Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Mark F, Lew"'
Autor:
Audrey A. Omidsalar, Carmel G. McCullough, Lili Xu, Stanley Boedijono, Daniel Gerke, Michelle G. Webb, Zarko Manojlovic, Adolfo Sequeira, Mark F. Lew, Marco Santorelli, Geidy E. Serrano, Thomas G. Beach, Agenor Limon, Marquis P. Vawter, Brooke E. Hjelm
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-20 (2024)
Abstract Common mitochondrial DNA (mtDNA) deletions are large structural variants in the mitochondrial genome that accumulate in metabolically active tissues with age and have been investigated in various diseases. We applied the Splice-Break2 pipeli
Externí odkaz:
https://doaj.org/article/b606b4bfef3147a49f38ed1db08b12ca
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 7, Iss , Pp 100161- (2022)
We discuss a shift in the treatment paradigm for OFF episode management in patients with Parkinson’s disease, based on clinical experience in the United States (US). Three “on-demand” treatments are currently available in the US as follows: sub
Externí odkaz:
https://doaj.org/article/105b3b7064584d5f9e1be363f134ee14
Autor:
Robert A. Hauser, Dean Sutherland, Juan A. Madrid, Maria Angeles Rol, Steven Frucht, Stuart Isaacson, Fernando Pagan, Brian N. Maddux, George Li, Winona Tse, Benjamin L. Walter, Rajeev Kumar, Daniel Kremens, Mark F. Lew, Aaron Ellenbogen, Odinachi Oguh, Alberto Vasquez, William Kinney, Matt Lowery, Maria Resnick, Nicole Huff, Jerry Posner, Karla V. Ballman, Brian E. Harvey, Michael Camilleri, Michael Zasloff, Denise Barbut
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 1, Iss , Pp 2-7 (2019)
Background: Parkinson's disease (PD) is associated with α-synuclein (αS) aggregation within the enteric nervous system (ENS) and constipation. Squalamine displaces proteins that are electrostatically bound to intracellular membranes and through thi
Externí odkaz:
https://doaj.org/article/4e17431a76c74ed5afd21868c7b59eeb
Autor:
Atul T Patel, Mark F Lew, Khashayar Dashtipour, Stuart Isaacson, Robert A Hauser, William Ondo, Pascal Maisonobe, Stefan Wietek, Bruce Rubin, Allison Brashear
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250475 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0245827.].
Externí odkaz:
https://doaj.org/article/678fa54813e44fa6aee14de2d0af6f97
Autor:
Atul T Patel, Mark F Lew, Khashayar Dashtipour, Stuart Isaacson, Robert A Hauser, William Ondo, Pascal Maisonobe, Stefan Wietek, Bruce Rubin, Allison Brashear
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0245827 (2021)
Cervical dystonia (CD) is primarily treated with botulinum toxin, at intervals of ≥ 12 weeks. We present efficacy, patient-reported outcomes (PROs), and safety in adults with CD at the last available visit after a single set of abobotulinumtoxinA (
Externí odkaz:
https://doaj.org/article/a5449450af90414086d5fdfeaf325785
Autor:
Mark F. Lew, Robert A. Hauser, Stuart H. Isaacson, Daniel Truong, Atul T. Patel, Allison Brashear, William Ondo, Pascal Maisonobe, Khashayar Dashtipour, Laxman Bahroo, Stefan Wietek
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 5, Iss , Pp 100115- (2021)
Introduction: Cervical dystonia (CD) is a neurologic movement disorder with potentially disabling effects and significant impact on quality of life of those affected. AbobotulinumtoxinA (aboBoNT-A) was initially approved for a dilution of 500 U/1 mL
Externí odkaz:
https://doaj.org/article/1b10f3346552463da42e87acfb171361
Autor:
Emily T. Tamadonfar, Mark F. Lew
Publikováno v:
Toxicon. 226:107087
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63ec5922d6b216f1b9139c4a2ae2eddc
https://doi.org/10.1016/j.toxicon.2023.107087
https://doi.org/10.1016/j.toxicon.2023.107087
Autor:
Mark F. Lew, Sarah F. Hamm-Alvarez, Srikanth Reddy Janga, Maria C. Edman, Danielle Feigenbaum, Wendy J. Mack, Daniel Freire, Curtis T. Okamoto
Publikováno v:
Biomarkers in Medicine. 13:1447-1457
Aim: Due to active engagement of sensory and afferent nerve fibers in reflex tearing which could be affected in Parkinson's disease (PD), we tested reflex tears as a source of potential PD biomarkers. Patients & methods: Reflex tears collected from 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d121ac1ce87a237b3e0233036fbab4a
https://doi.org/10.2217/bmm-2019-0315
https://doi.org/10.2217/bmm-2019-0315
Autor:
Srikanth Reddy Janga, Sarah F. Hamm-Alvarez, Raveena Ghanshani, Wendy J. Mack, Daniel Freire, Danielle Feigenbaum, Mark F. Lew, Maria C. Edman, Curtis T. Okamoto, Mihir Shah
Publikováno v:
Biomarkers in Medicine. 13:941-952
Aim: Secretion of proteins into basal tears of Parkinson’s disease (PD) patients may be altered by changes in nerve function. Materials & methods: Oligomeric α-SynOligo and total α-SynTotal, CCL-2, DJ-1, LF and MMP-9 were measured in basal tears
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a150065660aecf1ca236e2981c4e92f0
https://doi.org/10.2217/bmm-2019-0167
https://doi.org/10.2217/bmm-2019-0167
Autor:
Karla V. Ballman, Alberto Vasquez, Juan Antonio Madrid, Denise Barbut, Steven J. Frucht, Matt Lowery, Brian E. Harvey, Michael Zasloff, Maria Resnick, Mark F. Lew, William A. Kinney, Nicole Huff, Robert A. Hauser, Aaron Ellenbogen, Dean Sutherland, Maria Angeles Rol, Winona Tse, Odinachi Oguh, Rajeev Kumar, Brian N. Maddux, Daniel Kremens, Jerry Posner, Benjamin L. Walter, Michael Camilleri, Stuart Isaacson, George Li, Fernando Pagan
Publikováno v:
Clinical Parkinsonism & Related Disorders, Vol 1, Iss, Pp 2-7 (2019)
Clinical Parkinsonism & Related Disorders
Clinical Parkinsonism & Related Disorders
Background Parkinson's disease (PD) is associated with α-synuclein (αS) aggregation within the enteric nervous system (ENS) and constipation. Squalamine displaces proteins that are electrostatically bound to intracellular membranes and through this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb1ded24ddb745b86acdfc65f4256fa
http://www.sciencedirect.com/science/article/pii/S2590112519300015
http://www.sciencedirect.com/science/article/pii/S2590112519300015