Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Mark E Warchol"'
Autor:
Melanie Holmgren, Michael E Ravicz, Kenneth E Hancock, Olga Strelkova, Dorina Kallogjeri, Artur A Indzhykulian, Mark E Warchol, Lavinia Sheets
Publikováno v:
eLife, Vol 10 (2021)
Excess noise damages sensory hair cells, resulting in loss of synaptic connections with auditory nerves and, in some cases, hair-cell death. The cellular mechanisms underlying mechanically induced hair-cell damage and subsequent repair are not comple
Externí odkaz:
https://doaj.org/article/054f1334e50d48d3b96da9188ffa6f0f
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2015)
The sensory organs of the inner ear possess resident populations of macrophages, but the function of those cells is poorly understood. In many tissues, macrophages participate in the removal of cellular debris after injury and can also promote tissue
Externí odkaz:
https://doaj.org/article/51797c7cd2f041b691cfad9a7a3eda16
Publikováno v:
eLife, Vol 4 (2015)
The sensory and supporting cells (SCs) of the organ of Corti are derived from a limited number of progenitors. The mechanisms that regulate the number of sensory progenitors are not known. Here, we show that Fibroblast Growth Factors (FGF) 9 and 20,
Externí odkaz:
https://doaj.org/article/d4c0042d621740a997a5886c9f20ec99
Publikováno v:
PLoS Biology, Vol 10, Iss 1, p e1001231 (2012)
A large proportion of age-related hearing loss is caused by loss or damage to outer hair cells in the organ of Corti. The organ of Corti is the mechanosensory transducing apparatus in the inner ear and is composed of inner hair cells, outer hair cell
Externí odkaz:
https://doaj.org/article/05c6f96fba2a4967810d271fe66c8b9e
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51574 (2012)
Macrophages are the primary effector cells of the innate immune system and are also activated in response to tissue injury. The avian cochlea contains a population of resident macrophages, but the precise function of those cells is not known. The pre
Externí odkaz:
https://doaj.org/article/67587e679f5143499f9330da91c27185
Autor:
R David Hawkins, Stavros Bashiardes, Kara E Powder, Samin A Sajan, Veena Bhonagiri, David M Alvarado, Judith Speck, Mark E Warchol, Michael Lovett
Publikováno v:
PLoS ONE, Vol 2, Iss 6, p e525 (2007)
Loss of inner ear sensory hair cells (HC) is a leading cause of human hearing loss and balance disorders. Unlike mammals, many lower vertebrates can regenerate these cells. We used cross-species microarrays to examine this process in the avian inner
Externí odkaz:
https://doaj.org/article/c6f39d60eac74b3883722a932ff59fec
Autor:
Vijayprakash Manickam, Dinesh Y. Gawande, Andrew R. Stothert, Anna C. Clayman, Lyudmila Batalkina, Mark E. Warchol, Kevin K. Ohlemiller, Tejbeer Kaur
Publikováno v:
The Journal of Neuroscience. 43:2075-2089
Resident cochlear macrophages rapidly migrate into the inner hair cell synaptic region and directly contact the damaged synaptic connections after noise-induced synaptopathy. Eventually, such damaged synapses are spontaneously repaired, but the preci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7637c0960dfa0a14455bd651bc2dd9c5
https://doi.org/10.1523/jneurosci.1273-22.2023
https://doi.org/10.1523/jneurosci.1273-22.2023
Autor:
Mark E. Warchol, Jennifer S. Stone
Publikováno v:
Hair Cell Regeneration ISBN: 9783031206603
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffd9e57b50fe524f692d312d5e2098d2
https://doi.org/10.1007/978-3-031-20661-0_1
https://doi.org/10.1007/978-3-031-20661-0_1
Autor:
Steven H. Green, Sepand Bafti, Benjamin M. Gansemer, A. Eliot Shearer, Muhammad Taifur Rahman, Mark E. Warchol, Marlan R. Hansen
Publikováno v:
Hair Cell Regeneration ISBN: 9783031206603
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c17099f84dc74e7cff9ee3fad970279d
https://doi.org/10.1007/978-3-031-20661-0_7
https://doi.org/10.1007/978-3-031-20661-0_7
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 14302
Cisplatin is an effective anticancer agent, but also causes permanent hearing loss by damaging hair cells—the sensory receptors essential for hearing. There is an urgent clinical need to protect cochlear hair cells in patients undergoing cisplatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e43e7b515da7b503cef131015af338
https://pubmed.ncbi.nlm.nih.gov/36430778
https://pubmed.ncbi.nlm.nih.gov/36430778