Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Mark E Polinkovsky"'
Autor:
James W. P. Brown, Arnaud Bauer, Mark E Polinkovsky, Akshay Bhumkar, Dominic J. B. Hunter, Katharina Gaus, Emma Sierecki, Yann Gambin
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
Single-molecule in vitro assays require dedicated confocal microscopes equipped with fluorescence correlation spectroscopy (FCS) modules. Here the authors present a compact, cheap and open-source 3D-printed confocal microscope for single photon count
Externí odkaz:
https://doaj.org/article/9dbd763de888423491044a480dfdd1b9
Autor:
Kerrie-Ann McMahon, David A Stroud, Yann Gambin, Vikas Tillu, Michele Bastiani, Emma Sierecki, Mark E Polinkovsky, Thomas E Hall, Guillermo A Gomez, Yeping Wu, Marie-Odile Parat, Nick Martel, Harriet P Lo, Kum Kum Khanna, Kirill Alexandrov, Roger Daly, Alpha Yap, Michael T Ryan, Robert G Parton
Publikováno v:
eLife, Vol 10 (2021)
Caveolae-associated protein 3 (cavin3) is inactivated in most cancers. We characterized how cavin3 affects the cellular proteome using genome-edited cells together with label-free quantitative proteomics. These studies revealed a prominent role for c
Externí odkaz:
https://doaj.org/article/ec3b060033e84fb68b9e5ab9f7821ac0
Autor:
Yann Gambin, Nicholas Ariotti, Kerrie-Ann McMahon, Michele Bastiani, Emma Sierecki, Oleksiy Kovtun, Mark E Polinkovsky, Astrid Magenau, WooRam Jung, Satomi Okano, Yong Zhou, Natalya Leneva, Sergey Mureev, Wayne Johnston, Katharina Gaus, John F Hancock, Brett M Collins, Kirill Alexandrov, Robert G Parton
Publikováno v:
eLife, Vol 3 (2014)
In mammalian cells three closely related cavin proteins cooperate with the scaffolding protein caveolin to form membrane invaginations known as caveolae. Here we have developed a novel single-molecule fluorescence approach to directly observe interac
Externí odkaz:
https://doaj.org/article/3222892030ff4bd78593681b9cee2d10
Autor:
Nick Martel, Harriet P. Lo, Mark E. Polinkovsky, Yann Gambin, Kirill Alexandrov, Robert G. Parton, Roger J. Daly, Kerrie-Ann McMahon, Michele Bastiani, Thomas E. Hall, Michael T. Ryan, Vikas A. Tillu, Guillermo A. Gomez, Kum Kum Khanna, Emma Sierecki, David A. Stroud, Marie-Odile Parat, Yeping Wu, Alpha S. Yap
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Caveolae-associated protein 3 (cavin3) is inactivated in most cancers. We characterized how cavin3 affects the cellular proteome using genome-edited cells together with label-free quantitative proteomics. These studies revealed a prominent role for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97672dc3a117bb49f6e2519d301cbb74
https://elifesciences.org/articles/61407
https://elifesciences.org/articles/61407
Autor:
Nick Martel, Vikas A. Tillu, Emma Sierecki, Thomas E. Hall, Alpha S. Yap, Kirill Alexandrov, Yeping Wu, Kum Kum Khanna, Roger J. Daly, David A. Stroud, Marie-Odile Parat, Mark E. Polinkovsky, Michele Bastiani, Guillermo A. Gomez, Robert G. Parton, Harriet P. Lo, Michael T. Ryan, Kerrie-Ann McMahon, Yann Gambin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a094586228557d839dc3f7149a2cf2d
https://doi.org/10.7554/elife.61407.sa2
https://doi.org/10.7554/elife.61407.sa2
Autor:
Roger J. Daly, Michael T. Ryan, Mark E. Polinkovsky, Vikas A. Tillu, Yann Gambin, Guillermo A. Gomez, Thomas E. Hall, Kerrie-Ann McMahon, Kirill Alexandrov, Robert G. Parton, Harriet P. Lo, David A. Stroud, Marie-Odile Parat, Alpha S. Yap, Emma Sierecki, Kum Kum Khanna, Nick Martel, Yeping Wu, Michele Bastiani
Caveolae-associated protein 3 (cavin3), a putative tumor suppressor protein, is inactivated in most cancers. We characterized how cavin3 affects the cellular proteome using genome-edited cells together with label-free quantitative proteomics. These s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9abadced3d3966cbbbc57c170806a44
https://doi.org/10.1101/2020.07.26.222158
https://doi.org/10.1101/2020.07.26.222158
Autor:
Emma Sierecki, Yann Gambin, Nichole Giles, Dominic J. B. Hunter, Mark E. Polinkovsky, Ailis O'Carroll
Publikováno v:
Journal of molecular biology. 430(4)
Single-molecule fluorescence has the unique ability to quantify small oligomers and track conformational changes at a single-protein level. Here we tackled one of the most extreme protein behaviors, found recently in an inflammation pathway. Upon dan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb3f7fdf2097229051e0eea60634f47c
https://pubmed.ncbi.nlm.nih.gov/29526304
https://pubmed.ncbi.nlm.nih.gov/29526304
Autor:
Alun Jones, Thomas Durek, Zakir Tnimov, Sergey Mureev, Zhong Guo, Kirill Alexandrov, Zhenling Cui, Mark E. Polinkovsky
Publikováno v:
ACS synthetic biology. 6(3)
Incorporation of unnatural amino acids (uAAs) via codon reassignment is a powerful approach for introducing novel chemical and biological properties to synthesized polypeptides. However, the site-selective incorporation of multiple uAAs into polypept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598842c91e6b096d35e8feb56120b122
https://pubmed.ncbi.nlm.nih.gov/27966891
https://pubmed.ncbi.nlm.nih.gov/27966891
Autor:
Diya Rahman, Philip R. Nicovich, Emma Sierecki, Till Böcking, Nicholas Arrioti, Nichole Giles, Yann Gambin, Akshay Bhumkar, Quill Bowden, Robert G. Parton, Ian L. Ross, Janina Steinbeck, Mark E. Polinkovsky
Publikováno v:
Scientific Reports
Protein aggregation is a hallmark of many neurodegenerative diseases, notably Alzheimer’s and Parkinson’s disease. Parkinson’s disease is characterized by the presence of Lewy bodies, abnormal aggregates mainly composed of α-synuclein. Moreove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bd2eae0f4a48b834cd5744a9ad18a3
https://doi.org/10.1038/srep37630
https://doi.org/10.1038/srep37630
Autor:
Yann Gambin, Nichole Giles, Emma Sierecki, Mark E. Polinkovsky, Akshay Bhumkar, Bill Francois
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 17, Iss 5, p 655 (2016)
International Journal of Molecular Sciences, Vol 17, Iss 5, p 655 (2016)
Protein self-association is a key feature that can modulate the physiological role of proteins or lead to deleterious effects when uncontrolled. Protein oligomerization is a simple way to modify the activity of a protein, as the modulation of binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7139db34eb9364e4af11df489a2121b6
http://europepmc.org/articles/PMC4881481
http://europepmc.org/articles/PMC4881481