Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Mark F. Maurer"'
Autor:
Mark F. Maurer, Katherine E. Lewis, Joseph L. Kuijper, Dan Ardourel, Chelsea J. Gudgeon, Siddarth Chandrasekaran, Sherri L. Mudri, Kayla N. Kleist, Chris Navas, Martin F. Wolfson, Mark W. Rixon, Ryan Swanson, Stacey R. Dillon, Steven D. Levin, Yengo Raymond Kimbung, Masato Akutsu, Derek T. Logan, Björn Walse, Kristine M. Swiderek, Stanford L. Peng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
CD28 costimulatory signalling can be suppressed by immune checkpoints, such as CTLA-4 and PD-1. Here the authors describe the design of the fusion therapeutic davoceticept (ALPN-202), based on a variant CD80 extracellular domain engineered to bind PD
Externí odkaz:
https://doaj.org/article/1c1e0e459c4147429eef80ef95841f04
Autor:
Z. Goldberg, Pamela M. Holland, Stanford L. Peng, Gary Means, Lori Blanchfield, Mark F. Maurer, Sherri Mudri, Chelsea J. Gudgeon, Stacey R. Dillon, Jing Yang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundPreclinical evidence supports combining checkpoint inhibition (CPI) with T cell costimulatory agonism to improve the breadth and durability of anti-tumor responses relative to CPI alone. Currently, there are a number of therapeutic approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee3bd6c796d547728391a1b6e0f3109
https://doaj.org/article/c8021284446649e989e2921b9cb13fd1
https://doaj.org/article/c8021284446649e989e2921b9cb13fd1
Autor:
Siddarth Chandrasekaran, Demonte Daniel William, Logan Garrett, Stanford L. Peng, Ardourel Daniel F, Katherine E. Lewis, Sherri Mudri, Mark F. Maurer, Kayla N. Kleist, Michelle A. Seaberg, Jing Yang, Steven D. Levin, Mark W. Rixon, Joseph L. Kuijper, Rachel Wang, Stacey R. Dillon, Hieu Nguyen, Chelsea J. Gudgeon, Martin F. Wolfson
Publikováno v:
Cancer Research. 81:1740-1740
Introduction: Checkpoint inhibition (CPI) has been shown to be an effective anti-tumor therapy, but CPI alone is frequently insufficient to control tumor growth, and costimulatory signals may also be required to produce clinically significant anti-tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad26d42c81f0996e63429f20a500526e
https://doi.org/10.1158/1538-7445.am2021-1740
https://doi.org/10.1158/1538-7445.am2021-1740
Autor:
Kristine M. Swiderek, Siddarth Chandrasekaran, Stanford L. Peng, Katherine E. Lewis, Steven D. Levin, Fariha Ahmed-Qadri, Sherri Mudri, Chelsea J. Gudgeon, Kayla N. Kleist, Stacey R. Dillon, Mark F. Maurer
Publikováno v:
Cancer Research. 80:LB-085
Background: Despite significant clinical benefit of checkpoint inhibitors (CPI) in some settings, unfortunately, the majority of patients still fail to respond and/or develop resistance. This is likely due to a complex set of factors including, but n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac9eadb257650bb7d4c069a5fd55fe08
https://doi.org/10.1158/1538-7445.am2020-lb-085
https://doi.org/10.1158/1538-7445.am2020-lb-085
Autor:
Brent Meengs, Susan H. Julien, Ursula Garrigues, Thomas R. Bukowski, Stacey R. Dillon, Mark W. Rixon, Kenneth B. Lewis, Anitra C. Wolf, Mark Snavely, Mark F. Maurer, Stephen R. Jaspers, Brenda Stevens, Nels Hamacher
Publikováno v:
mAbs. 4:69-83
Interleukin-21 (IL-21) is a type I four-helical bundle cytokine that exerts a variety of significant effects on many hematopoietic cells, including T and B lymphocytes and natural killer cells. IL-21 is produced predominantly by CD4+ T cells and natu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d33f11da44554127aa68f9cceea88fa
https://doi.org/10.4161/mabs.4.1.18713
https://doi.org/10.4161/mabs.4.1.18713
Autor:
Stacey R. Dillon, Ryan Swanson, Steve D. Levin, Martin F. Wolfson, Mark F. Maurer, Chelsea J. Gudgeon, Chris L. Navas, Joseph L. Kuijper, Katherine E. Lewis, Michael Kornacker
Publikováno v:
Cancer Research. 78:4550-4550
Introduction: PD-1 pathway antagonists have revealed the importance of checkpoint pathways in regulating antitumor immunity, but an existing immune response is generally required for clinical efficacy. Specific T cell costimulation through CD28 is ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b8eea358913e2c204111044461c5dd5
https://doi.org/10.1158/1538-7445.am2018-4550
https://doi.org/10.1158/1538-7445.am2018-4550
Autor:
Steven D. Levin, Maryland Rosenfeld-Franklin, Stavros Topouzis, Rolf E. Kuestner, Don Foster, Brandon Harder, Tom Bukowski, Scott R. Presnell, Janet M. Kramer, Cosette LeCiel, Joseph L. Kuijper, Julia Parrish-Novak, Dennis L. Dong, Janet V. Johnston, Jane A. Gross, Kim Waggie, Francis J. Grant, Pamela Shea, Janine Bilsborough, Stacey R. Dillon, Cindy A. Sprecher, Sherri Mudri, Mark F. Maurer, Susan Bort, Harald S. Haugen, Heather Day, Maria M. Dasovich, Angela K. Hammond, Zhi Chen, Luann Lockwood
Publikováno v:
Nature Immunology. 5:752-760
T cell-derived cytokines are important in the development of an effective immune response, but when dysregulated they can promote disease. Here we identify a four-helix bundle cytokine we have called interleukin 31 (IL-31), which is preferentially pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e638cd5f3db65733291d0da5bbfb9a
https://doi.org/10.1038/ni1084
https://doi.org/10.1038/ni1084
Autor:
Wenfeng Xu, Maribeth A. Eagan, Ty Brender, Mark F. Maurer, Melanie K. Kuechle, Darrell C. Conklin, Angelika Grossmann, Yasmin A. Chandrasekher, Lena Yao, Laura J. Jelinek, Susan Carollo, Hal Blumberg, Kim Waggie, James D. Kelly, Cindy A. Sprecher, Julia Parrish-Novak, Theodore E. Whitmore, Betty A. Haldeman, Karen L. Madden, Beverly A. Dale, Don Foster, Donna E. Prunkard, Harald S. Haugen, Shannon L. Sexson, Angie Hammond, James W. West
Publikováno v:
Cell. 104(1):9-19
A structural, profile-based algorithm was used to identify interleukin 20 (IL-20), a novel IL-10 homolog. Chromosomal localization of IL-20 led to the discovery of an IL-10 family cytokine cluster. Overexpression of IL-20 in transgenic (TG) mice caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a2457d90ae0ea2e64234d99525e276
Autor:
Don Foster, Mark D. Heipel, Theodore E. Whitmore, Stacey R. Dillon, Margaret D. Moore, Susan Bort, Jane A. Gross, Cindy A. Sprecher, Karen L. Madden, Philippa J. Webster, Fenella C. Raymond, Janet V. Johnston, Cameron S. Brandt, Andrew Nelson, Teresa Gilbert, Kevin Hambly, Mark F. Maurer, Darrell C. Conklin, Sara K. Schrader, Francis J. Grant, Rick D. Holly, Andrew Ching, Wenfeng Xu, Sherri Mudri, Kenneth Kaushansky, Faith Shiota, Scott R. Presnell, Lena Yao, Angie Hammond, Catherine Lofton-Day, Steve K. Burkhead, Julia Parrish-Novak, Chris Clegg, Joseph L. Kuijper, Jon Berry, Deborah L. Smith, Janet M. Kramer, James A. West
Publikováno v:
Nature. 408:57-63
Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here we have identified a class I cytokine receptor that is selectively expressed in lymphoid tissues and is capable of signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445b2da411b32a6f2615ef16b37990b9
https://doi.org/10.1038/35040504
https://doi.org/10.1038/35040504
Autor:
Mark F. Maurer, Darrell C. Conklin, Theodore E. Whitmore, Susan D. Holderman, Andrew L. Feldhaus
Publikováno v:
Gene. 249:91-98
The sequence of the ubiquitin protein is highly conserved between species and has facilitated the cloning of numerous ubiquitin-like proteins. In the present study, we report the cloning of the cDNA for human ubiquilin 3 (UBQLN3). The deduced amino a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae778a97f43177cb40e9721a30fdb506
https://doi.org/10.1016/s0378-1119(00)00122-0
https://doi.org/10.1016/s0378-1119(00)00122-0