Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mark E. Zupec"'
Autor:
Deborah E. Whipple, Mark E. Zupec, Steven Paul Adams, Derek S. Towery, Foe S. Tjoeng, Kam F. Fok, Mark H. Williams, Joseph W. Bulock
Publikováno v:
International Journal of Peptide and Protein Research. 35:141-146
An automated multiple peptide synthesis method to synthesize, cleave, and purify several peptides simultaneously in a single batch has been developed. The technique is based on the synthesis of multiple peptides on a single solid phase support and is
Autor:
Suzanne Metz, Mahima Trivedi, William M. Moore, Timothy J. Hagen, Mark E. Zupec, Jane R. Connor, Mark G. Currie, B. S. Pitzele, Kam F. Fok, M. V. Toth, Pamela T. Manning, Ronald Keith Webber, D. W. Hansen, Gina M. Jerome, F. S. Tjoeng
Publikováno v:
Journal of Medicinal Chemistry. 41:96-101
A series of analogues of 2-iminopiperidine have been prepared and shown to be potent inhibitors of the human nitric oxide synthase (NOS) isoforms. Methyl substitutions on the 4-position (3) or 4- and 6-positions (8) afforded the most potent analogues
Autor:
Hwang-Fun Lu, James A. Sikorski, Sandra K. Freeman, David L. Brown, Mark E. Zupec, Srinivasan Nagarajan, Getman Daniel P, Balekudru Devadas, Charles A. McWherter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:379-382
A survey of potential cyclic and acyclic lysine replacements in known l -seryl- l -lysyl dipeptide inhibitors of C. albicans NMT identified the thioether 16 and glycinamide 18 as submicromolar inhibitors of C. albicans NMT, which retained good select
Autor:
Jeffrey I. Gordon, James A. Sikorski, Daniel P. Getman, Nandini S. Kishore, Balekudru Devadas, Martin L. Bryant, Mark E. Zupec, Srinivasan Nagarajan, Mcwherter Charles A, Pramod P. Mehta, Arlene C. Wade, David L. Brown, Sandra K. Freeman, Hwang-Fun Lu
Publikováno v:
Biopolymers. 43:43-71
MyristoylCoA: protein N-myristoyltransferase (NMT) catalyzes the cotranslational covalent attachment of a rare cellular fatty acid, myristate, to the N-terminal Gly residue of a variety of eukaryotic proteins. The myristoyl moiety is often essential
Autor:
James A. Sikorski, David L. Brown, Srinivasan Nagarajan, Sandra K. Freeman, Jeffrey I. Gordon, Mark E. Zupec, Balekudru Devadas, Getman Daniel P, Mcwherter Charles A
Publikováno v:
Journal of Medicinal Chemistry. 38:1837-1840
Autor:
Dudley E. McMackins, Mihaly V. Toth, Henry E. Dayringer, J. G. Rico, P. R. Bovy, Nancy S. Nicholson, Anita K. Salyers, Beatrice B. Taite, Jeffery Alan Zablocki, Larry P. Feigen, Thomas E. Rogers, Shashidhar N. Rao, Mark E. Zupec, Robert Bruce Garland, Steven Paul Adams, M. Herin, R. J. Lindmark, Foe S. Tjoeng, S.G. Panzer-Knodle, Masateru Miyano
Publikováno v:
Bioorganic & Medicinal Chemistry. 2:881-895
The evolutionary process from the Arg-Gly-Asp-Phe (RGDF) tetrapeptide to potent orally active anti-platelet agents is presented. The RGD sequence is an important component in the recognition of fibrinogen by its platelet receptor GP IIb-IIIa (integri
Autor:
Larry A. Kaempfe, M.F. McGrath, John C. Byatt, Billy D. Vineyard, Jacob S. Tou, Bernie N. Violand, Mark E. Zupec
Publikováno v:
Biochemical and Biophysical Research Communications. 167:484-491
Bovine transforming growth factor-alpha (bTGF-alpha) is a 50 amino acid polypeptide with three disulfide linkages. In order to evaluate the biological function of this peptide, bTGF-alpha was synthesized via an automatic synthesizer and purified to h
Autor:
Dipa Patel, Daniel S. Pereira, Larry Witte, Karen Gustafson, Xavier Delannay, Rajiv Bassi, Floyd Fox, Jacob S. Tou, Peter Bohlen, Yuemei Ma, Michael Barry, Xenia Jimenez, Paul Kussie, Douglas Burtrum, Douglas A. Russell, John McIntyre, William L. Petersen, Fernando Gaitan-Gaitan, Xiaoqiang Kang, S. Joseph Tarnowski, Daniel J. Hicklin, Qinwei Zhou, Dale L. Ludwig, Daniel L. Moran, Babita Saxena, Zhenping Zhu, Mark E. Zupec, Bradley S. Storrs, Marie Prewett, Thomas P. Jury
Publikováno v:
Human antibodies. 13(3)
Recombinant protein production in plants such as corn is a promising means to generate high product yields at low comparable production cost. The anti-EGFR monoclonal antibody C225, cetuximab, is a well-characterized receptor antagonist antibody rece
Autor:
Dutt V. Vinjamoori, David W. Kuneman, Srinivasan R. Nagarajan, James A. Sikorski, Jennifer K. Lodge, Balekudru Devadas, Mcwherter Charles A, Hwang Fun Lu, Daniel P. Getman, Jeffrey I. Gordon, Mark E. Zupec, Sandra K. Freeman, Nandini S. Kishore
Publikováno v:
Journal of medicinal chemistry. 40(16)
A new class of antifungal agents has been discovered which exert their activity by blockade of myristoylCoA: protein N-myristoyltransferase (NMT; EC 2.1.3.97). Genetic experiments have established that NMT is needed to maintain the viability of Candi
Autor:
Mcwherter Charles A, Jeffrey I. Gordon, Daniel P. Getman, Srinivasan Nagarajan, Hwang-Fun Lu, Balekudru Devadas, Nandini S. Kishore, Pramod P. Mehta, James A. Sikorski, Mark E. Zupec, Sandra K. Freeman, David L. Brown
Publikováno v:
Journal of medicinal chemistry. 40(10)
MyristoylCoA:protein N-myristoyltransferase (NMT) covalently attaches the 14-carbon saturated fatty acid myristate, via an amide bond, to the N-terminal glycine residues of a variety of cellular proteins. Genetic studies have shown that NMT is essent