Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Mark Denham"'
Autor:
Katelyn Cahill, Shermiyah Rienecker, Patrick O'Connor, Mark Denham, Francis Gibbons, David Willis, Dinesh Vignarajah, Nicole Buddle, Myo Min
Publikováno v:
Journal of Medical Radiation Sciences, Vol 70, Iss 4, Pp 498-508 (2023)
Abstract Magnetic resonance imaging (MRI) is being integrated into routine radiation therapy (RT) planning workflows. To reap the benefits of this imaging modality, patient positioning, image acquisition parameters and a quality assurance programme m
Externí odkaz:
https://doaj.org/article/ab2ed8a8528a4fba9bbab9275c8d91b5
Autor:
Muyesier Maimaitili, Muwan Chen, Fabia Febbraro, Ekin Ucuncu, Rachel Kelly, Jonathan Christos Niclis, Josefine Rågård Christiansen, Noëmie Mermet-Joret, Dragos Niculescu, Johanne Lauritsen, Angelo Iannielli, Ida H. Klæstrup, Uffe Birk Jensen, Per Qvist, Sadegh Nabavi, Vania Broccoli, Anders Nykjær, Marina Romero-Ramos, Mark Denham
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Current differentiation protocols for generating mesencephalic dopaminergic (mesDA) neurons from human pluripotent stem cells result in grafts containing only a small proportion of mesDA neurons when transplanted in vivo. In this study, we d
Externí odkaz:
https://doaj.org/article/cabafdbe91e44ff087afd66e98f70397
Autor:
Ensieh Farahani, Line S. Reinert, Ryo Narita, Manutea C. Serrero, Morten Kelder Skouboe, Demi van der Horst, Sonia Assil, Baocun Zhang, Marie B. Iversen, Eugenio Gutierrez, Hossein Hazrati, Mogens Johannsen, David Olagnier, Reiner Kunze, Mark Denham, Trine H. Mogensen, Michael Lappe, Søren R. Paludan
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113792- (2024)
Summary: Pattern recognition receptors (PRRs) induce host defense but can also induce exacerbated inflammatory responses. This raises the question of whether other mechanisms are also involved in early host defense. Using transcriptome analysis of di
Externí odkaz:
https://doaj.org/article/44f664b9af4a437aa62a40c3c3077e62
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102451- (2023)
Summary: Here, we present a protocol for generating miniaturized controlled midbrain organoids (MiCOs) of reproducible size and cellular composition, without a necrotic center. We describe steps for maintaining and passaging human pluripotent stem ce
Externí odkaz:
https://doaj.org/article/d16395151bc94671b04ab9481ec53b25
Autor:
Tobias Bergmann, Yong Liu, Jonathan Skov, Leo Mogus, Julie Lee, Ulrich Pfisterer, Louis-Francois Handfield, Andrea Asenjo-Martinez, Irene Lisa-Vargas, Stefan E. Seemann, Jimmy Tsz Hang Lee, Nikolaos Patikas, Birgitte Rahbek Kornum, Mark Denham, Poul Hyttel, Menno P. Witter, Jan Gorodkin, Tune H. Pers, Martin Hemberg, Konstantin Khodosevich, Vanessa Jane Hall
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Stellate cells are principal neurons in the entorhinal cortex that contribute to spatial processing. They also play a role in the context of Alzheimer’s disease as they accumulate Amyloid beta early in the disease. Producing human stellate cells fr
Externí odkaz:
https://doaj.org/article/33496e16dde243a0a9478f786050d0ba
Autor:
Muwan Chen, Muyesier Maimaitili, Mette Habekost, Katherine P. Gill, Noëmie Mermet-Joret, Sadegh Nabavi, Fabia Febbraro, Mark Denham
Publikováno v:
Stem Cell Research, Vol 48, Iss , Pp 101945- (2020)
The differentiation of patient-specific induced pluripotent stem cells (iPSCs) into specific neuronal subtypes has been exploited as an approach for modeling a variety of neurological disorders. However, achieving a highly pure population of neurons
Externí odkaz:
https://doaj.org/article/22eaa1b9a92d4a05ac9f38b727a66b06
Publikováno v:
Stem Cell Research, Vol 48, Iss , Pp 101984- (2020)
Direct neuronal conversion describes the process of generating induced neurons from somatic cells such as fibroblasts by overexpressing cell type-specific transcription factors, microRNAs or by culturing in the presence of small molecules. This was f
Externí odkaz:
https://doaj.org/article/95ea23caf1254e61865b2935584e05e3
Autor:
Muwan Chen, Muyesier Maimaitili, Susanne Hvolbøl Buchholdt, Uffe Birk Jensen, Fabia Febbraro, Mark Denham
Publikováno v:
Stem Cell Research, Vol 45, Iss , Pp - (2020)
We generated an induced pluripotent stem cell (iPSC) line from fibroblasts of a clinically diagnosed 70 year old female Parkinson's disease (PD) patient heterozygous for a pathogenic missense variant (p.G2019S; c. 6055 G > A) in the leucine-rich repe
Externí odkaz:
https://doaj.org/article/a393827b102b4353ae071d07fdffc349
Autor:
Muwan Chen, Muyesier Maimaitili, Susanne Hvolbøl Buchholdt, Uffe Birk Jensen, Fabia Febbraro, Mark Denham
Publikováno v:
Stem Cell Research, Vol 42, Iss , Pp - (2020)
We generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes includin
Externí odkaz:
https://doaj.org/article/2763008b69d0437fb19115ea4e86e791
Publikováno v:
Stem Cell Research, Vol 41, Iss , Pp - (2019)
Porcine embryonic and induced pluripotent stem cells (ESCs; iPSCs) have proven difficult to derive and maintain in vitro. This may be due to inappropriate culturing conditions and incomplete activation of proper pluripotency networks. To this end, we
Externí odkaz:
https://doaj.org/article/7504aa01febb4032a6ff21a2ae433ae3