Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Mark E, McComb"'
Autor:
Di Shao, Chunxiang Yao, Maya H. Kim, Jessica Fry, Richard A. Cohen, Catherine E. Costello, Reiko Matsui, Francesca Seta, Mark E. McComb, Markus M. Bachschmid
Publikováno v:
Redox Biology, Vol 22, Iss , Pp - (2019)
Sirtuin-1 (SirT1) catalyzes NAD+-dependent protein lysine deacetylation and is a critical regulator of energy and lipid metabolism, mitochondrial biogenesis, apoptosis, and senescence. Activation of SirT1 mitigates metabolic perturbations associated
Externí odkaz:
https://doaj.org/article/007efb9834d74e2bab6db56ca200aba3
Autor:
Syed Husain Mustafa Rizvi, David R. Pimentel, Robert M. Weisbrod, Yuko Tsukahara, Naomi M. Hamburg, Di Shao, Markus Bachschmid, Mark E. McComb, Reiko Matsui
Publikováno v:
Free Radic Biol Med
Aims S-glutathionylation is a reversible oxidative modification of protein cysteines that plays a critical role in redox signaling. Glutaredoxin-1 (Glrx), a glutathione-specific thioltransferase, removes protein S-glutathionylation. Glrx, though a cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd68205d83f6f349815d4d1f9ec58d8
https://doi.org/10.1016/j.freeradbiomed.2021.07.037
https://doi.org/10.1016/j.freeradbiomed.2021.07.037
Autor:
Kevin B. Chandler, Paola Divieti Pajevic, Catherine E. Costello, Yuhei Uda, Veronica Lu, Ningyuan Sun, Amira I. Hussein, Raghad Shuwaikan, Mark E. McComb, Ehab Azab
Publikováno v:
FASEB J
Osteocytes, the bone cells embedded in the mineralized matrix, control bone modeling and remodeling through direct contact with adjacent cells and via paracrine and endocrine factors that affect cells in the bone marrow microenvironment or distant or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e9d42e5e5f2d7f1e328f4c3bf4650b
https://doi.org/10.1096/fj.202000366r
https://doi.org/10.1096/fj.202000366r
Autor:
Chunxiang Yao, Jessica B Behring, Di Shao, Aaron L Sverdlov, Stephen A Whelan, Aly Elezaby, Xiaoyan Yin, Deborah A Siwik, Francesca Seta, Catherine E Costello, Richard A Cohen, Reiko Matsui, Wilson S Colucci, Mark E McComb, Markus M Bachschmid
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144025 (2015)
Reactive protein cysteine thiolates are instrumental in redox regulation. Oxidants, such as hydrogen peroxide (H2O2), react with thiolates to form oxidative post-translational modifications, enabling physiological redox signaling. Cardiac disease and
Externí odkaz:
https://doaj.org/article/17226e23b1354d9a9df939a220b367f6
Autor:
Yvonne M. W. Janssen-Heininger, Beatriz Ferrán, Brian S. H. Chong, Yoshimitsu Yura, Richard A. Cohen, Yosuke Watanabe, Colin E. Murdoch, Mark E. McComb, Yuko Tsukahara, Markus Bachschmid, Reiko Matsui, Jessica B. Behring, Ryan D. Johnson, Catherine E. Costello
Publikováno v:
FASEB J
Glutaredoxin-1 (Glrx) is a small cytosolic enzyme that removes S-glutathionylation, glutathione adducts of protein cysteine residues, thus modulating redox signaling and gene transcription. Although Glrx up-regulation prevented endothelial cell (EC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbe2948a57f26b10f0c4f68b5fe0730
https://doi.org/10.1096/fj.201900786r
https://doi.org/10.1096/fj.201900786r
Autor:
Carlos Villacorta-Martin, Shaghayegh Farhangmehr, Ryan M. Hekman, Mohsan Saeed, Carlos Perea-Resa, Robert A. Davey, Andrew Emili, Jian Zhao, Peter E.A. Ash, Raghuveera Kumar Goel, Benjamin C. Blum, Andrew A. Wilson, Benjamin J. Blencowe, Ulrich Braunschweig, Benjamin Wolozin, Andrew Tilston-Lunel, Darrell N. Kotton, Ji-Xin Cheng, Avik Basu, Alexandra Mora-Martin, Esther Bullitt, Rhiannon B. Werder, Mark E. McComb, Dmitry A. Kretov, Dzmitry Padhorny, Sandeep Ojha, Shawn M. Lyons, Konstantinos D. Alysandratos, Jessie Huang, Anne Hinds, Valentina Perissi, J. J. Patten, Ahmed Youssef, Xaralabos Varelas, John H Connor, Dima Kozakov, Mamta Verma, Dante Bolzan, Indranil Paul, Ellen L Suder, Eric J. Burks, Matthew D. Layne, Elke Mühlberger, Stefan Wuchty, Adam J. Hume, Daniel Cifuentes, Sadhna Phanse, Julian H. Kwan, Michael D. Blower, Kristine M. Abo
Publikováno v:
Molecular Cell
Human transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causative pathogen of the COVID-19 pandemic, exerts a massive health and socioeconomic crisis. The virus infects alveolar epithelial type 2 cells (AT2s), leading to l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469deb34c0395f965c7f17d2e99c8022
Autor:
Kshitij Khatri, Chun Shao, Nicole K. Polinski, Joseph Zaia, Rekha Raghunathan, Deborah R. Leon, Fredric P. Manfredsson, Mark E. McComb, Joshua A. Klein, John D. Hogan, Caryl E. Sortwell
Publikováno v:
Molecular & Cellular Proteomics. 17:1778-1787
Parkinson's disease (PD) is a neurological disorder characterized by the progressive loss of functional dopaminergic neurons in the nigrostriatal pathway in the brain. Although current treatments provide only symptomatic relief, gene therapy has the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a010b58bc7a572ac17c064deadddce
https://doi.org/10.1074/mcp.ra118.000680
https://doi.org/10.1074/mcp.ra118.000680
Autor:
Deborah R. Leon, Joshua A. Klein, Joseph Zaia, John R. Haserick, Mark E. McComb, Kshitij Khatri, Catherine E. Costello
Publikováno v:
Analytical Chemistry. 89:6645-6655
Glycomics and glycoproteomics analyses by mass spectrometry require efficient front-end separation methods to enable deep characterization of heterogeneous glycoform populations. Chromatography methods are generally limited in their ability to resolv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6631ff78fc17c7def03b22b245c01690
https://doi.org/10.1021/acs.analchem.7b00875
https://doi.org/10.1021/acs.analchem.7b00875
Autor:
Nathan Bushue, Zhen Zhang, Mark E. McComb, Luciano DiTacchio, Catherine E. Costello, Stephen A. Whelan, Chad Slawson, Ee Phie Tan, Kenneth R. Peterson, Flávia C. Costa
Publikováno v:
Journal of Biological Chemistry. 291:15628-15640
One mode of γ-globin gene silencing involves a GATA-1·FOG-1·Mi2β repressor complex that binds to the -566 GATA site relative to the (A)γ-globin gene cap site. However, the mechanism of how this repressor complex is assembled at the -566 GATA sit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a057d9b100042b076e58f5fc1b66598
https://doi.org/10.1074/jbc.m116.721928
https://doi.org/10.1074/jbc.m116.721928
Autor:
Catherine E. Costello, Katia C. Gondim, Stephen A. Whelan, Miguel C. Lucena, Monica M. Marinho-Carvalho, Isadora A. Oliveira, Wagner B. Dias, Adriane R. Todeschini, Iron F. De Paula, Patricia Carvalho-cruz, Mauro Sola-Penna, Mark E. McComb, Rafaela Muniz de Queiroz, Joana L. Donadio
Publikováno v:
Journal of Biological Chemistry. 291:12917-12929
Deregulated cellular metabolism is a hallmark of tumors. Cancer cells increase glucose and glutamine flux to provide energy needs and macromolecular synthesis demands. Several studies have been focused on the importance of glycolysis and pentose phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fffbbb001d881de36d0f24f39e5cec
https://doi.org/10.1074/jbc.m116.729236
https://doi.org/10.1074/jbc.m116.729236