Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mark Edward Ruppen"'
Autor:
Mark Edward Ruppen, Ping Cai, Viliam Pavliak, Justin Keith Moran, Nancy Khoury, Olivier Marcq, Chenghua Deng
Publikováno v:
Carbohydrate Research. 351:98-107
The original structure of Streptococcus pneumoniae capsular polysaccharide (CPS) serotype 6C was proposed based on chemical degradation and tandem mass analysis [J. Clin. Microbiol.2007, 45, 1225-1233]. In order to confirm the repeat unit structure a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f33b99231a898219606de79057d520
https://doi.org/10.1016/j.carres.2012.01.017
https://doi.org/10.1016/j.carres.2012.01.017
Publikováno v:
The Journal of Antibiotics. 63:693-698
Treatment of a variety of tetracyclines (tigecycline, minocycline, tetracycline and doxycycline) with Ag(2)CO(3)/EDTA or Hg(OAc)(2) cleanly gave the 4,11a-bridged derivatives in high yields. The reactions proceeded through a novel, intramolecular Man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aca0d76bee3e9f93efcdb6b30c9b9b3
https://doi.org/10.1038/ja.2010.119
https://doi.org/10.1038/ja.2010.119
Autor:
Li Di, Arie Zask, Mark Edward Ruppen, Judy Lucas, Mairead Young, Jianyao Wang, Michael Cinque, Inder Chaudhary, Christine Gaydos, Semiramis Ayral-Kaloustian, Tarek S. Mansour, Ker Yu, Jianxin Gu, James Joseph Gibbons
Publikováno v:
Journal of Medicinal Chemistry. 53:452-459
Hyperactivation of the PI3K/AKT/mTOR signaling pathway is common in cancer, and PI3K and mTOR act synergistically in promoting tumor growth, survival, and resistance to chemotherapy. Thus, combined targeting of PI3K and mTOR presents an opportunity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3caec72437ce666d53433e05dcfda997
https://doi.org/10.1021/jm901427g
https://doi.org/10.1021/jm901427g
Publikováno v:
Organic Letters. 7:3945-3948
A lipase-catalyzed acylation of the immunosuppressant rapamycin with complete regioselectivity is described. The method was successfully applied to the synthesis of 42-hemiesters and temsirolimus (CCI-779), an investigational oncology drug.[reaction:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced9268025e4c88bc285d908443437dc
https://doi.org/10.1021/ol0514395
https://doi.org/10.1021/ol0514395
Autor:
Alan G. Sutherland, Russell Dushin, Ming Liu, Ping Cai, Jason Arnold Lotvin, Mark Edward Ruppen, Arthur R. Bailey
Publikováno v:
Tetrahedron: Asymmetry. 15:2821-2824
α-Mannosidase catalyzes the removal of the O -linked mannose units from mannopeptimycin-α. The reaction can be run on a preparative scale to allow isolation of mannopeptimycin-β or the mono- O -mannosyl intermediate according to the choice of cata
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49d3a8247439ba858ce2a36a1a04e91c
https://doi.org/10.1016/j.tetasy.2004.07.056
https://doi.org/10.1016/j.tetasy.2004.07.056
Publikováno v:
ChemInform. 42
The reaction of minocycline (I) with mercuric acetate proceeds with oxidation of a dimethylamino group followed by a novel intramolecular Mannich cyclization of an intermediate iminium cation leading to 4,11a-bridged derivative (II) in high yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b28e723ac05e559320a0e62ec4bac75d
https://doi.org/10.1002/chin.201117193
https://doi.org/10.1002/chin.201117193
Autor:
James Joseph Gibbons, Ping Cai, Parimal Desai, Jianxin Gu, Inder Chaudhary, Ker Yu, Judy Lucas, Arie Zask, Tianmin Zhu, Jerauld S. Skotnicki, Mark Edward Ruppen, Tarek S. Mansour, Fawzi Mahdi, Yumin Gong, Fangbiao Li, Russ Tsao, Semiramis Ayral-Kaloustian
Publikováno v:
Journal of medicinal chemistry. 49(4)
Phosphoinositide 3-kinase (PI3K) is an important target for cancer chemotherapy due to the deregulation of its signaling pathway in a wide spectrum of human tumors. Wortmannin and its analogues are potent PI3K inhibitors whose therapeutic use has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1e57e3852aabf366bbcf6c83a3ad75
https://pubmed.ncbi.nlm.nih.gov/16480272
https://pubmed.ncbi.nlm.nih.gov/16480272