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Akademický článek

Synaptic loss and its association with symptom severity in Parkinson’s disease

Publikováno v: npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-9 (2024)

Abstract Parkinson’s disease (PD) is the fastest growing neurodegenerative disease, but at present there is no cure, nor any disease-modifying treatments. Synaptic biomarkers from in vivo imaging have shown promise in imaging loss of synapses in PD

Externí odkaz: https://doaj.org/article/f8c1054730b44122933ba28992365acc

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Time to shunt failure in children with myelomeningocele: an analysis of the National Spina Bifida Patient Registry

Autor: Brandon G. Rocque, Betsy Hopson, Isaac Shamblin, Tiebin Liu, Elisabeth Ward, Robin Bowman, Andrew B. Foy, Mark Dias, Gregory G. Heuer, Kathryn Smith, Jeffrey P. Blount

Publikováno v: Journal of Neurosurgery: Pediatrics. 30:484-489

OBJECTIVE Hydrocephalus is common among children with myelomeningocele and is most frequently treated with a ventriculoperitoneal shunt (VPS). Although much is known about factors related to first shunt failure, relatively less data are available abo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d4d171b76f50309e2c2eb77a669e09f
https://doi.org/10.3171/2022.7.peds22224

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Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults

Autor: David Matuskey, Jean-Dominique Gallezot, Nabeel Nabulsi, Shannan Henry, Kristen Torres, Mark Dias, Gustavo A Angarita, Yiyun Huang, Susan E Shoaf, Richard E Carson, Shailly Mehrotra

Publikováno v: Journal of psychopharmacology (Oxford, England).

Background: Centanafadine is an inhibitor of reuptake transporters for norepinephrine (NET), dopamine (DAT) and serotonin (SERT). Aims: This phase 1, adaptive-design positron emission tomography study investigated the occupancy time course of NET, DA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200f7bb4bae6d86c839e51e59f5075d5
https://pubmed.ncbi.nlm.nih.gov/36515395

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Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [ 11 C]UCB‐J positron emission tomography study

Autor: Yihuan Lu, Mark Dias, Nabeel Nabulsi, Richard E. Carson, Yiyun Huang, Qianyu Wang, Dennis D. Spencer, Ming-Kai Chen, Jean-Dominique Gallezot, Sjoerd J. Finnema, Mika Naganawa, Shu-fei Lin, Takuya Toyonaga, Kamil Detyniecki

Publikováno v: Epilepsia. 61:2183-2193

OBJECTIVE In this positron emission tomography (PET) study with [11 C]UCB-J, we evaluated synaptic vesicle glycoprotein 2A (SV2A) binding, which is decreased in resected brain tissues from epilepsy patients, in subjects with temporal lobe epilepsy (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bde6e8c375c2d51cc4da96ca2b9a565
https://doi.org/10.1111/epi.16653

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Synaptic Changes in Parkinson Disease Assessed with in vivo Imaging

Autor: Ivonne Suridjan, Mark Dias, Sjoerd J. Finnema, Nabeel Nabulsi, Yiyun Huang, David Matuskey, Kyle C. Wilcox, Takuya Toyonaga, Richard E. Carson, Jim Ropchan, Brian Pittman, Shannan Henry, Mika Naganawa, Sule Tinaz, Robert A. Comley

Publikováno v: Annals of Neurology

Objective Parkinson disease is characterized by motor and nonmotor symptoms, reduced striatal dopamine signaling, and loss of dopamine neurons in the substantia nigra. It is now known that the pathological process in Parkinson disease may begin decad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de6aaf38d4fec52872144d7772cc873
https://doi.org/10.1002/ana.25682

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Assessment of population-based input functions for Patlak imaging of whole body dynamic 18F-FDG PET

Autor: Vijay Shah, Mark Dias, Richard E. Carson, Jean-Dominique Gallezot, Tim Mulnix, Mika Naganawa, Anne M. Smith, Colin R Young, Ming-Kai Chen

Publikováno v: EJNMMI Physics. 7

BackgroundArterial blood sampling is the gold standard method to obtain the arterial input function (AIF) for quantification of whole body (WB) dynamic18F-FDG PET imaging. However, this procedure is invasive and not typically available in clinical en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae3856d133c8a5e392b8abab6c033f3b
https://doi.org/10.1186/s40658-020-00330-x

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Assessment of population-based input functions for Patlak imaging of whole body dynamic

Autor: Mika, Naganawa, Jean-Dominique, Gallezot, Vijay, Shah, Tim, Mulnix, Colin, Young, Mark, Dias, Ming-Kai, Chen, Anne M, Smith, Richard E, Carson

Publikováno v: EJNMMI Physics

Background Arterial blood sampling is the gold standard method to obtain the arterial input function (AIF) for quantification of whole body (WB) dynamic 18F-FDG PET imaging. However, this procedure is invasive and not typically available in clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::94b9c04f4cf503f7a54574cb6cf7397d
https://pubmed.ncbi.nlm.nih.gov/33226522

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Reduced synaptic vesicle protein 2A binding in temporal lobe epilepsy: A [

Autor: Sjoerd J, Finnema, Takuya, Toyonaga, Kamil, Detyniecki, Ming-Kai, Chen, Mark, Dias, Qianyu, Wang, Shu-Fei, Lin, Mika, Naganawa, Jean-Dominique, Gallezot, Yihuan, Lu, Nabeel B, Nabulsi, Yiyun, Huang, Dennis D, Spencer, Richard E, Carson

Publikováno v: EpilepsiaREFERENCES. 61(10)

In this positron emission tomography (PET) study with [Twelve TLE subjects and 12 control subjects were examined. Regional [In 11 TLE subjects with medial temporal lobe sclerosis (MTS), the hippocampal volumetric asymmetry was 25 ± 11%. After PVC, [

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c49fb91978496816041ec9bee762676e
https://pubmed.ncbi.nlm.nih.gov/32944949

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