Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mark Dedden"'
Autor:
Maximilian Wiendl, Mark Dedden, Li-Juan Liu, Anna Schweda, Eva-Maria Paap, Karen A.-M. Ullrich, Leonie Hartmann, Luisa Wieser, Francesco Vitali, Imke Atreya, Tanja M. Müller, Claudia Günther, Raja Atreya, Markus F. Neurath, Sebastian Zundler
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Despite promising preclinical and earlier clinical data, a recent phase III trial on the anti-β7 integrin antibody etrolizumab in Crohn’s disease (CD) did not reach its primary endpoint. The mechanisms leading to this outcome are not well
Externí odkaz:
https://doaj.org/article/acac8322e2ba43b1966b2f33b0b17d77
Autor:
Katrin Sommer, Karin Heidbreder, Lucas Kreiss, Mark Dedden, Eva‐Maria Paap, Maximilian Wiendl, Emily Becker, Raja Atreya, Tanja M. Müller, Imke Atreya, Maximilian Waldner, Sebastian Schürmann, Oliver Friedrich, Markus F. Neurath, Sebastian Zundler
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 4, Pp n/a-n/a (2023)
Abstract Background Closing mucosal defects to reach mucosal healing is an important goal of therapy in inflammatory bowel disease (IBD). Among other cells, monocyte‐derived macrophages are centrally involved in such intestinal wound healing. We ha
Externí odkaz:
https://doaj.org/article/ac3db3afc3cb4b44b45838ef0d030115
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSingle cell RNA sequencing plays an increasing and indispensable role in immunological research such as in the field of inflammatory bowel diseases (IBD). Professional pipelines are complex, but tools for the manual selection and further
Externí odkaz:
https://doaj.org/article/a109f8b96a354c2ab6943f7d212e6c06
Autor:
Salvador Cazorla-Vázquez, Peter Kösters, Simone Bertz, Frederick Pfister, Christoph Daniel, Mark Dedden, Sebastian Zundler, Tilman Jobst-Schwan, Kerstin Amann, Felix B. Engel
Publikováno v:
Cells, Vol 12, Iss 15, p 1988 (2023)
Adhesion G protein-coupled receptors (aGPCRs) comprise the second-largest class of GPCRs, the most common target for approved pharmacological therapies. aGPCRs play an important role in development and disease and have recently been associated with t
Externí odkaz:
https://doaj.org/article/fa43d8788f544b4487d78515f8317ff8
Autor:
Tanja M. Müller, Li-Juan Liu, Tina Czerwinski, Manuel Wiesinger, Mark Dedden, Eva-Maria Paap, Karen A.-M. Ullrich, Imke Atreya, Britta Siegmund, Raja Atreya, Ben Fabry, Carola Berking, Markus F. Neurath, Sebastian Zundler, Caroline J. Voskens
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology.
Autor:
Imke Atreya, Arif B. Ekici, Mark Dedden, Tanja M. Müller, Christine M. Gall, Raja Atreya, Anja Schulz-Kuhnt, Sebastian Zundler, Francesco Vitali, Anna Schweda, Caroline J. Voskens, Ahmed N. Hegazy, Emily Becker, Markus F. Neurath, Maximilian Wiendl
Publikováno v:
Gut. 71:1551-1566
ObjectiveThe anti-α4β7 integrin antibody vedolizumab is administered at a fixed dose for the treatment of IBDs. This leads to a wide range of serum concentrations in patients and previous studies had suggested that highest exposure levels are assoc
Autor:
Emily, Becker, Mark, Dedden, Christine, Gall, Maximilian, Wiendl, Arif Bülent, Ekici, Anja, Schulz-Kuhnt, Anna, Schweda, Caroline, Voskens, Ahmed, Hegazy, Francesco, Vitali, Raja, Atreya, Tanja Martina, Müller, Imke, Atreya, Markus F, Neurath, Sebastian, Zundler
Publikováno v:
Gut. 71(8)
The anti-α4β7 integrin antibody vedolizumab is administered at a fixed dose for the treatment of IBDs. This leads to a wide range of serum concentrations in patients and previous studies had suggested that highest exposure levels are associated wit
Autor:
Carolina Ornelas-Fuentes, Mirna Martínez-Saucedo, Guillermo Aquino-Jarquin, Hector Diaz-Garcia, Mark Dedden, Rodrigo Moreno-Salgado, Rocío Sánchez-Urbina, Javier T. Granados-Riveron
Publikováno v:
The journal of gene medicineREFERENCES. 22(5)
Background Focal dermal hypoplasia (FDH) is rare X-linked dominant disease characterized by atrophy and linear pigmentation of the skin, split hand/foot deformities and ocular anomalies. FDH is caused by mutations of the Porcupine (PORCN) gene, which
Autor:
Paul B. Stege, Maud Hamer, Willem van Schaik, Vincent de Maat, Jan-Peter van Pijkeren, Mark Dedden, Rob J. L. Willems
Publikováno v:
FEMS microbiology letters, 366(22)
The Gram-positive bacterium Enterococcus faecium is becoming increasingly prevalent as a cause of hospital-acquired, antibiotic-resistant infections. A fundamental part of research into E. faecium biology relies on the ability to generate targeted mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121e8dea6afafc19184c38cb2bbe3f60
https://dspace.library.uu.nl/handle/1874/391928
https://dspace.library.uu.nl/handle/1874/391928
Autor:
Guillermo Aquino-Jarquin, Patricia Baeza-Capetillo, Jesús Aguirre-Hernández, Yolanda Bárcenas-Gómez, Samara Téllez-Camacho, Mirna Martínez-Saucedo, Javier T. Granados-Riveron, Rocío Sánchez-Urbina, Mark Dedden
Publikováno v:
The Journal of Gene Medicine. 21
Background MicroRNAs (miRNAs) modulate gene expression through destabilization or translational inhibition of cytoplasmic transcripts or by transcriptional regulation through binding to genomic DNA. Although miRNAs are globally down-regulated in canc