Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mark Embrey"'
Autor:
Jay A. Grobler, Abbas Walji, Paul J. Coleman, Min Xu, Timothy J. Hartingh, Natasa Pajkovic, John T. Sisko, David A. Powell, John M. Sanders, Michael D. Miller, Mark Embrey, Rada Vanessa L, Keith P. Moore, Daniel J. Klein, Nguyen Natalie, Izzat T. Raheem, Dubost David C, Guillaume Barbe, Louis-Charles Campeau, Daria J. Hazuda, John S. Wai, Thomas G. Steele, John D. Schreier, Jamie M. McCabe Dunn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2038-2046
HIV integrase strand transfer inhibitors (InSTIs) represent an important class of antiviral therapeutics with proven efficacy and excellent tolerability for the treatment of HIV infections. In 2007, Raltegravir became the first marketed strand transf
Autor:
Joseph P. Vacca, Linghang Zhuang, Lori J. Gabryelski, Terry A. Lyle, William A. Schleif, Peter J. Felock, Boyoung Kim, Lixia Jin, I.-W. Chen, Donnette D. Staas, Chris Culberson, Steven D. Young, Daria J. Hazuda, Thorsten E. Fisher, John S. Wai, Peter D. Williams, Mark Embrey, Rama Mallai, Joan D. Ellis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5595-5599
A series of potent novel dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors was identified. These compounds inhibited the strand transfer process of HIV-1 integrase and viral replication in cells. Compound 6 is active against replication of
Autor:
Gregory Moyer, Linghang Zhuang, Lori J. Gabryelski, Marc V. Witmer, Lixia Jin, Jiunn H. Lin, William A. Schleif, Yvonne M. Leonard, Peter J. Felock, Mark Embrey, Nancy N. Tsou, Kara A. Stillmock, Joseph P. Vacca, Debbie S. Perlow, Steven D. Young, Bradley K. Wong, Carl F. Homnick, Timothy W. Funk, John S. Wai, Joan D. Ellis, Daria J. Hazuda, I.-W. Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4550-4554
Introduction of a 5,6-dihydrouracil functionality in the 5-position of N -(4-fluorobenzyl)-8-hydroxy-[1,6]naphthyridine-7-carboxamide 1 led to a series of highly active HIV-1 integrase inhibitors. These compounds displayed low nanomolar activity in i
Autor:
Melissa S. Egbertson, Marc V. Witmer, Linghang Zhuang, James P. Guare, William A. Schleif, Abigail Wolfe, Payne Linda S, Peter J. Felock, Stuart R. Michelson, Daria J. Hazuda, Steven D. Young, John S. Wai, Joseph J. Lynch, Kara A. Stillmock, Joseph P. Vacca, Lori J. Gabryelski, Yvonne M. Leonard, Mark Embrey, Thorsten E. Fisher, Gregory Moyer
Publikováno v:
Journal of Medicinal Chemistry. 46:453-456
Naphthyridine 7 inhibits the strand transfer of the integration process catalyzed by integrase with an IC50 of 10 nM and inhibits 95% of the spread of HIV-1 infection in cell culture at 0.39 microM. It does not exhibit cytotoxicity in cell culture at
Autor:
Cathryn A. Shaw-Reid, James L. Cole, John S. Wai, Mark Embrey, Vandna Munshi, Marc V. Witmer, David B. Olsen, Abigail Wolfe, Daria J. Hazuda, Michael D. Miller, Steven S. Carroll, Pia L. Graham, Renee Danzeisen
Publikováno v:
Journal of Biological Chemistry. 278:2777-2780
Human immunodeficiency virus-type 1 (HIV-1) reverse transcriptase (RT) coordinates DNA polymerization and ribonuclease H (RNase H) activities using two discrete active sites embedded within a single heterodimeric polyprotein. We have identified a nov
Publikováno v:
Synthetic Communications. 26:3431-3442
Two complementary routes for the preparation of 3-alkyl-6-bromo-4,5-E-hexenoate are reported.
Publikováno v:
Tetrahedron Letters. 36:3461-3464
An efficient synthetic sequence was developed for the preparation of γ-alkylated E-olefin isosteres of dipeptides.
Autor:
Izzat T. Raheem, Abbas M. Walji, Daniel Klein, John M. Sanders, David A. Powell, Pravien Abeywickrema, Guillaume Barbe, Amrith Bennet, Karla Childers, Melodie Christensen, Sophie−Dorothee Clas, David Dubost, Mark Embrey, Jay Grobler, Michael J. Hafey, Timothy J. Hartingh, Daria J. Hazuda, Jeffrey T. Kuethe, Jamie McCabe Dunn, Michael D. Miller, Keith P. Moore, Andrew Nolting, Natasa Pajkovic, Sangita Patel, Zuihui Peng, Vanessa Rada, Paul Rearden, John D. Schreier, John Sisko, Thomas G. Steele, Jean-François Truchon, John Wai, Min Xu, Paul J. Coleman
Publikováno v:
Journal of Medicinal Chemistry. 59:486-486
Publikováno v:
ChemInform. 26
An efficient synthetic sequence was developed for the preparation of γ-alkylated E-olefin isosteres of dipeptides.
Publikováno v:
ChemInform. 27
Two complementary routes for the preparation of 3-alkyl-6-bromo-4,5-E-hexenoate are reported.