Cost-effectiveness of Universal and Targeted Hepatitis C Virus Screening in the United States

Autor: Susana Keeshin, Fernando A. Wilson, Mark E. Mailliard, Moosa Tatar

Publikováno v: JAMA Network Open

Key Points Question Are universal hepatitis C virus (HCV) screening for all US adults aged 18 years or older and targeted HCV screening among people who inject drugs cost-effective for limiting HCV infection? Findings In this economic evaluation stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594d1ebe902b7c6b8ddb4e4009517766
http://europepmc.org/articles/PMC7489814

Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: Effects on protein-l-isoaspartyl methyltransferase activity

Autor: Cheryl R. Baldwin, Mark E. Mailliard, Dean J. Tuma, Michael F. Sorrell, Kusum K. Kharbanda

Publikováno v: Journal of Hepatology. 46:1119-1125

Background/Aims Protein-l-isoaspartyl methyltransferase (PIMT) is a methyltransferase that plays a crucial role in the repair of damaged proteins. In this study, we investigated whether ethanol exposure causes an accumulation of modified proteins bea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e461bb876ddf9792789d2fdc5f43d1
https://doi.org/10.1016/j.jhep.2007.01.026

Effectiveness of Simeprevir Plus Sofosbuvir, With or Without Ribavirin, in Real-World Patients With HCV Genotype 1 Infection

Autor: P. Pockros, Ira M. Jacobson, A. M. Di Bisceglie, Gregory T. Everson, Mark E. Mailliard, J.R. Spivey, H.E. Vargas, Thomas G. Stewart, C.A. Kerr, K.R. Reddy, H.A. Elbeshbeshy, Gyongyi Szabo, M.S. Sulkowski, Norah A. Terrault, Nezam H. Afdhal, P. Kwo, K. Rajender Reddy, T.N. Hawkins, Coleman Smith, Eugene R. Schiff, J. Lim, I.M. Jacobson, G. Morelli, Michael W. Fried, Lynn M. Frazier, Andrew J. Muir, Mohamed Hassan, Jordan J. Feld, Giuseppe Morelli, Federico Hinestrosa, Hugo E. Vargas, Mitchell L. Shiffman, Richard K. Sterling, Adrian M. Di Bisceglie, Imtiaz Alam, Nancy Reau, Ziv Ben-Ari, Mark S. Sulkowski, A. Williams, R.T. Chung, J. Darling, C. Trautwein, Josh Levitsky, Stefan Zeuzem, Jonathan M. Fenkel, J. Bredfeldt, Rolland C. Dickson, Kenneth E. Sherman, Ananthakrishnan Ramani, R.S. Brown, Jama M. Darling, M.W. Fried, A. Kuo, David R. Nelson, Joseph S. Galati, Jacqueline G. O'Leary, W. Harlan, D. Nelson, Joseph K. Lim, A.S. Lok, Michael P. Manns, Alexander Kuo, Robert S. Brown, Brian L. Pearlman, K. Watts, S.C. Gordon

Publikováno v: Gastroenterology. 150(2)

Background & Aims The interferon-free regimen of simeprevir plus sofosbuvir was recommended by professional guidelines for certain patients with hepatitis C virus (HCV) genotype 1 infection based on the findings of a phase 2 trial. We aimed to evalua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0386631f32a4d6005c94cae77bb5183
https://pubmed.ncbi.nlm.nih.gov/26497081

A Comparison of the Effects of Betaine and S-Adenosylmethionine on Ethanol-Induced Changes in Methionine Metabolism and Steatosis in Rat Hepatocytes

Autor: David D. Rogers, Gerri L. Siford, Mark E Mailliard, Dean J. Tuma, Anthony J. Barak, Kusum K. Kharbanda, Harriet C. Beckenhauer, Michael F. Sorrell

Publikováno v: The Journal of Nutrition. 135:519-524

Previous studies showed that chronic ethanol administration alters methionine metabolism in the liver, resulting in increased intracellular S-adenosylhomocysteine (SAH) levels and increased homocysteine release into the plasma. We showed further that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b75df6c6b72dc5bdea2c81ed82c09c1
https://doi.org/10.1093/jn/135.3.519

Cholestasis of sepsis

Autor: Mark E Mailliard, John L Gollan, Richard K Gilroy

Publikováno v: Best Practice & Research Clinical Gastroenterology. 17:357-367

Cholestasis of sepsis is a form of hepatocellular cholestasis that occurs as a result of sepsis. Usually, prior to the development of cholestasis, the manifestations of sepsis dominate the clinical picture. The occurrence of cholestasis is without di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4b45a532cc2e13ff576a85f7b21727c
https://doi.org/10.1016/s1521-6918(03)00027-1