Zobrazeno 1 - 10
of 347
pro vyhledávání: '"Mark F, Lythgoe"'
Autor:
Douglas M. Lopes, Jack A. Wells, Da Ma, Lauren Wallis, Daniel Park, Sophie K. Llewellyn, Zeshan Ahmed, Mark F. Lythgoe, Ian F. Harrison
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background The aggregation and spread of misfolded amyloid structured proteins, such as tau and α-synuclein, are key pathological features associated with neurodegenerative disorders, including Alzheimer’s and Parkinson’s disease. These
Externí odkaz:
https://doaj.org/article/65c062308a814af1b6467b6b5609aa1e
Autor:
Carlos Flechas Becerra, Lady V. Barrios Silva, Ebtehal Ahmed, Joseph C. Bear, Zhiping Feng, David Y.S. Chau, Samuel G. Parker, Steve Halligan, Mark F. Lythgoe, Daniel J. Stuckey, P. Stephen Patrick
Publikováno v:
Advanced Science, Vol 11, Iss 10, Pp n/a-n/a (2024)
Abstract Protein‐based biomaterial use is expanding within medicine, together with the demand to visualize their placement and behavior in vivo. However, current medical imaging techniques struggle to differentiate between protein‐based implants
Externí odkaz:
https://doaj.org/article/372a6e0721dc40598ef30a6a92b3ab66
Autor:
Stephanie Efthymiou, Wenyan Han, Muhammad Ilyas, Jun Li, Yichao Yu, Marcello Scala, Nancy T. Malintan, Nikoleta Vavouraki, Kshitij Mankad, Reza Maroofian, Clarissa Rocca, Vincenzo Salpietro, Shenela Lakhani, Eric J. Mallack, Timothy Blake Palculict, Hong Li, Guojun Zhang, Faisal Zafar, Nuzhat Rana, Noriko Takashima, Hayato Matsunaga, Claudia Manzoni, Pasquale Striano, Mark F. Lythgoe, Jun Aruga, Wei Lu, Henry Houlden
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
This study reports on biallelic homozygous and monoallelic de novo variants in SLITRK3 in three unrelated families presenting with epileptic encephalopathy associated with a broad neurological involvement characterized by microcephaly, intellectual d
Externí odkaz:
https://doaj.org/article/4c9fba0e92c64e6881b4e82760b9b3c3
Autor:
Andreas Christ Sølvsten Jørgensen, Ciaran Scott Hill, Marc Sturrock, Wenhao Tang, Saketh R. Karamched, Dunja Gorup, Mark F. Lythgoe, Simona Parrinello, Samuel Marguerat, Vahid Shahrezaei
Publikováno v:
Royal Society Open Science, Vol 10, Iss 3 (2023)
Mathematical oncology provides unique and invaluable insights into tumour growth on both the microscopic and macroscopic levels. This review presents state-of-the-art modelling techniques and focuses on their role in understanding glioblastoma, a mal
Externí odkaz:
https://doaj.org/article/8b9919107ff24d2fb30451167c82aeca
Autor:
Patrick S. Hosford, Jack A. Wells, Shereen Nizari, Isabel N. Christie, Shefeeq M. Theparambil, Pablo A. Castro, Anna Hadjihambi, L. Felipe Barros, Iván Ruminot, Mark F. Lythgoe, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The mechanism of neurovascular coupling ensures that the brain energy supply is sufficient to meet demand. Here the authors show that in this mechanism CO2 plays an important role in neuronal activity-dependent regulation of local brain blood flow.
Externí odkaz:
https://doaj.org/article/0e7fd82c54eb4eecb447c0bf5d5c893f
Autor:
Charith Perera, Daniele Tolomeo, Rebecca R. Baker, Yolanda Ohene, Alla Korsak, Mark F. Lythgoe, David L. Thomas, Jack A. Wells
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Chronic hypertension is a major risk factor for the development of neurodegenerative disease, yet the etiology of hypertension-driven neurodegeneration remains poorly understood. Forming a unique interface between the systemic circulation and the bra
Externí odkaz:
https://doaj.org/article/a9cfb96988374a9fa538e5809e844fa7
Autor:
Giulia Agliardi, Anna Rita Liuzzi, Alastair Hotblack, Donatella De Feo, Nicolás Núñez, Cassandra L. Stowe, Ekaterina Friebel, Francesco Nannini, Lukas Rindlisbacher, Thomas A. Roberts, Rajiv Ramasawmy, Iwan P. Williams, Bernard M. Siow, Mark F. Lythgoe, Tammy L. Kalber, Sergio A. Quezada, Martin A. Pule, Sonia Tugues, Karin Straathof, Burkhard Becher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Glioblastoma multiform (GBM) is a common and aggressive type of primary brain cancer that currently has no effective therapy. Here, the authors show, using a mouse GBM model and EGFRvIII-targeting chimeric antigen receptor (CAR)-T cells, that Intratu
Externí odkaz:
https://doaj.org/article/b2005a4f42464b199597399076f130a8
Autor:
Rebecca R. Baker, Christopher Payne, Yichao Yu, Matin Mohseni, John J. Connell, Fangyu Lin, Ian F. Harrison, Paul Southern, Umesh S. Rudrapatna, Daniel J. Stuckey, Tammy L. Kalber, Bernard Siow, Lewis Thorne, Shonit Punwani, Derek K. Jones, Mark Emberton, Quentin A. Pankhurst, Mark F. Lythgoe
Publikováno v:
Advanced Science, Vol 9, Iss 12, Pp n/a-n/a (2022)
Abstract Medical therapies achieve their control at expense to the patient in the form of a range of toxicities, which incur costs and diminish quality of life. Magnetic resonance navigation is an emergent technique that enables image‐guided remote
Externí odkaz:
https://doaj.org/article/4eba214398d34384888f82e6dd7bc048
Autor:
P. Stephen Patrick, Krishna K. Kolluri, May Zaw Thin, Adam Edwards, Elizabeth K. Sage, Tom Sanderson, Benjamin D. Weil, John C. Dickson, Mark F. Lythgoe, Mark Lowdell, Sam M. Janes, Tammy L. Kalber
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-12 (2020)
Abstract Background MSCTRAIL is a cell-based therapy consisting of human allogeneic umbilical cord-derived MSCs genetically modified to express the anti-cancer protein TRAIL. Though cell-based therapies are typically designed with a target tissue in
Externí odkaz:
https://doaj.org/article/77b713e5b32c4ca89d12cd9d999e858f
Autor:
Nephtali Marina, Isabel N. Christie, Alla Korsak, Maxim Doronin, Alexey Brazhe, Patrick S. Hosford, Jack A. Wells, Shahriar Sheikhbahaei, Ibrahim Humoud, Julian F. R. Paton, Mark F. Lythgoe, Alexey Semyanov, Sergey Kasparov, Alexander V. Gourine
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
The brain receives 20% of cardiac output, but in accord with the current knowledge lacks a specialized sensor of its own blood flow. Here, the authors show that brain astrocytes detect drops in perfusion and trigger compensatory increases in arterial
Externí odkaz:
https://doaj.org/article/460633936e6841f2ab72308399796298