Výsledky vyhledávání - "Mark Dewhirst"

The complex ecosystem in which tumor cells reside and interact, termed the tumor microenvironment (TME), encompasses all cells and components associated with a neoplasm that are not transformed cells. Interactions between tumor cells and the TME are

Externí odkaz: https://doaj.org/article/83c7fcdb323840239594f1192726822b

Zobrazit plný text záznamu

Akademický článek

Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo

Autor: Seth T. Gammon, Federica Pisaneschi, Madhavi L. Bandi, Melinda G. Smith, Yuting Sun, Yi Rao, Florian Muller, Franklin Wong, John De Groot, Jeffrey Ackroyd, Osama Mawlawi, Michael A. Davies, Y.N. Vashisht Gopal, M. Emilia Di Francesco, Joseph R. Marszalek, Mark Dewhirst, David Piwnica-Worms

Publikováno v: Cells, Vol 8, Iss 12, p 1487 (2019)

Tumors lack a well-regulated vascular supply of O2 and often fail to balance O2 supply and demand. Net O2 tension within many tumors may not only depend on O2 delivery but also depend strongly on O2 demand. Thus, tumor O2 consumption rates may influe

Externí odkaz: https://doaj.org/article/80e43aa655ad4afda9d992b8b65f87d1

Zobrazit plný text záznamu

Plný text ve formátu HTML

Akademický článek

Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude.

Autor: Daniel Radiloff, Yulin Zhao, Alina Boico, Gert Blueschke, Gregory Palmer, Andrew Fontanella, Mark Dewhirst, Claude A Piantadosi, Robert Noveck, David Irwin, Karyn Hamilton, Bruce Klitzman, Thies Schroeder

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e99309 (2014)

Rapid ascent to high altitude causes illness and fatigue, and there is a demand for effective acute treatments to alleviate such effects. We hypothesized that increased oxygen delivery to the tissue using a combination of a hypertensive agent and an

Externí odkaz: https://doaj.org/article/26f792ad31b6433f9c82cbd1b38d1566

Zobrazit plný text záznamu

Akademický článek

The genomic analysis of lactic acidosis and acidosis response in human cancers.

Autor: Julia Ling-Yu Chen, Joseph E Lucas, Thies Schroeder, Seiichi Mori, Jianli Wu, Joseph Nevins, Mark Dewhirst, Mike West, Jen-Tsan Chi

Publikováno v: PLoS Genetics, Vol 4, Iss 12, p e1000293 (2008)

The tumor microenvironment has a significant impact on tumor development. Two important determinants in this environment are hypoxia and lactic acidosis. Although lactic acidosis has long been recognized as an important factor in cancer, relatively l

Externí odkaz: https://doaj.org/article/23fd5bbd06b848649aaed526c6b8b8ae

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání