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Akademický článek

NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens.

Autor: Anthony L Keyburn, John D Boyce, Paola Vaz, Trudi L Bannam, Mark E Ford, Dane Parker, Antonio Di Rubbo, Julian I Rood, Robert J Moore

Publikováno v: PLoS Pathogens, Vol 4, Iss 2, p e26 (2008)

For over 30 years a phospholipase C enzyme called alpha-toxin was thought to be the key virulence factor in necrotic enteritis caused by Clostridium perfringens. However, using a gene knockout mutant we have recently shown that alpha-toxin is not ess

Externí odkaz: https://doaj.org/article/092474610be145efa560831c3e650734

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Two putative zinc metalloproteases contribute to the virulence of Clostridium perfringens strains that cause avian necrotic enteritis

Autor: Anthony L. Keyburn, Mark E Ford, Robert J. Moore, Volker Haring, Ben Wade, Julian I. Rood

Publikováno v: Journal of Veterinary Diagnostic Investigation. 32:259-267

Two putative zinc metalloproteases encoded by Clostridium perfringens have been implicated in the pathogenesis of necrotic enteritis, an economically significant poultry disease that is caused by this anaerobic bacterium. These proteases have ~64% am

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eac0f9a8bdb89014d0eaa31e56b2071d
https://doi.org/10.1177/1040638719898689

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Protective efficacy afforded by live Pasteurella multocida vaccines in chickens is independent of lipopolysaccharide outer core structure

Autor: Conny Turni, Patrick J. Blackall, Marietta John, Mark E Ford, John D. Boyce, Ben Adler, Amy Wright, Mark L Edmunds, Andrew D. Cox, Marina Harper

Publikováno v: Vaccine. 34:1696-1703

Pasteurella multocida is a major animal pathogen that causes a range of diseases including fowl cholera. P. multocida infections result in considerable losses to layer and breeder flocks in poultry industries worldwide. Both killed whole-cell and liv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee17710e56b0f90a9687f44c3653119
https://doi.org/10.1016/j.vaccine.2016.02.017

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Clostridium perfringens-mediated necrotic enteritis is not influenced by the pre-existing microbiota but is promoted by large changes in the post-challenge microbiota

Autor: Priscilla A. Johanesen, Anthony L. Keyburn, Dena Lyras, Jake A. Lacey, Dragana Stanley, Honglei Chen, Robert J. Moore, Mark E Ford

Publikováno v: Veterinary microbiology. 227

Problem addressed: Clostridium perfringens is the etiological agent of necrotic enteritis in chickens. As necrotic enteritis is a gastrointestinal disease, the interactions of pathogenic C. perfringens strains with the complex microbiota of the gastr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3501bbe9657d5c858e5a375dbd2052b7
https://pubmed.ncbi.nlm.nih.gov/30473341

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Conjugation-Mediated Horizontal Gene Transfer of Clostridium perfringens Plasmids in the Chicken Gastrointestinal Tract Results in the Formation of New Virulent Strains

Autor: Priscilla A. Johanesen, Dena Lyras, Anthony L. Keyburn, Ricardo Wagner Portela, Robert J. Moore, Mark E Ford, Jake A. Lacey

Publikováno v: Applied and Environmental Microbiology. 83

Clostridium perfringens is a gastrointestinal pathogen capable of causing disease in a variety of hosts. Necrotic enteritis in chickens is caused by C. perfringens strains that produce the pore-forming toxin NetB, the major virulence factor for this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9a5035418789e88dbed36cfb1cbe77
https://doi.org/10.1128/aem.01814-17

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Characterization of Two Novel Lipopolysaccharide Phosphoethanolamine Transferases in Pasteurella multocida and Their Role in Resistance to Cathelicidin-2

Autor: Mark E Ford, Ben Adler, John D. Boyce, Frank St. Michael, Amy Wright, Marina Harper, Deanna Deveson Lucas, Jianjun Li, Andrew D. Cox

The lipopolysaccharide (LPS) produced by the Gram-negative bacterial pathogen Pasteurella multocida has phosphoethanolamine (PEtn) residues attached to lipid A, 3-deoxy- d -manno-octulosonic acid (Kdo), heptose, and galactose. In this report, we show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61a6ee4f313628044aff8f1372e79b47
https://europepmc.org/articles/PMC5649011/

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Natural Selection in the Chicken Host Identifies 3-Deoxy- d - manno - Octulosonic Acid Kinase Residues Essential for Phosphorylation of Pasteurella multocida Lipopolysaccharide

Autor: Andrew D. Cox, Mark E Ford, John D. Boyce, Ben Adler, Frank St. Michael, Ian W Wilkie, Marina Harper

Publikováno v: Infection and Immunity. 78:3669-3677

Pasteurella multocida is the causative agent of a number of diseases in animals, including fowl cholera. P. multocida strains simultaneously express two lipopolysaccharide (LPS) glycoforms (glycoforms A and B) that differ only in their inner core str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95d7fb24201191f3cce4d9dd6d8250d3
https://doi.org/10.1128/iai.00457-10

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Alpha-Toxin of Clostridium perfringens Is Not an Essential Virulence Factor in Necrotic Enteritis in Chickens

Autor: Robert J. Moore, Mark M Williamson, Milena M. Awad, Anthony L. Keyburn, Scott A Sheedy, Julian I. Rood, Mark E Ford

Publikováno v: Infection and Immunity. 74:6496-6500

The Clostridium perfringens alpha-toxin has previously been implicated as the major virulence factor in necrotic enteritis in chickens, although definitive proof has not been reported. In this study an alpha-toxin mutant was constructed in a virulent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd286025d35c4c34775eb7a2438ace0
https://doi.org/10.1128/iai.00806-06

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Vaccination with recombinant NetB toxin partially protects broiler chickens from necrotic enteritis

Autor: Xuxia Yan, Robert J. Moore, Anthony L. Keyburn, Trudi L. Bannam, Kathy Sproat, Mark E Ford, Ricardo Wagner Portela, Julian I. Rood

Publikováno v: Repositório Institucional da UFBA
Universidade Federal da Bahia (UFBA)
instacron:UFBA
Veterinary Research

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f5ce57ff8655fa3f860a2566b59989
http://repositorio.ufba.br/ri/handle/ri/15218

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Maternal immunization with vaccines containing recombinant NetB toxin partially protects progeny chickens from necrotic enteritis

Autor: Robert J. Moore, Anthony L. Keyburn, Julian I. Rood, Ricardo Wagner Portela, Xuxia Yan, Trudi L. Bannam, Mark E Ford

Publikováno v: Repositório Institucional da UFBA
Universidade Federal da Bahia (UFBA)
instacron:UFBA
Veterinary Research

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d494768d49e44ade189c5222d71dbb
http://repositorio.ufba.br/ri/handle/ri/14848

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