Volumetric MRI-Based Biomarkers in Huntington's Disease: An Evidentiary Review

Autor: Kirsi M. Kinnunen, Adam J. Schwarz, Emily C. Turner, Dorian Pustina, Emily C. Gantman, Mark F. Gordon, Richard Joules, Ariana P. Mullin, Rachael I. Scahill, Nellie Georgiou-Karistianis, The Huntington's Disease Regulatory Science Consortium (HD-RSC), Varun Aggarwal, Shazia Ali, Irina Antonijevic, Astri Arnesen, Nazem Atassi, Brian Beers, Beth Belluscio, Limor Ben Har, Angele Benard, Caroline Benn, Brian Bettencourt, Anu Bhattacharyya, Robi Blumenstein, Beth Borowsky, Bret Bostwick, Jackson Burton, Angelika Caputo, David Cooper, Brad Elmer, Rebecca Evans, Andrew Feigen, Terrence Fisher, Rebecca Fuller, Emily Gantman, Danielle Gartner, Michal Geva, Sandra Gonzalez, Adam Good, Mark Gordon, Jaya Goyal, Michael Hayden, Priyantha Herath, Steve Hersch, Jianying Hu, Elise Kayson, Eileen Koski, Bernhard Landwehrmeyer, Michelle Lax, Blair Leavitt, Dorothy Leong, Oren Levy, Enchi Liu, Jeff Long, Doug Macdonald, Jacqueline Major, Lahar Mehta, Tiago Mestre, Eric Miller, Christian Mueller, Catherine O'Riordan, Jennifer Panagoulias, Mike Panzara, Anne Pedata, Jennifer Petrillo-Billet, Dave Podskalny, Alisha Reader, Shelly Redman, Ralf Reilmann, Klaus Romero, Christopher Ross, Anne Rosser, Cristina Sampaio, Jan Samzelius, Scott Schobel, Adam Schwarz, Sudhir Sivakumaran, Jennie Socha, Glenn Stebbins, Julie Stout, Sarah Tabrizi, Emily Turner, Charles Venuto, Louise Vetter, Vissia Viglietta, Sarah Wahlstrom Helgren, Beth White, Ed Wild, George Yohrling, Maurice Zauderer

Publikováno v: Frontiers in Neurology, Vol 12 (2021)

Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disorder that is caused by expansion of a CAG-repeat tract in the huntingtin gene and characterized by motor impairment, cognitive decline, and neuropsychiatric disturbanc

Externí odkaz: https://doaj.org/article/ca6c677056d045fbbeff255dc7be3a75

MRI predictors of amyloid pathology: results from the EMIF-AD Multimodal Biomarker Discovery study

Autor: Mara ten Kate, Alberto Redolfi, Enrico Peira, Isabelle Bos, Stephanie J. Vos, Rik Vandenberghe, Silvy Gabel, Jolien Schaeverbeke, Philip Scheltens, Olivier Blin, Jill C. Richardson, Regis Bordet, Anders Wallin, Carl Eckerstrom, José Luis Molinuevo, Sebastiaan Engelborghs, Christine Van Broeckhoven, Pablo Martinez-Lage, Julius Popp, Magdalini Tsolaki, Frans R. J. Verhey, Alison L. Baird, Cristina Legido-Quigley, Lars Bertram, Valerija Dobricic, Henrik Zetterberg, Simon Lovestone, Johannes Streffer, Silvia Bianchetti, Gerald P. Novak, Jerome Revillard, Mark F. Gordon, Zhiyong Xie, Viktor Wottschel, Giovanni Frisoni, Pieter Jelle Visser, Frederik Barkhof

Publikováno v: Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-12 (2018)

Abstract Background With the shift of research focus towards the pre-dementia stage of Alzheimer’s disease (AD), there is an urgent need for reliable, non-invasive biomarkers to predict amyloid pathology. The aim of this study was to assess whether

Externí odkaz: https://doaj.org/article/adb96ce37d3740419818576a0bb69a24

Importance and hurdles to drug discovery for neurological disease

Autor: Joseph R, Berger, Dennis, Choi, Henry J, Kaminski, Mark F, Gordon, Orest, Hurko, O'Neill, D'Cruz, Samuel J, Pleasure, Eva L, Feldman

Publikováno v: Annals of neurology. 74(3)

This is a critical time in neurotherapeutics. The prevalence of neurological disease, such as dementia, stroke, and peripheral neuropathy, is large and growing consequent to the aging population. The personal and societal impact of these disorders is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5ee6476378b9e3725c3496e6437088a
https://pubmed.ncbi.nlm.nih.gov/25813523

Lrrk2 and Lewy body disease.

Autor: Owen A. Ross, Mathias Toft, Andrew J. Whittle, Joseph L. Johnson, Spiridon Papapetropoulos, Deborah C. Mash, Irene Litvan, Mark F. Gordon, Zbigniew K. Wszolek, Matthew J. Farrer, Dennis W. Dickson

Publikováno v: Annals of Neurology; Feb2006, Vol. 59 Issue 2, p388-393, 6p

Two modes of amber codon read-through in vitro

Autor: Akira Kaji, Masaru Ryoji, T. Yamane, Mark F. Gordon

Publikováno v: Archives of biochemistry and biophysics. 238(2)

Read-through translation of bacteriophage R17 amB2 coat cistron carrying an amber mutation at the seventh codon was studied in vitro using the crude cell extract (S30) derived from an Escherichia coli nonsuppressor strain. Despite the presence of ter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe58605d5dd25ce89c8cf42a6ab1d9e
https://pubmed.ncbi.nlm.nih.gov/3888114