Zobrazeno 1 - 10
of 375
pro vyhledávání: '"Mark F Lythgoe"'
Autor:
Cassandra L Stowe, Thomas A Burley, Helen Allan, Maria Vinci, Gabriela Kramer-Marek, Daniela M Ciobota, Gary N Parkinson, Tara L Southworth, Giulia Agliardi, Alastair Hotblack, Mark F Lythgoe, Bruce R Branchini, Tammy L Kalber, James C Anderson, Martin A Pule
Publikováno v:
eLife, Vol 8 (2019)
Bioluminescence imaging (BLI) is ubiquitous in scientific research for the sensitive tracking of biological processes in small animal models. However, due to the attenuation of visible light by tissue, and the limited set of near-infrared bioluminesc
Externí odkaz:
https://doaj.org/article/28633a3c3ec14220bcd7ff7a3ce49ce3
Autor:
Ian F Harrison, Bernard Siow, Aisha B Akilo, Phoebe G Evans, Ozama Ismail, Yolanda Ohene, Payam Nahavandi, David L Thomas, Mark F Lythgoe, Jack A Wells
Publikováno v:
eLife, Vol 7 (2018)
The glymphatics system describes a CSF-mediated clearance pathway for the removal of potentially harmful molecules, such as amyloid beta, from the brain. As such, its components may represent new therapeutic targets to alleviate aberrant protein accu
Externí odkaz:
https://doaj.org/article/ac2ca34016804c4aa72b5387b52ac633
Autor:
Rajiv Ramasawmy, S Peter Johnson, Thomas A Roberts, Daniel J Stuckey, Anna L David, R Barbara Pedley, Mark F Lythgoe, Bernard Siow, Simon Walker-Samuel
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156162 (2016)
BACKGROUND:Research using orthotopic and transgenic models of cancer requires imaging methods to non-invasively quantify tumour burden. As the choice of appropriate imaging modality is wide-ranging, this study aimed to compare low-field (1T) magnetic
Externí odkaz:
https://doaj.org/article/848c45868605415b80e85dda1893c54e
Autor:
Nick M Powell, Marc Modat, M Jorge Cardoso, Da Ma, Holly E Holmes, Yichao Yu, James O'Callaghan, Jon O Cleary, Ben Sinclair, Frances K Wiseman, Victor L J Tybulewicz, Elizabeth M C Fisher, Mark F Lythgoe, Sébastien Ourselin
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162974 (2016)
We describe a fully automated pipeline for the morphometric phenotyping of mouse brains from μMRI data, and show its application to the Tc1 mouse model of Down syndrome, to identify new morphological phenotypes in the brain of this first transchromo
Externí odkaz:
https://doaj.org/article/695c75fdbdea4976bdb04201ec259b47
Autor:
Dawn E Watkins-Chow, Joanna Cooke, Ruth Pidsley, Andrew Edwards, Rebecca Slotkin, Karen E Leeds, Raymond Mullen, Laura L Baxter, Thomas G Campbell, Marion C Salzer, Laura Biondini, Gretchen Gibney, Françoise Phan Dinh Tuy, Jamel Chelly, H Douglas Morris, Johannes Riegler, Mark F Lythgoe, Ruth M Arkell, Fabrizio Loreni, Jonathan Flint, William J Pavan, David A Keays
Publikováno v:
PLoS Genetics, Vol 11, Iss 11, p e1005682 (2015)
Externí odkaz:
https://doaj.org/article/104fd857238b4b8189cbe2fd22c7a629
Autor:
Douglas M. Lopes, Jack A. Wells, Da Ma, Lauren Wallis, Daniel Park, Sophie K. Llewellyn, Zeshan Ahmed, Mark F. Lythgoe, Ian F. Harrison
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background The aggregation and spread of misfolded amyloid structured proteins, such as tau and α-synuclein, are key pathological features associated with neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. These
Externí odkaz:
https://doaj.org/article/65c062308a814af1b6467b6b5609aa1e
Autor:
Lauren Bourke, James McCormick, Valerie Taylor, Charis Pericleous, Benoit Blanchet, Nathalie Costedoat-Chalumeau, Daniel Stuckey, Mark F Lythgoe, Anastasis Stephanou, Yiannis Ioannou
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143771 (2015)
An increasing number of investigations including human studies demonstrate that pharmacological ischaemic preconditioning is a viable way to protect the heart from myocardial ischaemia/reperfusion (I/R) injury. This study investigated the role of hyd
Externí odkaz:
https://doaj.org/article/6984a75f58f8453083e9a4ae86d1b1d7
Autor:
Rachael A Panizzo, David G Gadian, Jane C Sowden, Jack A Wells, Mark F Lythgoe, Patrizia Ferretti
Publikováno v:
F1000Research, Vol 2 (2014)
Efficacy of neural stem/progenitor cell (NPC) therapies after cerebral ischaemia could be better evaluated by monitoring in vivo migration and distribution of cells post-engraftment in parallel with analysis of lesion volume and functional recovery.
Externí odkaz:
https://doaj.org/article/34869daec471411992940800f459f4ae
Autor:
Thomas A Roberts, Francesca C Norris, Helen Carnaghan, Dawn Savery, Jack A Wells, Bernard Siow, Peter J Scambler, Agostino Pierro, Paolo De Coppi, Simon Eaton, Mark F Lythgoe
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109143 (2014)
Mouse embryo imaging is conventionally carried out on ex vivo embryos excised from the amniotic sac, omitting vital structures and abnormalities external to the body. Here, we present an in amnio MR imaging methodology in which the mouse embryo is re
Externí odkaz:
https://doaj.org/article/82e80e3fb3284a14a1c36b9231e900e0
Autor:
Da Ma, Manuel J Cardoso, Marc Modat, Nick Powell, Jack Wells, Holly Holmes, Frances Wiseman, Victor Tybulewicz, Elizabeth Fisher, Mark F Lythgoe, Sébastien Ourselin
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86576 (2014)
Multi-atlas segmentation propagation has evolved quickly in recent years, becoming a state-of-the-art methodology for automatic parcellation of structural images. However, few studies have applied these methods to preclinical research. In this study,
Externí odkaz:
https://doaj.org/article/bf24f3a291d54aea8f00605c7160b887