Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver.

Autor: Benjamin P Flynn, Matthew T Birnie, Yvonne M Kershaw, Audrys G Pauza, Sohyoung Kim, Songjoon Baek, Mark F Rogers, Alex R Paterson, Diana A Stavreva, David Murphy, Gordon L Hager, Stafford L Lightman, Becky L Conway-Campbell

Publikováno v: PLoS Genetics, Vol 17, Iss 8, p e1009737 (2021)

Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynam

Externí odkaz: https://doaj.org/article/ebb7253002144d5885d6bce3701f46a0

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development

Autor: Tom J. Phillips, Hannah Scott, David A. Menassa, Ashleigh L. Bignell, Aman Sood, Jude S. Morton, Takami Akagi, Koki Azuma, Mark F. Rogers, Catherine E. Gilmore, Gareth J. Inman, Simon Grant, Yealin Chung, Mais M. Aljunaidy, Christy-Lynn Cooke, Bruno R. Steinkraus, Andrew Pocklington, Angela Logan, Gavin P. Collett, Helena Kemp, Peter A. Holmans, Michael P. Murphy, Tudor A. Fulga, Andrew M. Coney, Mitsuru Akashi, Sandra T. Davidge, C. Patrick Case

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)

Abstract Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental oxidative stress. Here we investigated if gestational hypoxia promotes damaging secreti

Externí odkaz: https://doaj.org/article/b061c7fc2e2040a6b274efd65f22ba8a

Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver

Autor: Matthew T. Birnie, Alex Paterson, Diana A. Stavreva, YM Kershaw, Becky L. Conway-Campbell, Audrys G Pauza, Songjoon Baek, David Murphy, Mark F. Rogers, Benjamin P. Flynn, Sohyoung Kim, Gordon L. Hager, Stafford L. Lightman

Publikováno v: PLoS Genetics, Vol 17, Iss 8, p e1009737 (2021)
Flynn, B P, Birnie, M T, Kershaw, Y M, Pauza, A G, Kim, S, Baek, S, Rogers, M F, Paterson, A R, Stavreva, D A, Murphy, D, Hager, G L, Lightman, S L & Conway-Campbell, B L 2021, ' Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver ', PLoS Genetics, vol. 17, no. 8, e1009737, pp. e1009737 . https://doi.org/10.1371/journal.pgen.1009737
PLoS Genetics

Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ed6b521145c837c00c33b28a1f80b1
https://doaj.org/article/ebb7253002144d5885d6bce3701f46a0

Maternal antioxidant treatment prevents the adverse effects of prenatal stress on the offspring’s brain and behavior

Autor: Hannah Scott, Alessio Alfieri, Paula J. Brunton, Mark F. Rogers, C. P. Case, Thomas J. Phillips, V. Volpato, Ying Sze

Publikováno v: Scott, H, Phillips, T, Sze, Y, Alfieri, A, Rogers, M, Volpato, V, Case, P & Brunton, P 2020, ' Maternal antioxidant treatment prevents the adverse effects of prenatal stress on the offspring’s brain and behavior ', Neurobiology of Stress, vol. 13, pp. 100281 . https://doi.org/10.1016/j.ynstr.2020.100281
Neurobiology of Stress
Neurobiology of Stress, Vol 13, Iss, Pp 100281-(2020)

Maternal exposure to stress during pregnancy is associated with an increased risk of psychiatric disorders in the offspring in later life. The mechanisms through which the effects of maternal stress are transmitted to the fetus are unclear, however t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01f590c3059b68cd4b50e5b3d5f6781
https://hdl.handle.net/20.500.11820/24806ff4-7485-4533-a4fb-1c874ef04b99

Deciphering the plant splicing code: Experimental and computational approaches for predicting alternative splicing and splicing regulatory elements

Autor: Anireddy S.N. Reddy, Mark F Rogers, Dale N Richardson, Michael eHamilton, Asa eBen-Hur

Publikováno v: Frontiers in Plant Science, Vol 3 (2012)

Extensive alternative splicing (AS) of precursor mRNAs (pre-mRNAs) in multicellular eukaryotes increases the protein-coding capacity of a genome and allows novel ways to regulate gene expression. In fowering plants, up to 48% of intron-containing gen

Externí odkaz: https://doaj.org/article/2124c66a44ed4205a36f2d1466c4a876