russell, Lesley Walton, Steven S. Henry, Jing Wang, Beverly A. Heinz, S. Richard Baker, Helen E. Sanger, Xushan Wang, David B. Shaw, Lourdes Prieto, Mark G. Bures, Joan H. Carter, Lisa M. Broad, Kelly L. Knopp, Helene Rudyk, David L. McKinzie, David Edward Tupper, Christopher David Beadle, John T. Catlow, Carlos Lamas, Alicia Marcos
Publikováno v:
Journal of Medicinal Chemistry. 58:1776-1794
As part of our ongoing research to identify novel agents acting at metabotropic glutamate 2 (mGlu2) and 3 (mGlu3) receptors, we have previously reported the identification of the C4α-methyl analog of mGlu2/3 receptor agonist 1 (LY354740). This molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::527bce29ceb86979086e1027b9d87633
https://doi.org/10.1021/jm501612y
https://doi.org/10.1021/jm501612y
Publikováno v:
International Journal of Molecular Sciences; Volume 15; Issue 9; Pages: 15122-15145
International Journal of Molecular Sciences, Vol 15, Iss 9, Pp 15122-15145 (2014)
International Journal of Molecular Sciences
Department of Biological Sciences Faculty Publications
International Journal of Molecular Sciences, Vol 15, Iss 9, Pp 15122-15145 (2014)
International Journal of Molecular Sciences
Department of Biological Sciences Faculty Publications
Structure-based computational methods have been widely used in exploring protein-ligand interactions, including predicting the binding ligands of a given protein based on their structural complementarity. Compared to other protein and ligand represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ecfd92c7b587670b145fd0385c6b6b
https://doi.org/10.3390/ijms150915122
https://doi.org/10.3390/ijms150915122
Autor:
Mark D, Chappell, Renhua, Li, Stephon C, Smith, Bruce A, Dressman, Eric G, Tromiczak, Allie E, Tripp, Maria-Jesus, Blanco, Tatiana, Vetman, Steven J, Quimby, James, Matt, Thomas C, Britton, Adam M, Fivush, Jeffrey M, Schkeryantz, Daniel, Mayhugh, Jon A, Erickson, Mark G, Bures, Carlos, Jaramillo, Mercedes, Carpintero, José Eugenio de, Diego, Mario, Barberis, Susana, Garcia-Cerrada, José F, Soriano, Stephen, Antonysamy, Shane, Atwell, Iain, MacEwan, Bradley, Condon, Christine, Sougias, Jing, Wang, Aiping, Zhang, Kris, Conners, Chris, Groshong, Stephen R, Wasserman, John W, Koss, Jeffrey M, Witkin, Xia, Li, Carl, Overshiner, Keith A, Wafford, Wesley, Seidel, Xu-Shan, Wang, Beverly A, Heinz, Steven, Swanson, John T, Catlow, David W, Bedwell, James A, Monn, Charles H, Mitch, Paul L, Ornstein
Publikováno v:
Journal of medicinal chemistry. 59(24)
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5baf0617bc8dab1818e329dffd2bc0c6
https://pubmed.ncbi.nlm.nih.gov/28002967
https://pubmed.ncbi.nlm.nih.gov/28002967
Autor:
Reinhard Matthew Robert, James A. Monn, Bryan G. Johnson, Xushan Wang, Matthew John Valli, Beverly A. Heinz, Mark G. Bures, Steven S. Henry, Brian G. Getman, Joan H. Carter, John T. Catlow, Junliang Hao, David L. McKinzie, Steven Marc Massey, Marc Herin, Steven Swanson, Gregory A. Stephenson
Publikováno v:
Journal of Medicinal Chemistry. 56:4442-4455
As part of our ongoing interest in identifying novel agonists acting at metabotropic glutamate (mGlu) 2/3 receptors, we have explored the effect of structural modifications of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740), a po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252437b5f6b3182bbac062c1d85eb12a
https://doi.org/10.1021/jm4000165
https://doi.org/10.1021/jm4000165