Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Mark E. Hayes"'
Autor:
Dmitri B. Kirpotin, Mark E. Hayes, Charles O. Noble, Zhaohua Richard Huang, Kshitija Wani, Doug Moore, Kevin Kesper, Drew O’ Brien, Daryl C. Drummond
Publikováno v:
Journal of Pharmaceutical Sciences. 112:416-434
Therapeutics at or close to the nanoscale, such as liposomal irinotecan, offer significant promise for the treatment of solid tumors. Their potential advantage over the unencapsulated or free form of the drug is due in part to their altered biodistri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bd9f760d124dc003eb2aa686d5244c
https://doi.org/10.1016/j.xphs.2022.11.025
https://doi.org/10.1016/j.xphs.2022.11.025
Publikováno v:
Blood. 140:11557-11558
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b23686365a13fe25568c4ba78721103
https://doi.org/10.1182/blood-2022-168103
https://doi.org/10.1182/blood-2022-168103
Autor:
Allen Ebens, Pui Yan Ho, Maire Rayburn, Mark E Hayes, Scott W. Leonard, James M. Coull, Tumul Srivastava, Somayeh S. Tarighat, Zhen Zhang, Xiao-Jun Li, Agnieszka Czechowicz, Carla Dib, Sze Nok Tam, Andrew Curd, Lan Wang, Mark J. Fiandaca, Marshall Fordyce, Brandon Hriniak, Derek S. Sim
Publikováno v:
Proc Natl Acad Sci U S A
Triplex gene editing relies on binding a stable peptide nucleic acid (PNA) sequence to a chromosomal target, which alters the helical structure of DNA to stimulate site-specific recombination with a single-strand DNA (ssDNA) donor template and elicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d46e966f3f19eb7c7aa2ec80090f8a
https://pubmed.ncbi.nlm.nih.gov/34732575
https://pubmed.ncbi.nlm.nih.gov/34732575
Autor:
Lia Luus, Vasileios Askoxylakis, John Wilton, Alexey Lugovskoy, Kenneth J. Olivier, Stephanie Grabow, Jaeyeon Kim, Christine Pien, Geoffrey Kuesters, Suresh K. Tipparaju, Melissa Geddie, Nancy Dumont, Mark E. Hayes, Alexander Koshkaryev, Sarah A Schihl, C. Patrick Reynolds, Rachel Blaydes, Andrew J. Sawyer, James D. Marks, Tad Kornaga, James Suchy, Charles O. Noble, Dmitri B. Kirpotin, Shinji Oyama, Neeraj Kohli, Zhaohua Richard Huang, Walid S. Kamoun, Daryl C. Drummond, Yu Zhou
Publikováno v:
Nature Biomedical Engineering. 3:264-280
Antibody-mediated tumour targeting and nanoparticle-mediated encapsulation can reduce the toxicity of antitumour drugs and improve their efficacy. Here, we describe the performance of a nanotherapeutic encapsulating a hydrolytically sensitive docetax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8e94f819de7e7f6ccdf49b01d0fee2
https://doi.org/10.1038/s41551-019-0385-4
https://doi.org/10.1038/s41551-019-0385-4
Autor:
Ran Ming, Nan Zheng, Charles O. Noble, Zhipeng Dai, Yayuan Liu, Wenmin Yuan, Anna Schwendeman, Jie Tang, Wenlei Jiang, Santhanakrishnan Srinivasan, Francis C. Szoka, Mark E. Hayes
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 134
AmBisome® is a liposomal formulation of amphotericin B (Amp B), a complex parenteral antifungal product with no US FDA approved generic version available to date. For generic Amp B liposomal product development, examination of the drug release profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300778ffcb3b43748ad215e56e27fb1b
https://pubmed.ncbi.nlm.nih.gov/30481559
https://pubmed.ncbi.nlm.nih.gov/30481559
Autor:
Byron Hann, Ceirin Connolly-Ingram, Bianca S. Gabriel, Keelung Hong, Daryl C. Drummond, Christopher C. Benz, John W. Park, Zexiong Guo, Dmitri B. Kirpotin, Mark E. Hayes, Bin Liu, Charles O. Noble, James D. Marks
Publikováno v:
Journal of Controlled Release. 141:13-21
Topotecan (TPT), a highly active anticancer camptothecin drug, would benefit from nanocarrier-mediated site-specific and intracellular delivery because of a labile lactone ring whose hydrolysis inactivates the drug, poor cellular uptake resulting fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd86429326aa02082522d8e6920fe11
https://doi.org/10.1016/j.jconrel.2009.08.006
https://doi.org/10.1016/j.jconrel.2009.08.006
Autor:
John W. Park, Charles O. Noble, Keelung Hong, Mark E. Hayes, Yun Long Tseng, Dmitri B. Kirpotin, Ching-Ju Ou, Zexiong Guo, Daryl C. Drummond
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:321-330
Effective liposomal formulations of vinorelbine (5′ nor-anhydro-vinblastine; VRL) have been elusive due to vinorelbine's hydrophobic structure and resulting difficulty in stabilizing the drug inside the nanocarrier. Triethylammonium salts of severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830f2c31351275cf1ad100563edd6f3d
https://doi.org/10.1124/jpet.108.141200
https://doi.org/10.1124/jpet.108.141200
Autor:
Wenmin Yuan, Anna Schwendeman, Rui Kuai, Wenlei Jiang, Yue Yuan, Zhipeng Dai, Francis C. Szoka, Nan Zheng, Charles O. Noble, Mark E. Hayes
Publikováno v:
The AAPS journal. 19(1)
Doxil® is a complex parenteral doxorubicin (DOX) liposome formulation approved by the FDA. For generic doxorubicin liposomes, analyzing the release profile of DOX is important for quality control and comparability studies. However, there is no robus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aeb07af0a827cccca122487211179f9
https://pubmed.ncbi.nlm.nih.gov/27485642
https://pubmed.ncbi.nlm.nih.gov/27485642
Autor:
Christopher C. Benz, Charles O. Noble, Keelung Hong, Christoph Mamot, Daryl C. Drummond, Mark E. Hayes, Dmitri B. Kirpotin, John W. Park, James D. Marks
Publikováno v:
Expert Opinion on Therapeutic Targets. 8:335-353
The continued evolution of targeted liposomal therapeutics has resulted in new agents with remarkable antitumour efficacy and relatively mild toxicity profiles. A careful selection of the ligand is necessary to reduce immunogenicity, retain extended
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86df1ddc9e48382272c9ecac5df98fae
https://doi.org/10.1517/14728222.8.4.335
https://doi.org/10.1517/14728222.8.4.335
Autor:
John Forsayeth, Daryl C. Drummond, Piotr Hadaczek, Mitchel S. Berger, Janine Beyer, Mark E. Hayes, Krystof S. Bankiewicz, Charles O. Noble, Michal T. Krauze, John W. Park, Dmitri B. Kirpotin
Publikováno v:
Nanomedicine (London, England). 9(14)
Aim: We sought to evaluate nanoliposomal irinotecan as an intravenous treatment in an orthotopic brain tumor model. Materials & methods: Nanoliposomal irinotecan was administered intravenously in the intracranial U87MG brain tumor model in mice, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116e4c661688fabfba8ada7920d5db94
https://pubmed.ncbi.nlm.nih.gov/24494810
https://pubmed.ncbi.nlm.nih.gov/24494810