Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Mark E Issa"'
Autor:
Janna Krueger, Francois Santinon, Alexandra Kazanova, Mark E Issa, Bruno Larrivee, Richard Kremer, Catalin Milhalcioiu, Christopher E Rudd
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0251731 (2021)
Immunotherapy using checkpoint blockade (ICB) with antibodies such as anti-PD-1 has revolutionised the treatment of many cancers. Despite its use to treat COVID-19 patients and autoimmune diseases such as systemic lupus erythematosus and rheumatoid a
Externí odkaz:
https://doaj.org/article/9f8b53fa654645e1b8b5d394a55e2b73
Autor:
Diego Esperante, Mónica Itzel Martínez Gutiérrez, Mark E. Issa, Alejandro Schcolnik-Cabrera, Fela Mendlovic
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Energetic and nutritional requirements play a crucial role in shaping the immune cells that infiltrate tumor and parasite infection sites. The dynamic interaction between immune cells and the microenvironment, whether in the context of tumor or helmi
Externí odkaz:
https://doaj.org/article/d243ec947b3f48c8b25f07e95bc814f2
Autor:
A. A. Leslie Gunatilaka, Ya-Ming Xu, E. M. Kithsiri Wijeratne, Micaela F Freitas Misakyan, Mark E. Issa, Muriel Cuendet, Aymeric Monteillier
Publikováno v:
Journal of Natural Products. 84:2321-2335
Multiple myeloma (MM) is a hematological cancer in which relapse and resistance are highly frequent. Therefore, alternatives to conventional treatments are necessary. Withaferin A, a withanolide isolated from Withania somnifera, has previously shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcea6aaebd2a8729614dce8d2df8aebd
https://doi.org/10.1021/acs.jnatprod.1c00446
https://doi.org/10.1021/acs.jnatprod.1c00446
Glycogen Synthase Kinase-3 (GSK-3) Regulation of Inhibitory Coreceptor Expression in T-cell Immunity
Autor:
Mark E, Issa, Christopher E, Rudd
Publikováno v:
Journal of cellular immunology. 3(5)
The serine/threonine kinase, glycogen synthase kinase 3 (GSK-3) has been implicated in immune cell activation and function. Our recent studies have shown that the abrogation of GSK-3 activity down-regulates the expression of key inhibitory receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5586b87d650f817566ad2d8114a3b1e0
https://pubmed.ncbi.nlm.nih.gov/35693319
https://pubmed.ncbi.nlm.nih.gov/35693319
Publikováno v:
Proceedings, Vol 11, Iss 1, p 3 (2019)
Multiple myeloma is a hematological cancer characterized by the clonal proliferation of malignant plasma cells in the bone marrow. That disease has a rather low incidence but displays a high rate of relapse and resistance to conventional therapies. I
Externí odkaz:
https://doaj.org/article/368d1684736041999f5710d616a90adb
Autor:
Fan Huang, Christopher E. Rudd, Mark E. Issa, Jie Su, Tomasz Rzymski, Marina Gimeno, Connie M. Krawczyk, Audrey Emond, Magdalena Masiejczyk, Qianyu Guo, Nahum Sonenberg, Alexandre Benoit, Milena Mazan, Ghanem Elias Ghanem, Dany Plourde, Brendan Cordeiro, Sonia V. del Rincón, Natascha Gagnon, David Dankort, Margarita Bartish, Jacek Faber, Yao Zhan, Mikhael Attias, Elie Khoury, Joelle Rémy-Sarrazin, Christophe Goncalves, Ivan Topisirovic, Alba Galan, H. Uri Saragovi, Ciriaco A. Piccirillo, Fabrice Journe, Wilson H. Miller, William Yang
Publikováno v:
J Clin Invest
Melanomas commonly undergo a phenotype switch, from a proliferative to an invasive state. Such tumor cell plasticity contributes to immunotherapy resistance; however, the mechanisms are not completely understood and thus are therapeutically unexploit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d845fe7afdd091bb817c6503a5a7834
https://doi.org/10.1172/jci140752
https://doi.org/10.1172/jci140752
Autor:
Alexandra Kazanova, Mark E. Issa, Catalin Milhalcioiu, Janna Krueger, Francois Santinon, Bruno Larrivée, Christopher E. Rudd, Richard Kremer
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0251731 (2021)
PLoS ONE
PLoS ONE
Immunotherapy using checkpoint blockade (ICB) with antibodies such as anti-PD-1 has revolutionised the treatment of many cancers. Despite its use to treat COVID-19 patients and autoimmune diseases such as systemic lupus erythematosus and rheumatoid a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3603fe7649da15927b38c7fdbdf6f3cb
https://doaj.org/article/9f8b53fa654645e1b8b5d394a55e2b73
https://doaj.org/article/9f8b53fa654645e1b8b5d394a55e2b73
Publikováno v:
The Journal of Immunology. 208:176.07-176.07
Immune checkpoint blockade (ICB) of negative co-receptors on T-cells such as programmed cell death-1 (PD-1) is promising for the treatment of cancer. Despite success, the poor prognosis for most patients highlights the need for novel clinical interve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d58c74d24b6a598cda96fde9759a8a73
https://doi.org/10.4049/jimmunol.208.supp.176.07
https://doi.org/10.4049/jimmunol.208.supp.176.07
Autor:
Francois Santinon, Bruno Larrivée, Alexandra Kazanova, Mark E. Issa, Janna Kreuger, Catalin Milhalcioiu, Christopher E. Rudd
Coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a serious threat to global public health. Hydroxychloroquine (HCQ) and the antibiotic azithromycin (AZ) are still being used by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99d4927f615fce6204eb2a85c3d65d4e
https://doi.org/10.1101/2020.09.29.20193110
https://doi.org/10.1101/2020.09.29.20193110
Publikováno v:
Planta Medica, Vol. 84, No 9-10 (2018) pp. 653-661
The effects of genistein on angiogenesis remain poorly understood. Some studies claim an antiangiogenic effect and others claim a pro-angiogenic one. Thus, the aim of this study was to determine if genistein may exhibit bivalent angiogenic effects. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5c841fa1076c195d8041f6ae65ed03
https://doi.org/10.1055/a-0587-5991
https://doi.org/10.1055/a-0587-5991