Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mark E. Fife"'
Autor:
Mark E. Fife, Marnix R. Jonker, Elizabeth K. Marsh, Shao Cong Sun, Clare F. Muir, Lynne Williams, J. Kelley Bentley, Wim Timens, Ian Sabroe, Irene H. Heijink, Ben S. Barksby, Helen M. Marriott, James P. Stewart, Marc B. Hershenson, David H. Dockrell, Tracy Hussell, Amber R. Hart, Elizabeth C. Prestwich, Lee A. Borthwick, Lisa C. Parker
Publikováno v:
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Frontiers in Cellular and Infection Microbiology, 10:456. Frontiers Media SA
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Frontiers in Cellular and Infection Microbiology, 10:456. Frontiers Media SA
Exposure to respiratory pathogens is a leading cause of exacerbations of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Pellino-1 is an E3 ubiquitin ligase known to regulate virally-induced inflammation. We wished to
Autor:
Nicolas, Dutzan, Loreto, Abusleme, Hayley, Bridgeman, Teresa, Greenwell-Wild, Tamsin, Zangerle-Murray, Mark E, Fife, Nicolas, Bouladoux, Holly, Linley, Laurie, Brenchley, Kelly, Wemyss, Gloria, Calderon, Bo-Young, Hong, Timothy J, Break, Dawn M E, Bowdish, Michail S, Lionakis, Simon A, Jones, Giorgio, Trinchieri, Patricia I, Diaz, Yasmine, Belkaid, Joanne E, Konkel, Niki M, Moutsopoulos
Publikováno v:
Immunity. 46(1):133-147
Immuno-surveillance networks operating at barrier sites are tuned by local tissue cues to ensure effective immunity. Site-specific commensal bacteria provide key signals ensuring host defense in the skin and gut. However, how the oral microbiome and
Autor:
Lisa C. Parker, Ian Sabroe, Irene H. Heijink, A. R. Hart, Lynne Williams, J. K. Bentley, Wim Timens, Shao Cong Sun, Lee A. Borthwick, Clare F. Muir, Ben S. Barksby, Helen M. Marriott, James P. Stewart, Mark E. Fife, Tracy Hussell, Marnix R. Jonker, Elizabeth K. Marsh, Marc B. Hershenson, David H. Dockrell, Elizabeth C. Prestwich
Publikováno v:
The influence of influenza: from cells to humans.
Introduction and objectives Exposure to respiratory pathogens is a leading cause of exacerbations of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). We have shown that Pellino-1, an E3 ubiquitin ligase, is involved in
Autor:
Stephen J. Fowler, G Tavernier, Andrew S. MacDonald, Robert Niven, Peter C. Cook, Angela Simpson, Björn Dahlbäck, Toshifumi Fujimori, Emma Connolly, Kaisa E. Happonen, Rajesh Shah, Aleksander M. Grabiec, Nicholas Denny, Mark E. Fife, John A. Doherty, Jenny Hankinson, Susan Holden, Tracy Hussell, Naoya Fujino, Anu Goenka
Publikováno v:
Grabiec, A M, Denny, N, Doherty, J, Happonen, K E, Hankinson, J, Connolly, E, Fife, M E, Fujimori, T, Fujino, N, Goenka, A, Holden, S, Gioan-Tavernier, G, Shah, R, Cook, P, MacDonald, A, Niven, R, Dahlbäck, B, Fowler, S, Simpson, A & Hussell, T 2017, ' Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma. ', Journal of Allergy and Clinical Immunology, vol. 140, no. 4, pp. 1144-1146 . https://doi.org/10.1016/j.jaci.2017.03.024
The apoptotic cell recognition receptor Axl is highly expressed on human airway/alveolar macrophages, its expression is driven by the lung microenvironment and is significantly reduced in asthma, which may explain defects in apoptotic cell clearance
Autor:
Aleksander M. Grabiec, Gudrun Weiss, Robert J. Snelgrove, Tracy Hussell, Cheryl Lai, Clare M. Lloyd, Gang Xin, Bernadett Tildy, Mark E. Fife
Publikováno v:
Weiss, G, Lai, C, E Fife, M, M Grabiec, A, Tildy, B, Snelgrove, R J, Xin, G, M Lloyd, C & Hussell, T 2016, ' Reversal of TREM-1 ectodomain shedding and improved bacterial clearance by intranasal metalloproteinase inhibitors ', Mucosal Immunology . https://doi.org/10.1038/mi.2016.104
Triggering receptor expressed on myeloid cells-1 (TREM-1) is expressed on neutrophils and monocyte/macrophages and amplifies Toll-like receptor (TLR)-mediated inflammation during infection. TREM-1 also exists in an antagonistic soluble form (sTREM-1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f18aae3cbd93d3a350c1ea4c25e7ab
https://doi.org/10.1038/mi.2016.104
https://doi.org/10.1038/mi.2016.104
Autor:
Nicolas Dutzan, Loreto Abusleme, Hayley Bridgeman, Teresa Greenwell-Wild, Tamsin Zangerle-Murray, Mark E Fife, Nicolas Bouladoux, Holly Linley, Laurie Brenchley, Kelly Wemyss, Giorgio Trinchieri, Patricia I Diaz, Yasmine Belkaid, Joanne E Konkel, Niki M Moutsopoulos
Publikováno v:
The Journal of Immunology. 198:71.1-71.1
At barrier sites, resident immune cell populations help to maintain tissue homeostasis and function. These cells receive and integrate key signals from the local environment including stromal/epithelial cells and the commensal microbiome. Studies of