Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Mark E. Curran"'
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-10 (2017)
Abstract Background An individual patient’s response to a particular drug is influenced by multiple factors, which may include genetic predisposition. Pharmacogenetic studies attempt to discover and estimate the contributions of genetic variants to
Externí odkaz:
https://doaj.org/article/fee6f2188d2343a2b2ae080d83f9c2dd
Autor:
D. Wang, Gayle M. Wittenberg, Justine M. Kent, Jaskaran Singh, Benjamin Hsu, Jessica Vermeulen, Yu Sun, Corey Casper, Mark E. Curran, Wayne C. Drevets, Guang Chen, Giacomo Salvadore
Publikováno v:
Brain, Behavior, and Immunity. 66:156-164
Cytokines, including interleukin-6 (IL-6), modulate neuronal plasticity and stress coping. Depressive symptoms and major depressive disorder (MDD) have been associated with changes in cytokines and their signaling. The current study examined the effe
Autor:
Yongzhong Zhao, Mark E. Curran, Hardik Shah, Mary Beth Humphrey, Jeremiah J. Faith, Eunjee Lee, Arthur Mortha, Lauren A. Peters, Bojan Losic, Anuk Das, Brian A. Kidd, Eric M. Neiman, Sean R. Llewellyn, Radu Dobrin, Panos Roussos, Riccardo Miotto, Teresa K. Tarrant, Joshua R. Friedman, Antonio Fabio Di Narzo, Khader Shameer, Won-Min Song, Jun Zhu, Bin Zhang, Carmen Argmann, Eric E. Schadt, Alina Iuga, Carrie Brodmerkel, Jacqueline Perrigoue, Lloyd Mayer, Andrew Kasarskis, Yoshinori Fukui, Aleksandar Stojmirović, Jocelyn Sendecki, Brian M. Iritani, Shannon Telesco, Minghui Wang, Nicholas E.S. Sibinga, Ke Hao
Publikováno v:
Nature genetics
A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data sets to construct predictive models of IBD. We present a predictive model of the immune component of IBD that informs causal relationships among loci previou
Autor:
Suso Platero, Mark E Curran
Publikováno v:
Pharmacogenomics. 12:465-470
On 1–2 December 2010 worldwide leaders in the field of co-diagnostics gathered in Boston, MA, USA, to discuss the state of predictive medicine and the complexities of biomarker implementation and partnering. Flanking the primary conference were thr
Autor:
Aritz Irizar, Wenhui Wang, Lauren A. Peters, Won-Min Song, Jean-Frederic Colombel, Marla Dubinsky, Carrie Brodmerkel, Carmen Argmann, Ryan C. Ungaro, Jun Zhu, Ashish Atreja, Scott E. Plevy, Eric E. Schadt, Mark E. Curran, Milind Mahajan, Mayte Suárez-Fariñas, Roman Kosoy, Jason Rogers, Radu Dobrin, Bojan Losic, Anabella Castillo, Bruce E. Sands, Jacqueline Perrigoue, Joshua R. Friedman, Gabrielle Wei, Ke Hao, Aleksandar Stojmirović, Andrew Kasarskis, Amanda Hurley, Antonio Fabio Di Narzo, Ruiqi Huang, Bin Zhang
Publikováno v:
Gastroenterology. 154:S-1024
Autor:
Monica Chadha, Igor Splawski, Richard S. Judson, David J. Tester, J. Claiborne Stephens, Michael J. Ackerman, Melissa L. Will, Mark T. Keating, Gregg S. Jones, Mark E. Curran, Jonathan C. Makielski, Christopher R. Burrow, Chuanbo Xu, Katherine W. Timothy
Publikováno v:
Heart Rhythm. 1:600-607
Objectives The purpose of this study was to determine the prevalence and spectrum of nonsynonymous polymorphisms (amino acid variants) in the cardiac sodium channel among healthy subjects. Background Pathogenic mutations in the cardiac sodium channel
Autor:
Fumiyuki Fukui, Brian A. Kidd, Antonio Fabio Di Narzo, Won-Min Song, Alina Iuga, Panos Roussos, Eric M. Neiman, Bojan Losic, Anuk Das, Teresa K. Tarrant, Joel T. Dudley, Radu Dobrin, Jun Zhu, Jeremiah J. Faith, Sean R. Llewellyn, Eric E. Schadt, Carmen Argmann, Bin Zhang, Ariella Cohain, Riccardo Miotto, Yongzhong Zhao, Khader Shameer, Hardik Shah, Arthur Mortha, Lauren A. Peters, Mark E. Curran, Lloyd Mayer, Jacqueline Perrigoue, Andrew Kasarskis, Nicholas E.S. Sibinga, Miriam Merad, Aleksandar Stojmirović, Brian M. Iritani, Ke Hao, Joshua R. Friedman
Publikováno v:
Gastroenterology. 150:S571-S572
Autor:
Christopher R. Burrow, Melissa L. Will, Gregg S. Jones, Michael J. Ackerman, David J. Tester, Mark E. Curran
Publikováno v:
Mayo Clinic Proceedings. 78:1479-1487
Objective To determine the spectrum, frequency, and ethnic-specificity of channel variants in the potassium channel genes implicated in congenital long QT syndrome (LQTS) among healthy subjects. Subjects and Methods Genomic DNA from 744 apparently he
Autor:
John E. Lennard-Jones, Stefan Schreiber, Christopher G. Mathew, A Macpherson, Jochen Hampe, Mark E. Curran, Cathryn M. Lewis, Sheila A. Fisher, Alastair Forbes
Publikováno v:
European Journal of Human Genetics. 10:259-265
Inflammatory bowel disease (IBD) is a multifactorial disorder, with both genetic and environmental factors contributing to the two clinical phenotypes of Crohn's disease (CD) and ulcerative colitis (UC). The underlying genetic model is thought to inv
Autor:
John E. Lennard-Jones, Stefan Schreiber, Christopher G. Mathew, Nicolas J. Lynch, Stephen Bridger, Jochen Hampe, Andrew J. Macpherson, Pieter C. F. Stokkers, Mark E. Curran, Susan Daniels, Alastair Forbes
Publikováno v:
Gut, 48(2), 191-197. BMJ Publishing Group
BACKGROUND AND AIMS—Genetic predisposition for inflammatory bowel disease (IBD) has been demonstrated by epidemiological and genetic linkage studies. Genetic linkage of IBD to chromosome 3 has been observed previously. A high density analysis of ch