Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mark Enstrom"'
Autor:
Stefan Radtke, Dnyanada Pande, Margaret Cui, Anai M. Perez, Yan-Yi Chan, Mark Enstrom, Stefanie Schmuck, Andrew Berger, Tom Eunson, Jennifer E. Adair, Hans-Peter Kiem
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 679-691 (2020)
Hematopoietic stem cell (HSC) gene therapy has the potential to cure many genetic, malignant, and infectious diseases. We have shown in a nonhuman primate gene therapy and transplantation model that the CD34+CD90+ cell fraction was exclusively respon
Externí odkaz:
https://doaj.org/article/261752fffa134004b8b8adfca84f2e43
Publikováno v:
mBio, Vol 3, Iss 2 (2012)
ABSTRACT To help define the biological functions of nonessential genes of Francisella novicida, we measured the growth of arrayed members of a comprehensive transposon mutant library under a variety of nutrition and stress conditions. Mutant phenotyp
Externí odkaz:
https://doaj.org/article/ccf55f3555474e7d86cf56ddf7f620ea
Autor:
Sowmya Reddy, Stefan Radtke, Hans-Peter Kiem, Christopher W. Peterson, Dnyanada Pande, Olivier Humbert, Mark Enstrom, Rasika Venkataraman
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss, Pp 30-39 (2022)
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss, Pp 30-39 (2022)
Over the past decade, numerous gene-editing platforms which alter host DNA in a highly specific and targeted fashion have been described. Two notable examples are zinc finger nucleases (ZFNs), the first gene-editing platform to be tested in clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77639224ab2d8f75358a36a661fa7695
http://europepmc.org/articles/PMC8671732
http://europepmc.org/articles/PMC8671732
Autor:
Stefan Radtke, Yogendra S. Rajawat, Dnyanada Pande, Hans-Peter Kiem, Savannah Cook, Martin E. Wohlfahrt, Mark Enstrom, Olivier Humbert
Publikováno v:
Hum Gene Ther
Hematopoietic stem and progenitor cell (HSPC)-based ex vivo gene therapy has demonstrated clinical success for X-linked severe combined immunodeficiency (SCID-X1) patients who lack a suitable donor for HSPC transplantation. Nevertheless, this form of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7003eba98936ed444d1db32b9ef88c
https://doi.org/10.1089/hum.2020.127
https://doi.org/10.1089/hum.2020.127
Autor:
Stefan Radtke, Mark Enstrom, Dnyanada Pande, Ravishankar Madhu, Staci Owen, Greta Kanestrom, Margaret Cui, Anai M Perez, Hans-Peter Kiem
Publikováno v:
Blood. 140:5719-5720
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a07faaf8929f4f19ba15397400406a4d
https://doi.org/10.1182/blood-2022-158535
https://doi.org/10.1182/blood-2022-158535
Autor:
Margaret Cui, Andrew Berger, Stefanie Schmuck, Jennifer E. Adair, Anai M. Perez, Yan-Yi Chan, Tom Eunson, Hans-Peter Kiem, Stefan Radtke, Dnyanada Pande, Mark Enstrom
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 679-691 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 679-691 (2020)
Hematopoietic stem cell (HSC) gene therapy has the potential to cure many genetic, malignant, and infectious diseases. We have shown in a nonhuman primate gene therapy and transplantation model that the CD34+CD90+ cell fraction was exclusively respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920b21f02a657c920794b84136a0fa70
http://europepmc.org/articles/PMC7424231
http://europepmc.org/articles/PMC7424231
Autor:
Mark Enstrom, Ravishankar Madhu, Stefan Radtke, Hans-Peter Kiem, Anai M. Perez, Margaret Cui, Dnyanada Pande
Reconstitution after hematopoietic stem cell (HSC) transplantation is assumed to occur in two distinct phases: initial recovery mediated by short-term progenitors and long-term repopulation by multipotent HSCs which do not contribute to hematopoietic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::962c6845b5571f8dc98cce5590d30e52
https://doi.org/10.1101/2021.09.21.461235
https://doi.org/10.1101/2021.09.21.461235
Autor:
Mark Enstrom, Katherine E. Brandenstein, Hans-Peter Kiem, Meei-Li Huang, Gavin I. Ellis, James L. Riley, Christine M. Fennessey, Blake J. Rust, Keith R. Jerome, Willimark M. Obenza, Christopher W. Peterson, Colby R. Maldini, Brandon F. Keele, Leslie S. Kean, Lucrezia Colonna, Nikhita Hegde Poole
Publikováno v:
Blood
Chimeric antigen receptor (CAR) T cells targeting CD19+ hematologic malignancies have rapidly emerged as a promising, novel therapy. In contrast, results from the few CAR T-cell studies for infectious diseases such as HIV-1 have been less convincing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fb90641ea04beff90b90a4e0ce5dd8
https://europepmc.org/articles/PMC7544543/
https://europepmc.org/articles/PMC7544543/
Autor:
Kevin G. Haworth, Lauren E Schefter, Matthew H. Porteus, Shaina Porter, Daniel Humphrys, Mark Enstrom, Kenric Tam, Reza Shahbazi, Hans-Peter Kiem, Jennifer E. Adair
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 796-809 (2020)
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 796-809 (2020)
In vivo tracking of retrovirus-tagged blood stem and progenitor cells is used to study hematopoiesis. Two techniques are used most frequently: sequencing the locus of retrovirus insertion, termed integration site analysis, or retrovirus DNA barcode s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c961cadd9510c8b4542517c43f1034e
https://pubmed.ncbi.nlm.nih.gov/32355868
https://pubmed.ncbi.nlm.nih.gov/32355868
Autor:
Laila-Aicha Hanafi, Stanley R. Riddell, Martin E. Wohlfahrt, Peter S. Linsley, Raphael Gottardo, Mark Enstrom, David G. Maloney, Valentin Voillet, Dnyanada Pande, Masanao Yajima, Hannah A. DeBerg, Hans-Peter Kiem, Vivian H. Gersuk, Jennifer E. Adair, Alyssa Sheih, Reed M. Hawkins, Cameron J. Turtle
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Chimeric antigen receptor (CAR) T-cell therapy has produced remarkable anti-tumor responses in patients with B-cell malignancies. However, clonal kinetics and transcriptional programs that regulate the fate of CAR-T cells after infusion remain poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00ab25f6fcbbe42b00bb7f021f539fa
https://doi.org/10.1038/s41467-019-13880-1
https://doi.org/10.1038/s41467-019-13880-1