Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mark E. Tometsko"'
Autor:
William C. Fanslow, Kim C. Quon, Matthew M. Bio, Margaret F. Weidner, Wesley S. Chang, Jason W. O'Neill, Christopher J. Borths, Dan A. Rock, Seamus P. Ragan, Sophia Siu, Robert R. Milburn, Sonal K. Patel, Brooke M. Rock, Mark E. Tometsko, Jesse L. Gurgel, Allison P. Jacob, Kevin J. Hamblett
Genes identified as critical for CD70 ADC function in Library 1 screen (S1); Genes identified as critical for CD70 ADC function in Library 2 screen (S2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afd7b980e59ed2ae74732dbadbd5224
https://doi.org/10.1158/0008-5472.22406852
https://doi.org/10.1158/0008-5472.22406852
Autor:
William C. Fanslow, Kim C. Quon, Matthew M. Bio, Margaret F. Weidner, Wesley S. Chang, Jason W. O'Neill, Christopher J. Borths, Dan A. Rock, Seamus P. Ragan, Sophia Siu, Robert R. Milburn, Sonal K. Patel, Brooke M. Rock, Mark E. Tometsko, Jesse L. Gurgel, Allison P. Jacob, Kevin J. Hamblett
Predicted topology for SLC46A3 (S1); Effect of siRNA on mRNA expression of SLC46A3 and CD70 in 786-0 cells (S2); Effect of siRNA on CD70 protein expression in 786-0 cells (S3); Anti-CD70 Ab-DSG-Maytansine and anti-CD70 Ab-Cys-Maytansine are potent ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eff3eb212c549f79dc7834903550168
https://doi.org/10.1158/0008-5472.22406858.v1
https://doi.org/10.1158/0008-5472.22406858.v1
Autor:
William C. Fanslow, Kim C. Quon, Matthew M. Bio, Margaret F. Weidner, Wesley S. Chang, Jason W. O'Neill, Christopher J. Borths, Dan A. Rock, Seamus P. Ragan, Sophia Siu, Robert R. Milburn, Sonal K. Patel, Brooke M. Rock, Mark E. Tometsko, Jesse L. Gurgel, Allison P. Jacob, Kevin J. Hamblett
Description of additional methods and procedures used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33716785c78c5ac8ae1ee739e76fa395
https://doi.org/10.1158/0008-5472.22406855.v1
https://doi.org/10.1158/0008-5472.22406855.v1
Autor:
Allison P. Jacob, Christopher J. Borths, Matthew M. Bio, Sophia Siu, Mark E. Tometsko, Kevin J. Hamblett, Jason W. O'Neill, Jesse L. Gurgel, Seamus Ragan, Margaret F. Weidner, William C. Fanslow, Brooke M. Rock, Wesley Chang, Kim Quon, Robert R. Milburn, Dan A. Rock, Sonal K. Patel
Publikováno v:
Cancer Research. 75:5329-5340
Antibody–drug conjugates (ADC) target cytotoxic drugs to antigen-positive cells for treating cancer. After internalization, ADCs with noncleavable linkers are catabolized to amino acid-linker-warheads within the lysosome, which then enter the cytop
Autor:
Daniel Branstetter, Kathy Rohrbach, William C. Dougall, Li-Ya Huang, R Soriano, Allison P. Jacob, Michelle Blake, Mark E. Tometsko
Publikováno v:
Journal of Bone Oncology, Vol 4, Iss 3, Pp 59-68 (2015)
Journal of Bone Oncology
Journal of Bone Oncology
Receptor activator of nuclear factor kappa-B ligand (RANKL) is an essential mediator of osteoclast formation, function and survival. In patients with solid tumor metastasis to the bone, targeting the bone microenvironment by inhibition of RANKL using
Autor:
Brooke M. Rock, Kip P. Conner, Jason W. O'Neill, Mark E. Tometsko, Tiep Le, Kevin J. Hamblett, Justin N. Huard, Robert R. Milburn, Dan A. Rock, Sophia Siu, William C. Fanslow
Publikováno v:
Molecular pharmaceutics. 13(7)
Antibody-drug conjugates (ADC) rely on the target-binding specificity of an antibody to selectively deliver potent drugs to cancer cells. IgG antibody half-life is regulated by neonatal Fc receptor (FcRn) binding. Histidine 435 of human IgG was mutat
Autor:
Francesc Viñals, William C. Dougall, Eva González-Suárez, Ander Urruticoechea, D Branstetter, Maria Teresa Soler, Pasquale Pellegrini, Purificación Muñoz, Sergi Vila, Mark E. Tometsko, Marta Palafox, Fina Climent, Irene Ferrer, Sara Hernández-Ortega
Publikováno v:
Cancer Research. 72:2879-2888
Paracrine signaling through receptor activator of NF-κB (RANK) pathway mediates the expansion of mammary epithelia that occurs during pregnancy, and activation of RANK pathway promotes mammary tumorigenesis in mice. In this study we extend these pre
Autor:
Sonal K. Patel, Dan A. Rock, Kevin J. Hamblett, Brooke M. Rock, Mark E. Tometsko, William C. Fanslow
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 43(9)
Antibody drug conjugates are emerging as a powerful class of antitumor agents with efficacy across a range of cancers; therefore, understanding the disposition of this class of therapeutic is crucial. Reported here is a method of enriching a specific
Autor:
Kiyoshi Takeda, Jonathan M.J. Derry, Shizuo Akira, Mark E. Tometsko, William C. Dougall, Michelle Chaisson, Allison P. Armstrong, Daniel Branstetter
Publikováno v:
Journal of Biological Chemistry. 279:54841-54848
Signaling through the receptor activator of nuclear factor kappa B (RANK) is required for both osteoclast differentiation and mammary gland development, yet the extent to which RANK utilizes similar signaling pathways in these tissues remains unclear
Autor:
David Cosman, Claire L. Sutherland, Allison P. Armstrong, Moira Glaccum, William C. Dougall, Mark E. Tometsko
Publikováno v:
Journal of Biological Chemistry. 277:44347-44356
Signaling through receptor activator of nuclear factor-kappaB (RANK) is essential for the differentiation and activation of osteoclasts, the cell principally responsible for bone resorption. Animals genetically deficient in RANK or the cognate RANK l