Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Mark D. Starr"'
Autor:
Alex S. Choi, Laura M. Jenkins-Lane, Wade Barton, Asha Kumari, Carly Lancaster, Calen Raulerson, Hao Ji, Diego Altomare, Mark D. Starr, Regina Whitaker, Rebecca Phaeton, Rebecca Arend, Michael Shtutman, Andrew B. Nixon, Nadine Hempel, Nam Y. Lee, Karthikeyan Mythreye
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-21 (2024)
Abstract In pathologies including cancer, aberrant Transforming Growth Factor-β (TGF-β) signaling exerts profound tumor intrinsic and extrinsic consequences. Intense clinical endeavors are underway to target this pathway. Central to the success of
Externí odkaz:
https://doaj.org/article/ed54a9e793e64950bc11bf6731d8ff90
Autor:
Sarah E. Wetzel-Strong, Shantel Weinsheimer, Jeffrey Nelson, Ludmila Pawlikowska, Dewi Clark, Mark D. Starr, Yingmiao Liu, Helen Kim, Marie E. Faughnan, Andrew B. Nixon, Douglas A. Marchuk
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-10 (2021)
Abstract Background Vascular malformations in the central nervous system are difficult to monitor and treat due to their inaccessible location. Angiogenic and inflammatory proteins are secreted into the bloodstream and may serve as useful biomarkers
Externí odkaz:
https://doaj.org/article/d85e9edd018b48bd8a324e4faa6a3311
Autor:
Zainab Shonibare, Mehri Monavarian, Kathleen O’Connell, Diego Altomare, Abigail Shelton, Shubham Mehta, Renata Jaskula-Sztul, Rebecca Phaeton, Mark D. Starr, Regina Whitaker, Andrew Berchuck, Andrew B. Nixon, Rebecca C. Arend, Nam Y. Lee, C. Ryan Miller, Nadine Hempel, Karthikeyan Mythreye
Publikováno v:
Cell Reports, Vol 40, Iss 4, Pp 111066- (2022)
Summary: Growth factors in tumor environments are regulators of cell survival and metastasis. Here, we reveal the dichotomy between TGF-β superfamily growth factors BMP and TGF-β/activin and their downstream SMAD effectors. Gene expression profilin
Externí odkaz:
https://doaj.org/article/20e1a0843b1f45028091a733956f68ac
Autor:
Sharareh Siamakpour-Reihani, Felicia Cao, Jing Lyu, Yi Ren, Andrew B. Nixon, Jichun Xie, Amy T. Bush, Mark D. Starr, James R. Bain, Michael J. Muehlbauer, Olga Ilkayeva, Virginia Byers Kraus, Janet L. Huebner, Nelson J. Chao, Anthony D. Sung
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Although hematopoietic stem cell transplantation (HCT) is the only curative treatment for acute myeloid leukemia (AML), it is associated with significant treatment related morbidity and mortality. There is great need for predictive biomarkers associa
Externí odkaz:
https://doaj.org/article/b4b09d353c214ef2b6362d7af17d6400
Autor:
Catherine E. Gatza, Jennifer L. Elderbroom, Sun Young Oh, Mark D. Starr, Andrew B. Nixon, Gerard C. Blobe
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 16, Iss 6, Pp 489-500 (2014)
Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily that are over-expressed in breast cancer, with context dependent effects on breast cancer pathogenesis. The type III TGF-β receptor (TβRIII) mediates BMP signaling. While TβR
Externí odkaz:
https://doaj.org/article/56a079dded554a2dac59ffe1f73a942d
Autor:
Yingmiao Liu, Mark D. Starr, Anuradha Bulusu, Herbert Pang, Nan Soon Wong, Wanda Honeycutt, Anthony Amara, Herbert I. Hurwitz, Andrew B. Nixon
Publikováno v:
Cancer Medicine, Vol 2, Iss 2, Pp 234-242 (2013)
Abstract A novel combination of capecitabine, oxaliplatin, and bevacizumab was evaluated in colorectal cancer patients enrolled in a phase II clinical trial. In this retrospective analysis, plasma samples from patients receiving capecitabine, oxalipl
Externí odkaz:
https://doaj.org/article/113c8a5be0e74db0bbb374f15eb404c9
Autor:
Andrew B. Nixon, Herbert I. Hurwitz, Hope E. Uronis, Ivy Altomare, Anthony Amara, Wanda Honeycutt, Herbert Pang, Anuradha Bulusu, Christel Rushing, John C. Brady, Mark D. Starr, Yingmiao Liu
The change from baseline to C2D1 and C3D1 for each biomarker was determined across all patients. Biomarker change was statistically analyzed using Wilcoxon signed rank tests and the corresponding p-values, as well as the direction of change, are pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64a91554a913118e5b92d68e0664dcac
https://doi.org/10.1158/1535-7163.22500114
https://doi.org/10.1158/1535-7163.22500114
Autor:
Andrew B. Nixon, Federico Innocenti, Hanna K. Sanoff, Michael S. Lee, Dominic T. Moore, Anastasia Ivanova, Kouros Owzar, Chiara Cremolini, Alfredo Falcone, Richard M. Goldberg, Daniele Rossini, Federica Marmorino, Kelli Hammond, John C. Brady, Mark D. Starr, Ace J. Hatch, Alexander B. Sibley, Kirsten Bell Burdett, Jing Lyu, Yingmiao Liu
Regorafenib is a tyrosine kinase inhibitor approved by the FDA for the treatment of patients with chemotherapy refractory metastatic colorectal cancer (mCRC). Regorafenib inhibits signaling through multiple receptors associated with angiogenesis, met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc13a6f6766962d7be65cf3e676a3ff
https://doi.org/10.1158/1535-7163.c.6542764
https://doi.org/10.1158/1535-7163.c.6542764
Autor:
Andrew B. Nixon, Herbert I. Hurwitz, Hope E. Uronis, Ivy Altomare, Anthony Amara, Wanda Honeycutt, Herbert Pang, Anuradha Bulusu, Christel Rushing, John C. Brady, Mark D. Starr, Yingmiao Liu
Hierarchical clustering analyses may identify potential patterns of marker expression and biologically relevant groupings. As an example, PDGF-AA and PDGF-BB are tightly clustered at baseline, indicating that if a patient had high PDGF-AA levels, PDG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6696ecf50d6c99a5da1e47d3d1020479
https://doi.org/10.1158/1535-7163.22500117.v1
https://doi.org/10.1158/1535-7163.22500117.v1
Autor:
Andrew B. Nixon, Herbert I. Hurwitz, Hope E. Uronis, Ivy Altomare, Anthony Amara, Wanda Honeycutt, Herbert Pang, Anuradha Bulusu, Christel Rushing, John C. Brady, Mark D. Starr, Yingmiao Liu
A novel combination of bevacizumab and everolimus was evaluated in refractory colorectal cancer patients in a phase II trial. In this retrospective analysis, plasma samples from 49 patients were tested for over 40 biomarkers at baseline and after one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412df4f894599ab824a547151665fd43
https://doi.org/10.1158/1535-7163.c.6536361.v1
https://doi.org/10.1158/1535-7163.c.6536361.v1