Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Mark E. Kleinman"'
Publikováno v:
Data in Brief, Vol 32, Iss , Pp 106076- (2020)
Juvenile neuronal ceroid lipofuscinosis (JNCL, aka. juvenile Batten disease or CLN3 disease), a lethal pediatric neurodegenerative disease without cure, often presents with vision impairment and characteristic ophthalmoscopic features including focal
Externí odkaz:
https://doaj.org/article/a75a940506794613b66eca791fc9fb5e
Autor:
Bradley D. Gelfand, Charles B. Wright, Younghee Kim, Tetsuhiro Yasuma, Reo Yasuma, Shengjian Li, Benjamin J. Fowler, Ana Bastos-Carvalho, Nagaraj Kerur, Annette Uittenbogaard, Youn Seon Han, Dingyuan Lou, Mark E. Kleinman, W. Hayes McDonald, Gabriel Núñez, Philippe Georgel, Joshua L. Dunaief, Jayakrishna Ambati
Publikováno v:
Cell Reports, Vol 11, Iss 11, Pp 1686-1693 (2015)
Excess iron induces tissue damage and is implicated in age-related macular degeneration (AMD). Iron toxicity is widely attributed to hydroxyl radical formation through Fenton’s reaction. We report that excess iron, but not other Fenton catalytic me
Externí odkaz:
https://doaj.org/article/978a1cd998d14ea7902ee02655f15e7f
Autor:
Patricia A. D'Amore, Anders M. Näär, kahira Saez-Torres, Gopalan Gnanaguru, Alexandre Wagschal, Ryan E. Temel, Mark E. Kleinman, Tong Li, Justin Oh
Publikováno v:
Mol Ther
Abnormal cholesterol/lipid homeostasis is linked to neurodegenerative conditions such as age-related macular degeneration (AMD), which is a leading cause of blindness in the elderly. The most prevalent form, termed "dry" AMD, is characterized by path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658eade241a6d6e6e1bbb16ae6656816
https://europepmc.org/articles/PMC8261163/
https://europepmc.org/articles/PMC8261163/
Publikováno v:
Data in Brief
Data in Brief, Vol 32, Iss, Pp 106076-(2020)
Data in Brief, Vol 32, Iss, Pp 106076-(2020)
Juvenile neuronal ceroid lipofuscinosis (JNCL, aka. juvenile Batten disease or CLN3 disease), a lethal pediatric neurodegenerative disease without cure, often presents with vision impairment and characteristic ophthalmoscopic features including focal
Autor:
Ahmad Al-Attar, Hunter N. B. Moseley, Jinpeng Liu, Shuyan Lu, Qing Jun Wang, Mark E. Kleinman, Huijuan Liu, Yu Zhong, Penghui Lin, Mihail I. Mitov, Nianwei Lin, Jinze Liu, D. Allan Butterfield, Rahul Deshpande, Qiushi Sun, Teresa W.-M. Fan, Robert M. Flight, Marc O. Warmoes, Kyung Jung, Kabhilan Mohan
Publikováno v:
Biochim Biophys Acta Mol Basis Dis
Juvenile neuronal ceroid lipofuscinosis (JNCL, aka. juvenile Batten disease or CLN3 disease) is a lysosomal storage disease characterized by progressive blindness, seizures, cognitive and motor failures, and premature death. JNCL is caused by mutatio
Publikováno v:
Annals of the New York Academy of Sciences. 1371:55-67
Juvenile neuronal ceroid lipofuscinosis (JNCL; also known as CLN3 disease) is a devastating neurodegenerative lysosomal storage disorder and the most common form of Batten disease. Progressive visual and neurological symptoms lead to mortality in pat
Autor:
Jayakrishna Ambati, Mark E. Kleinman
The posterior segment of the eye is a complex assembly of specialized structures derived from neuroectoderm and mesenchyme. A dual-layered blood-retina barrier serves to protect this vital cellular circuitry that integrates visual data while the unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::751dfe24226bef6fa207a38cb381948e
https://doi.org/10.1016/b978-0-12-809324-5.01407-3
https://doi.org/10.1016/b978-0-12-809324-5.01407-3
Autor:
Mark E. Kleinman, Charles B. Wright, Younghee Kim, Bradley D. Gelfand, Nagaraj Kerur, Shengjian Li, Philippe Georgel, Ana Bastos-Carvalho, Youn Seon Han, Dingyuan Lou, Joshua L. Dunaief, W. Hayes McDonald, Tetsuhiro Yasuma, Annette Uittenbogaard, Benjamin J. Fowler, Gabriel Núñez, Jayakrishna Ambati, Reo Yasuma
Publikováno v:
Cell Reports, Vol 11, Iss 11, Pp 1686-1693 (2015)
Excess iron induces tissue damage and is implicated in age-related macular degeneration (AMD). Iron toxicity is widely attributed to hydroxyl radical formation through Fenton's reaction. We report that excess iron, but not other Fenton catalytic meta
Autor:
Paul A. Frederick, Mark E. Kleinman
Publikováno v:
Current Ophthalmology Reports. 2:14-19
Age related macular degeneration (AMD) is a complex, multifactorial disease that has yet to be completely understood. Significant efforts in the basic and clinical sciences have unveiled numerous areas which appear to be critical in the pathogenesis
Publikováno v:
Annals of the New York Academy of Sciences. 1371(1)
Juvenile neuronal ceroid lipofuscinosis (JNCL; also known as CLN3 disease) is a devastating neurodegenerative lysosomal storage disorder and the most common form of Batten disease. Progressive visual and neurological symptoms lead to mortality in pat