Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Mark F Bear"'
Publikováno v:
eLife, Vol 10 (2021)
Monocular deprivation early in development causes amblyopia, a severe visual impairment. Prognosis is poor if therapy is initiated after an early critical period. However, clinical observations have shown that recovery from amblyopia can occur later
Externí odkaz:
https://doaj.org/article/f35720d382314c868ccdd3503f5c3c57
Autor:
James J. Fink, Nathaniel Delaney-Busch, Ryan Dawes, Evanthia Nanou, Christopher Folts, Karthiayani Harikrishnan, Chris Hempel, Hansini Upadhyay, Trinh Nguyen, Himali Shroff, David Stoppel, Steven J. Ryan, Jane Jacques, Jennifer Grooms, Elizabeth Berry-Kravis, Mark F. Bear, Luis A. Williams, David Gerber, Mark Bunnage, Brinley Furey, Graham T. Dempsey
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by hypermethylation of expanded CGG repeats (>200) in the FMR1 gene leading to gene silencing and loss of Fragile X Messenger Ribonucleoprotein (FMRP) expression. FMRP plays im
Externí odkaz:
https://doaj.org/article/4c3520c6a9254e29bb6412e3a3c39efa
Autor:
Eitan S Kaplan, Sam F Cooke, Robert W Komorowski, Alexander A Chubykin, Aurore Thomazeau, Lena A Khibnik, Jeffrey P Gavornik, Mark F Bear
Publikováno v:
eLife, Vol 5 (2016)
The roles played by cortical inhibitory neurons in experience-dependent plasticity are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of prim
Externí odkaz:
https://doaj.org/article/d5644dbadef34ef7abebf51f46762011
Autor:
Gordon B Smith, Mark F Bear
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 4 (2010)
Monocular visual deprivation (MD) produces profound changes in the ocular dominance (OD) of neurons in the visual cortex. MD shifts visually evoked responses away from the deprived eye and towards domination by the open eye. Over thirty years ago, tw
Externí odkaz:
https://doaj.org/article/1a89cc9d9d664f4685c670ee94f29943
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Amblyopia is a common visual impairment that develops during the early years of postnatal life. It emerges as a sequela to eye misalignment, an imbalanced refractive state, or obstruction to form vision. All of these conditions prevent normal vision
Externí odkaz:
https://doaj.org/article/08bc504da2d349d9b601d95fcab6b80c
Indispensable depuis plus de 20 ans, l'ouvrage Neurosciences, à la découverte du cerveau est la référence incontestée pour l'initiation et la formation aux sciences du cerveau. Cette 4e édition met en lumière des avancées majeures si bien qu'
Publikováno v:
Frontiers in Neural Circuits, Vol 15 (2022)
Stimulus-selective response plasticity (SRP) is a robust and lasting modification of primary visual cortex (V1) that occurs in response to exposure to novel visual stimuli. It is readily observed as a pronounced increase in the magnitude of visual ev
Externí odkaz:
https://doaj.org/article/b95e678efaa245f7952dabc12755cde1
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Fragile X syndrome (FXS) is caused by silencing of the human FMR1 gene and is the leading monogenic cause of intellectual disability and autism. Abundant preclinical data indicated that negative allosteric modulators (NAMs) of metabotropic glutamate
Externí odkaz:
https://doaj.org/article/d876a8e8eb874f5ea370bbe486d1786b
Publikováno v:
Current opinion in ophthalmology. 33(6)
We examine the development of amblyopia and the effectiveness of conventional and emerging therapies through the lens of the Bienenstock, Cooper, and Munro (BCM) theory of synaptic modification.The BCM theory posits metaplastic adjustment in the thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a83ba94417e31b1ce86d6df9c5a0ad
https://pubmed.ncbi.nlm.nih.gov/36094025
https://pubmed.ncbi.nlm.nih.gov/36094025
Autor:
Hector De Jesus-Cortes, Daniel A Bowen, Francis Reilly-Andujar, Sophie Lu, Eric D Gaier, Mark F. Bear
The visual cliff assay (VCA) has been used in multiple animal models including humans to assess stereopsis, the pinnacle percept of binocular function that is markedly disrupted in amblyopia. Amblyopia is a neurodevelopmental disorder of the visual s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc1257839ce592465bb94695214640b9
https://doi.org/10.1101/2023.05.29.542767
https://doi.org/10.1101/2023.05.29.542767