Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Mark Egerton"'
Publikováno v:
The Journal of Cell Biology
Rad, Gem/Kir, and mRem (RGK) represent a unique GTPase family with largely unknown functions (Reynet, C., and C.R. Kahn. 1993. Science. 262:1441–1444; Cohen, L., R. Mohr, Y. Chen, M. Huang, R. Kato, D. Dorin, F. Tamanoi, A. Goga, D. Afar, N. Rosenb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1d0f304188eaa16b903ac09a552d77
http://europepmc.org/articles/PMC2174817
http://europepmc.org/articles/PMC2174817
Publikováno v:
International Immunology. 10:223-229
The extracellular signal-regulated kinase (ERK) signaling pathway is strongly activated in response to TCR stimulation in normal T cells. However, the extent to which activation of the ERK pathway is necessary for TCR-stimulated cytokine production i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47a2ef9d6ee3d761b037d74281e70cb
https://doi.org/10.1093/intimm/10.2.223
https://doi.org/10.1093/intimm/10.2.223
Autor:
Stanley Falkow, Alistair J. P. Brown, Neil A. R. Gow, Brendan P. Cormack, Mark Egerton, Gwyneth Bertram
Publikováno v:
Microbiology. 143:303-311
The green fluorescent protein (GFP) of Aequorea victoria has been developed here as a reporter for gene expression and protein localization in Candida albicans. When wild-type (wt) GFP was expressed in C. albicans, it was not possible to detect fluor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadbd1d5c9f0bf63b76f0ecbf0adb1f3
https://doi.org/10.1099/00221287-143-2-303
https://doi.org/10.1099/00221287-143-2-303
Publikováno v:
Biochemical and Biophysical Research Communications. 224:666-674
T cell antigen receptor (TCR) ligation results in the tyrosine phosphorylation of numerous intracellular protein substrates, and the identification of these substrates has been a major undertaking by several groups. We have used pervanadate treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df0e91d22dbf95c38c19b7d15c6b6c6
https://doi.org/10.1006/bbrc.1996.1082
https://doi.org/10.1006/bbrc.1996.1082
Publikováno v:
The Journal of Cell Biology
Scopus-Elsevier
Scopus-Elsevier
Anchoring of proteins to membranes by glycosylphosphatidylinositols (GPIs) is ubiquitous among all eukaryotes and heavily used by parasitic protozoa. GPI is synthesized and transferred en bloc to form GPI-anchored proteins. The key enzyme in this pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9ce3f48a17d7b3ca849400bbaa0d20
http://europepmc.org/articles/PMC2120449
http://europepmc.org/articles/PMC2120449
Autor:
Lawrence E. Samelson, Mark Egerton
Publikováno v:
Journal of Biological Chemistry. 269:11435-11441
Engagement of the T cell antigen receptor (TCR) leads to activation of multiple tyrosine kinases and rapid tyrosine phosphorylation of intracellular protein substrates. A number of these substrates have been identified and they include TCR subunits,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78369b654f44f324ae9c839de6057446
https://doi.org/10.1016/s0021-9258(19)78142-3
https://doi.org/10.1016/s0021-9258(19)78142-3
Publikováno v:
Yeast. 9:703-713
Strains of Saccharomyces cerevisiae harbouring temperature-sensitive mutations in the SEC1 and SEC5 genes exhibit an accumulation of post-Golgi secretory vesicles at 37 degrees C. We have cloned a fragment of yeast DNA which carries two distinct gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34e1cc4be3982b47da300606ae323ae
https://doi.org/10.1002/yea.320090704
https://doi.org/10.1002/yea.320090704
Autor:
Ezio Bonvini, Andrew F. Phillips, Pam Thomas, George A. Sarosi, Lawrence E. Samelson, Kyu Won Kim, Mark Egerton
Publikováno v:
International Immunology. 4:1211-1217
Engagement of the TCR by specific antigen results in activation of a tyrosine kinase pathway. A candidate for the kinase responsible for the rapid tyrosine phosphorylation detected with T cell activation is p60fyn, a member of the src kinase family.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b348fb82b373ee78368a9bd0b0cb6c7a
https://doi.org/10.1093/intimm/4.11.1211
https://doi.org/10.1093/intimm/4.11.1211
Publikováno v:
The Journal of Experimental Medicine
Cortical thymocytes from adult mice, separated on the basis of coexpression of CD4 and CD8 or of binding of high levels of peanut agglutinin (PNA), were subdivided according to the level of expression of the T cell receptor (TCR)-CD3 complex. The inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8d07caccb3dc88006c5137c806152d
https://doi.org/10.1084/jem.173.2.323
https://doi.org/10.1084/jem.173.2.323
Publikováno v:
Proceedings of the National Academy of Sciences. 87:2579-2582
We have reexamined the balance between cell birth, cell maturation, and cell death in the thymus by labeling dividing thymocytes and their progeny in vivo with [3H]-thymidine, isolating clearly defined subpopulations by fluorescence-activated cell so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d93a4c219d96edd9cec557cf350c0a32
https://doi.org/10.1073/pnas.87.7.2579
https://doi.org/10.1073/pnas.87.7.2579