Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Mark E, Schmidt"'
Autor:
Nathalie Mertens, Mark E. Schmidt, Anja Hijzen, Donatienne Van Weehaeghe, Paulien Ravenstijn, Marleen Depre, Jan de Hoon, Koen Van Laere, Michel Koole
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract [18F]JNJ-64413739 has been evaluated as PET-ligand for in vivo quantification of purinergic receptor subtype 7 receptor (P2X7R) using Logan graphical analysis with a metabolite-corrected arterial plasma input function. In the context of a P2
Externí odkaz:
https://doaj.org/article/956ae6697f2b4d23a1f6acaf3aaf905f
Autor:
Yan Xu, Xin Miao, Paulien Ravenstijn, Anja Hijzen, Mark E. Schmidt, Partha Nandy, Honghui Zhou
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 309-317 (2020)
Positron emission tomography (PET) provides useful information in target engagement or receptor occupancy in the brain for central nervous system (CNS) drug development, however, dose selection for human PET studies is challenging and largely empiric
Externí odkaz:
https://doaj.org/article/d20afbe76b7844baaac6ee5ea1578e10
Autor:
Dawn C. Matthews, Ana S. Lukic, Randolph D. Andrews, Miles N. Wernick, Stephen C. Strother, Mark E. Schmidt, for the Alzheimer's Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Amyloid measurement provides important confirmation of pathology for Alzheimer's disease (AD) clinical trials. However, many amyloid positive (Am+) early‐stage subjects do not worsen clinically during a clinical trial, and a n
Externí odkaz:
https://doaj.org/article/fe825d9fea5c446f92ce531936bd978c
Autor:
Pawel J. Markiewicz, Julian C. Matthews, John Ashburner, David M. Cash, David L. Thomas, Enrico De Vita, Anna Barnes, M. Jorge Cardoso, Marc Modat, Richard Brown, Kris Thielemans, Casper da Costa-Luis, Isadora Lopes Alves, Juan Domingo Gispert, Mark E. Schmidt, Paul Marsden, Alexander Hammers, Sebastien Ourselin, Frederik Barkhof
Publikováno v:
NeuroImage, Vol 232, Iss , Pp 117821- (2021)
Accurate regional brain quantitative PET measurements, particularly when using partial volume correction, rely on robust image registration between PET and MR images. We argue here that the precision, and hence the uncertainty, of MR-PET image regist
Externí odkaz:
https://doaj.org/article/927d5c4df2d64780bd6c99b19e604971
Autor:
Johannes Streffer, Valerie Treyer, Alfred Buck, Simon M. Ametamey, Milen Blagoev, Ralph P Maguire, Aurélie Gautier, Yves P. Auberson, Mark E. Schmidt, Ivan-Toma Vranesic, Baltazar Gomez-Mancilla, Fabrizio Gasparini
Publikováno v:
NeuroImage, Vol 230, Iss , Pp 117785- (2021)
Mavoglurant binds to same allosteric site on metabotropic glutamate receptor 5 (mGluR5) as [11C]-ABP688, a radioligand. This open-label, single-center pilot study estimates extent of occupancy of mGluR5 receptors following single oral doses of mavogl
Externí odkaz:
https://doaj.org/article/ade72d8efd5c49d88ff715c43ad5a8a3
Autor:
Mara ten Kate, Silvia Ingala, Adam J. Schwarz, Nick C. Fox, Gaël Chételat, Bart N. M. van Berckel, Michael Ewers, Christopher Foley, Juan Domingo Gispert, Derek Hill, Michael C. Irizarry, Adriaan A. Lammertsma, José Luis Molinuevo, Craig Ritchie, Philip Scheltens, Mark E. Schmidt, Pieter Jelle Visser, Adam Waldman, Joanna Wardlaw, Sven Haller, Frederik Barkhof
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-21 (2018)
Abstract Background In Alzheimer’s disease (AD), pathological changes may arise up to 20 years before the onset of dementia. This pre-dementia window provides a unique opportunity for secondary prevention. However, exposing non-demented subjects to
Externí odkaz:
https://doaj.org/article/6bc4725c1a6e4d89b738578c6a2ba6cf
Autor:
Jelle Praet, Nikolay V. Manyakov, Leacky Muchene, Zhenhua Mai, Vasilis Terzopoulos, Steve de Backer, An Torremans, Pieter-Jan Guns, Tom Van De Casteele, Astrid Bottelbergs, Bianca Van Broeck, Jan Sijbers, Dirk Smeets, Ziv Shkedy, Luc Bijnens, Darrel J. Pemberton, Mark E. Schmidt, Annemie Van der Linden, Marleen Verhoye
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-16 (2018)
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the elderly population. In this study, we used the APP/PS1 transgenic mouse model to explore the feasibility of using
Externí odkaz:
https://doaj.org/article/2e0e17af4d50440b83a9140322f6cfeb
Autor:
Mark E. Schmidt, Michel Koole, Jan de Hoon, Donatienne Van Weehaeghe, Paulien Ravenstijn, Koen Van Laere, Marleen Depré, Nathalie Mertens, Anja Hijzen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
[18F]JNJ-64413739 has been evaluated as PET-ligand for in vivo quantification of purinergic receptor subtype 7 receptor (P2X7R) using Logan graphical analysis with a metabolite-corrected arterial plasma input function. In the context of a P2X7R PET d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c591cbad0fa71947c8fad7aafdc84042
https://doaj.org/article/956ae6697f2b4d23a1f6acaf3aaf905f
https://doaj.org/article/956ae6697f2b4d23a1f6acaf3aaf905f
Autor:
Suzanne L. Baker, Maarten Timmers, Mark E. Schmidt, William J. Jagust, Wesley Thomas, Hartmuth C. Kolb, Karine Provost, A. J. Whitman, Gil D. Rabinovici, Mustafa Janabi
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 41:3302-3313
The [18F]-JNJ-64326067-AAA ([18F]-JNJ-067) tau tracer was evaluated in healthy older controls (HCs), mild cognitive impairment (MCI), Alzheimer’s disease (AD), and progressive supranuclear palsy (PSP) participants. Seventeen subjects (4 HCs, 5 MCIs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c061966277a7e1a3c61caf0125f254a0
https://doi.org/10.1177/0271678x211031035
https://doi.org/10.1177/0271678x211031035
Autor:
Dawn C. Matthews, Mark E. Schmidt
Publikováno v:
Alzheimer's Disease Drug Development ISBN: 9781108975759
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0653270dc4557797882fae69fde6364a
https://doi.org/10.1017/9781108975759.034
https://doi.org/10.1017/9781108975759.034
